Existing Funding Sources in Degenerative Cervical Myelopathy Research: Scoping Review

Background Degenerative cervical myelopathy (DCM) is a common, disabling condition of symptomatic cervical spinal cord compression that requires significant research advances to improve patient outcomes. A James Lind Alliance Partnership recently identified the top research priorities for DCM. To effectively address these priorities, appropriate funding of DCM research is essential. Objective The aim of this paper is to review current funding in DCM research and highlight future research funding opportunities. Methods A systematic search of Web of Science for “cervical AND myelopathy” was conducted. Papers exclusively studying DCM with declared funding and published between January 1, 1995, and March 21, 2020, were considered eligible. Funding sources were classified by country of origin and organization type. A grant search was also conducted using Dimensions.ai (Digital Science Ltd). Results A total of 621 papers were included, with 300 unique funding bodies. The top funders were AO Spine (n=87); National Institutes of Health, USA (n=63); and National Natural Science Foundation, China (n=63). Funding sources in the USA (n=242) supported the most DCM research, followed by China (n=209) and Japan (n=116). Funding in the USA was primarily provided by corporate or nonprofit organizations (146/242, 60.3%), while in China, the majority of funding was from institutions (208/209, 99.5%). Dimensions.ai gives an estimate for the total declared grant funding awards for DCM-specific research. Data here showed 180 grants awarded specifically for DCM research, with a total value of US $45.6 million since 1996. Conclusions DCM funding appears to be predominantly from the USA, China, and Japan, aligning with areas of high DCM research activity and underpinning the importance of funding to increasing research capacity. The existing funding sources differ from medical research in general, representing opportunities for future investment in DCM.


Introduction
Degenerative cervical myelopathy (DCM), often previously referred to as cervical spondylotic myelopathy, is a progressive, slow motion, spinal cord injury caused by degenerative changes that lead to narrowing of the spinal canal [1]. It is the most common nontraumatic cause of spinal cord impairment [2], with recent estimates suggesting that as many as 1 in 50 adults could be affected in their lifetime [3,4].
DCM can cause a range of symptoms, including loss of manual dexterity, imbalance and falls, and incontinence and pain [1]. The mainstay of treatment is decompressive surgery [5]. Although this has been demonstrated to offer the most meaningful benefit, recovery is rarely complete and most people are left with life-long disabilities [1,6]. In a recent comparison of quality of life in chronic disease, people with DCM were found to have one of the lowest 36-Item Short Form Survey (SF-36) scores of any chronic disease [6]. Research leading to improved outcomes is urgently required.
To formally address this problem, a consensus initiative was established to improve research efficiency in DCM. AO Spine Research Objectives and Common Data Elements for DCM (RECODE-DCM) is an international, multistakeholder partnership between surgeons, health care professionals, and patients [7]. A National Institute for Health Research (NIHR) James Lind Alliance priority setting partnership established the top 10 DCM research priorities, including raising awareness, developing new treatments and diagnostic tools, and acquiring a better understanding of pathophysiology [8].
To enable these questions to be addressed, research funding targeting these priorities is urgently needed. The main aim of this study is to characterize the funding of existing DCM research and identify potential future funding organizations. Within this, our objectives are as follows: to characterize which countries, organizations, and type of organizations fund the majority of DCM research and to provide an overview of the estimated total grant funding in DCM.

Methods
To characterize the funding of existing DCM research, we used 2 methods. The first was most closely aligned with a scoping review and involved formulating a research question, identifying relevant studies, and further categorizing and analyzing the results as is standard in a scoping review methodology [9].

Identifying the Research Question
The aim of this study was to characterize the funding of existing DCM research. Although reviews may normally examine the results of individual papers, our search was focused on extracting the funding information of papers and focusing only on whether the article was on DCM.
To estimate the number of funders in DCM research, we attempted to extract funding details from literature databases. Of the existing medical literature databases, the only database allowing extraction of funding details is Web of Science [10,11].

Identifying Relevant Studies
There are many different terms used for DCM around the world [12]. Therefore, to ensure the search was comprehensive, the search terms "cervical AND myelopathy" were used. All papers from January 1, 1995, to March 21, 2020, were eligible for inclusion. These were then filtered by the presence of funder details to exclude entries without explicit funding sources.

Study Selection
The search output was uploaded to Rayyan, a systematic review web platform [13]. Titles and abstracts were then screened independently by 2 authors (JQT and HB). The inclusion criteria for literature were the following: all languages, primary research and systematic or narrative reviews, preclinical and clinical studies, and DCM-related spinal conditions. Meanwhile, the exclusion criteria were the following: corrections, letters, editorials, commentaries, proposals, technical notes, and conference papers; myelopathy not caused by DCM; cervical spinal surgery not specific to DCM; radiculopathy only; and thoracic or lumbar myelopathy. Any conflicts or undecided papers were resolved by discussion between JQT and HB until consensus was reached.

Estimating DCM Grants Using Dimensions.ai
To supplement our study, we undertook an additional search.
Using a grant-searching function on Dimensions.ai (Digital Science Ltd), we gathered funding information from 1996 to the present day using keywords for DCM [14]. Dimensions.ai is a platform that can be used to search grants awarded for specific research. Dimensions.ai provides information on the research title and abstract, investigator, funding amount, and over what period the research is expected to be completed. However, it does not include information regarding whether an author has been supported by a general scholarship and undertaken research in a given area, nor does it give information if a grant awarded for another project coincidentally funded research in another field. It therefore gives an overview of estimated value for total grant funding awards specifically requested for DCM research alone.
The grant information we gathered included the total number of grants on Dimensions.ai, total grant funding, average grant awarded, and date and amount of earliest grant shown on Dimensions.ai.

Charting the Results
Typical paper-specific information that could be recorded in a scoping review (such as aims, methodology, and results) was not necessary to answer our question on the sources of funding for DCM research. As the aim was to examine the funding landscape of DCM research, more information regarding the characteristics of funding organizations was required.

Collating and Summarizing the Results
The total number of papers with a funding body was recorded. These funding bodies were then ordered with regard to how many papers they supported. The funding bodies were further delineated into their country of origin and the type of sector.
Funders were classified by country of origin by 2 authors (JQT and HB). Identifying countries associated with each funder required criteria to classify a funder: the funding body had to be a university, national funding body, provincial or state funding body, or organization or company; the funding body needed to have headquarters in a specific country; and the funding body could not have a country of origin that was unclear.
Some organizations are international without specific association with any particular country and were labeled as such, for example AO Spine. AO Spine is a global organization with headquarters in Switzerland. It is funded by the AO Foundation, with funding distributed globally. It was therefore felt to be best defined as an organization without a specific country of origin. Entries that did not satisfy the criteria were labeled as "unclear." To further investigate funders, we classified them into 2 categories: institutional and corporate/charitable. The corporate/charitable group was further classified into for-profit and not-for-profit organizations.
Funders were classified as institutional if they were any of the following: a regional or central governmental funding body, a university, a research institution, or a hospital associated with a university or research institution.
Alternatively, they were classified as corporate/charitable if they were any of the following: a charitable or not-for profit organization or a for-profit organization or corporation.
The number of institutional organizations compared to corporate/charitable organizations was compared on a global and country level. If the funder did not satisfy either set of criteria or if it was unclear which category they would fit into, they were labeled "unclear."

Study Selection
Of the 6757 papers returned from Web of Science, 621 papers acknowledged funding and survived passed application of our inclusion and exclusion criteria ( Figure 1).
We identified 300 unique funding bodies that supported DCM research (Table 1). Many research papers had more than 1 funding body: there were a total of 920 references of funding from 300 unique funders.

Top Funders for DCM Research
The 300 funding bodies were then ordered according to the number of papers they supported. Table 1 shows this data for the top 10 DCM-specific funding organizations by research output and compares it to the top 10 funding organizations for general health research.

Funded DCM Research by Country
DCM research funding had a global distribution ( Figure 2). The top 3 countries for number of funded DCM papers were the United States, China, and Japan, followed by Canada and the United Kingdom (Table 2 and Table 3). There were 112 papers without a specific country of origin, including 87 funded by AO Spine.   Table 3. Top 10 countries by number of DCM papers that received research funding. The minimum percentage of papers from each country that was supported by research funding is estimated with reference to the total number DCM papers published during this time period from each country [20]. Raw data were requested directly from the author.

Funder Sectors
In total, 598/920 (65%) funding sources were institutional, 318/920 (34.6%) were a corporate/charitable source, and 4/920 (0.4%) were unclear. Of the 318 corporate/charitable sources, 229/318 (72%) were not-for-profit or charitable organizations, and 89/318 (28%) were for-profit corporations. Many funders supported more than 1 paper. The proportion of research funding from institutional and corporate or charitable funders varied across countries (Figure 3). China was the country with the greatest number of papers funded by institutional sources (n=208), followed by Japan (n=96) and the United States (n=96; Table 4). The Unites States was the country with the greatest number of papers funded by corporate or charitable funders (n=146), followed by Japan (n=20) and the United Kingdom (n=14).

Grant Funding Awards
The second part of the results relate to the search on Dimensions.ai. A total of US $45.6 million in grant funding for DCM papers was identified in Dimensions.ai (Table 5).
Different results were obtained using variations of the search terms, including differing numbers of grants and a different percentage of grants that were manually verified to be DCM-specific.

Principal Results
Our study identified 300 unique funding bodies for DCM research. A total of 621 papers acknowledged funding, largely provided by 4 organizations. These, aside from AO Spine, are associated with Japan, China, and the USA. Funding bodies originate from the corporate, charitable, and institutional sectors, but these are distributed unequally across different countries, and research is primarily supported by institutional bodies (598/920, 65%). Our Dimensions.ai research showed a minimum of US $45.6 million dollars of grant funding awards specifically for DCM from 1974 to 2020.

DCM Research Has Relied On a Small Number of Funders
Viergever and Hendriks [21] identified the top 10 funders for health research globally. They identified the US National Institutes of Health (NIH) as the largest funder of all, but many other leading providers were unrepresented in our DCM review, such as the European Commission, UK Medical Research Council, and the Wellcome Trust, the largest philanthropic funding body for health research [21]. Furthermore, only 5 out of 10 countries in our list of the top 10 countries that support DCM research were included in the top 10 of the World Bank's 2018 analysis of research and development research expenditure as a percentage of gross domestic product [22]. These countries include the USA, Japan, South Korea, Germany, and Switzerland. Interestingly, while Israel spent the most on research and development per gross domestic product, our analysis did not identify any funding bodies from Israel. Taken together, this suggests many unused funders and identifies opportunities for DCM research.

Corporate and Charity Sectors Are Underrepresented in DCM
DCM research has relied on institutional organizations, constituting 598 (64.1%) of the listed 920 reported funding sources. Although there are exceptions [11], this contrasts research funding as a whole, which is estimated to be 60% corporate, 30% institutional, and 10% from non-profit organizations [23]. For DCM, the corporate or non-profit sectors remain a challenge. The existing corporate sector for DCM is focused on medical devices and may not be best placed to support the full breadth of research priorities identified by AO Spine RECODE-DCM. For example, DePuy Synthes (a subsidiary of the Johnson & Johnson family of companies) funded 22/621 (3.5%) papers and are solely an orthopedic and neurosurgical device company [24].
Furthermore, while AO Spine has been a notable supporter, DCM does not have a specific funding organization comparable to ones like the Motor Neurone Disease Association or the Multiple Sclerosis Society [25,26]. Charitable organizations are not just significant research funders: they are essential for advocacy. In the United Kingdom for example, the charitable sector contributes £1.6 billion (US $1.7 billion) to medical research [27] and also acts as a lobby group [28]. With Myelopathy.org, DCM now has a dedicated charitable organization, with medical research funding being among its charitable aims [29].
Stakeholders in AO Spine RECODE-DCM have been cognizant of these challenges, which is reflected in the raising of awareness being established as the leading research priority and with understanding the disease burden and socioeconomic impact being among the other priorities.
Begum et al [11], however, demonstrated that burden of disease has been a relatively unimportant driver of research investment or activity. In an analysis of research funding by the US NIH, disease burden correlated poorly with research investment [30]. Instead, funding decisions may be more significantly informed by political influences, public interest, and transmissibility risk [31]. In oncological research, there is a relative paucity of research output for certain cancers, such as lung, esophageal, and pancreatic cancers, despite their increasing burden and poor prognosis [32]. This reinforces the importance of raising awareness for DCM to facilitate funding for research.

Comparison to Prior Work
In a comparison of these results to a study capturing all DCM papers published in the past 25 years [20], our data suggests that at least 27.46% (621/2261) of DCM research has specific funding.
The location of funding aligns with the location of DCM research output, which has been dominated by the USA, China, Japan, and Canada over the past 20 years [33,34]. This was expected and in keeping with other global health care research investment [10]. It highlights the importance of securing investment to accelerate advances in research outcomes. This is, therefore, now a critical part of ensuring that the aims of the AO Spine RECODE-DCM research priorities are met.

The Global Context
We identified a lack of DCM research funding originating in many low-and-middle-income countries (LMICs), including no funding from the entire African continent. This is common to many health care fields [23]. Yusuf et al [35] identified potential causes of lack of neuroscience research in Africa, among which insufficient funding was one. This is notable for 2 reasons. First, DCM is a global problem [1,36]. Spinal cord disorders such as DCM will increase with a globally aging population, and the prevalence and mortality of spinal disorders, particularly the cervical spine, are increasing in LMICs [37]. Second, from a funding perspective, there is increasing investment in health care research and development in LMICs [38]. Notable examples include organizations such as the NIH [39], NIHR [40], and Canadian Institutes of Health Research (CIHR) [41], as well as philanthropic organizations, such as the Bill and Melinda Gates Foundation. Although much funding is targeted for specific priorities or diseases, much is also investigator-led. The driving force and overall aims behind this increased global investment is multifaceted [42][43][44] but nevertheless represents an opportunity for DCM.

Maximizing Investment and Future Directions
Despite relatively little investment, DCM research has made significant progress, with the number of published papers increasing year on year and many conducted without research funding [33]. This has contributed to many advances in DCM research [45]. This also highlights the fact that investment and research activity may not always be a linear relationship. For example, in a review of global research activity within esophageal cancer, it was identified that the USA published relatively little compared to their overall research expenditures, while Japan published relatively more [10].
This calls for reduced system inefficiencies to maximize the return of research investment [46], for example, by ensuring research aligns with community needs [47] and is conducted in a robust and transparent manner [48,49] such that its findings can be effectively used. Addressing inefficiencies is the aim of AO Spine RECODE-DCM [50][51][52][53][54]. In addition to setting research priorities, it has agreed to a standardized definition and name for the condition and for a minimum data set to be measured in all research studies [7,52,53,55].

Limitations
There were some limitations to this review. First, information on the funding of DCM research was extracted from the funding metadata in a single research paper database and the acknowledgement sections of published articles therein. Lack of funding information in other common databases prohibited their use. Nonetheless, a database of research funding grants was searched in parallel and the data considered together [56,57]. Although this approach was innovative, systematic, and able to identify a significant amount of data, it is unlikely to have been comprehensive, thus representing a minimum estimate of funding. Research on funding is a largely unexplored area, and the systems in place to document funding sources and tools to support interrogating these systems remain limited and inconsistent.
Second, the funding of published research papers is only a surrogate for research investment [58,59]: it does not quantify the specific amount or role of funding, nor does it account for unpublished research. Moreover, the discrepancies we identified in the results of similar search terms in Dimensions.ai highlights the inconsistency in terminology in this field. However, using papers gives the general overview that our study aims to provide and is a useful and pragmatic way to understand how research is broadly supported.
Third, we categorized funders into institutional, corporate, or charitable groups. However, this may be too simplistic. In reality, organizations are complex and interconnected, with institutions receiving charitable funding [60] and charities receiving corporate backing [28]. Despite this, our study does give a broad understanding over how DCM research is supported by these sectors.
Finally, we note that our review contained studies mainly in English, 1 in German, but none in Chinese. The contribution of Chinese-language papers to global research is significant; Xie and Freeman [61] attribute 37% of global citations in scientific articles to China, compared to our 34% of papers with a Chinese funding origin.
Chinese language papers were not explicitly excluded by our review, but none were identified in the results. We note that Web of Science, our required platform due to its unique ability to extract funding information, searches a relatively small population of Chinese-language papers [61]. There may be a population of DCM papers with a funder originating in China and written in Chinese which has not been included in this study. Although we might have underestimated the total contribution of Chinese funding to DCM research, we still show a substantial contribution. Thus, our study provides as useful, pragmatic, and comprehensive snapshot as is currently feasible.

Conclusions
This is the first review to attempt a global synthesis of the funding landscape of global DCM research, which highlights opportunities for future DCM research. AO Spine has been the leading funder of DCM research, while on a country-specific basis, DCM research has predominantly been funded by the USA, China, and Japan. As this aligns with areas of high research output, it reaffirms the importance of research investment for accelerating advances in DCM. The paucity of investment from major funding organizations and countries with leading research and development expenditure, alongside the increasing investment in global health research, represents opportunities for DCM.

Surgeons Research Fellowship and an NIHR Clinical Doctoral Research Fellowship. OM is supported by an Academic Clinical
Fellowship. AO Spine RECODE-DCM study was organized and funded by AO Spine through the AO Spine Knowledge Forum Spinal Cord Injury, a focused group of international spinal cord injury experts. AO Spine is a clinical division of the AO Foundation, which is an independent medically guided not-for-profit organization. Study support was provided directly through the AO Spine Research Department.

Data Availability
This article uses data available on Web of Science and Dimensions.ai.

Disclaimer
This report is independent research arising from a Clinician Scientist Award (#CS-2015-15-023) and a Clinical Doctoral Research Fellowship supported by the NIHR. The views expressed in this publication are those of the authors and not necessarily those of the NHS, the NHIR, or the Department of Health and Social Care.