Previously submitted to: JMIR Research Protocols (no longer under consideration since Nov 23, 2022)
Date Submitted: Sep 15, 2022
Open Peer Review Period: Sep 13, 2022 - Nov 8, 2022
(closed for review but you can still tweet)
Non-steroidal Anti-Inflammatory Drugs as protective Factor in Alzheimer's Diseases: a Systematic Review and Meta-Analysis Protocol
Background:
NSAIDs inhibit COX-2, which is responsible for regulating neurons leading to neurodegeneration in AD. AD is a neurodegenerative disease affecting the geriatric population, as it affects more than two third cases of dementia in the sphere. Results obtained from experimental and observational studies were unclear regarding the protective role of NSAIDs in AD, therefore this justifies the need for Meta-analysis.
Objective:
1) Role of NSAIDs, as a protective factor for AD in Experimental study design 2) Role of NSAIDs, as a protective factor for AD in Cohort study design 3) Role of NSAIDs, as a protective factor for AD in Case-Control study design
Methods:
Database search was PubMed, WebScience, and Embase. Experimental studies and Observational studies investigating the effect of NSAIDs on AD. For experimental studies indicators used were MMSE score, ADAS-cog score, CDR-sob score, NPI score, and Hazard ratio. Similarly for Observational studies, Odds Ratio and Relative Risk are used.
Results:
As the study is still ongoing, therefore it is not possible to write its results at this stage. There is a total of 06 (MMSE, ADAS-cog, CDR-sob, HR, RR, and OR) indicators used in the ongoing study, so 06 results will be obtained showing the pooled effect size which may indicate the use of NSAIDs as a protective factor for Alzheimer’s disease
Conclusions:
Conclusion can be drawn only after the final meta-analysis using three study design (RCT, Cohort and Case-control study designs) and six indicators.
ClinicalTrial:
PROSPERO [CRD42022301179] prospero (crd42022301179)
Citation
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