Login Register Cart 0
Generic placeholder image

Current Traditional Medicine

Editor-in-Chief

ISSN (Print): 2215-0838
ISSN (Online): 2215-0846

Back
Journal Home About Journal Editorial Board Journal Insight Current Issue Volumes/Issues
Subscribe
Review Article

A Concise Review on Therapeutic Potential, Phytochemistry and Traditional Applications of Safed Musli (Chlorophytum borivilianum)

Author(s): Prashant K. Dhakad, Raghav Mishra*, Isha Mishra and Vikram Sharma

Volume 10, Issue 4, 2024

Published on: 21 August, 2023

Article ID: e090823219567 Pages: 11

DOI: 10.2174/2215083810666230809103444

Price: $65

Abstract

Background: In traditional medicine, Safed musli is a very popular herb. Natural sex tonics like Chlorophytum borivilianum (C. borivilianum) are effective in alleviating sexual disorders. Local healers in indigenous communities of India mostly use it for ethnic medicine. The circulation of blood is one of the functions it improves to enhance strength and energy. Since ancient times, the tuber roots of the plant Safed musli have been used to treat weakness and male impotency.

Objective: The aim of this work is to bridge the scientific evidence with the pharmacological, phytochemical, and folkloric claims reported in different sources belonging to C. borivilianum.

Methods: To build the manuscript, a detailed literature review was carried out by thoroughly analyzing globally accepted scientific research databases.

Results: Safed musli is widely recognized for its efficacy in addressing male impotence. The abundant presence of phytoconstituents, particularly saponins, contributes to the nutritional and multifaceted therapeutic significance of C. borivilianum.

Conclusion: The current review enlightens the pharmacotherapeutic potential of C. borivilianum, comprising its origin and distribution, botany, proximate composition, method of enhancing seed germination, pathology, phytochemistry, pharmacology, and traditional uses. The scope for future research is provided by the present review, which also furnishes a gateway for filling the existing gap in its various aspects of investigation.

Keywords: Safed musli, Chlorophytum, phytoconstituent, pharmacology, therapeutic, traditional.

Graphical Abstract

[1]
Mishra I, Sachan N. Thiazole scaffold: An overview on its synthetic and pharmaceutical aspects. ECS Trans 2022; 107(1): 17745-68.
[http://dx.doi.org/10.1149/10701.17745ecst]
[2]
Mishra R, Tomer I, Kumar S. Synthesis and antimicrobial evaluation of novel thiophene derivatives. Pharm Sin 2012; 3: 332-6.
[3]
Upadhyay PK, Pathak S, Mishra R, Kumar R, Jain A. A multifaceted scaffold for building bioactive compounds: Phenothiazine. Lett Org Chem 2023; 20(7): 618-31.
[http://dx.doi.org/10.2174/1570178620666221202100529]
[4]
Mishra R, da Cunha Xavier J, dos Santos HS, et al. Chalcones as potent agents against Staphylococcus aureus: A computational approach. Lett Drug Des Discov 2023; 20.
[http://dx.doi.org/10.2174/1570180820666230120145921]
[5]
Mishra I. Preferences of Indian women on COVID-19 medical solutions. Biosci Biotechnol Res Commun 2021; 14(3): 1381-4.
[http://dx.doi.org/10.21786/bbrc/14.3.71]
[6]
Mishra R, Chaudhary K, Mishra I. Weapons and strategies against COVID-19: A perspective. Curr Pharm Biotechnol 2023; 24.
[http://dx.doi.org/10.2174/1389201024666230525161432] [PMID: 37231727]
[7]
Mishra R, Chaudhary K, Mishra I. AI in health science: A perspective. Curr Pharm Biotechnol 2023; 24(9): 1149-63.
[http://dx.doi.org/10.2174/1389201023666220929145220] [PMID: 36177622]
[8]
Mishra R, Kumar N, Sachan N. Synthesis, biological evaluation, and docking analysis of novel tetrahydrobenzothiophene derivatives. Lett Drug Des Discov 2022; 19(6): 530-40.
[http://dx.doi.org/10.2174/1570180819666220117123958]
[9]
Mishra R, Kumar N, Sachan N. Synthesis, pharmacological evaluation, and in-silico studies of thiophene derivatives. Oncologie 2021; 23(4): 493-514.
[http://dx.doi.org/10.32604/oncologie.2021.018532]
[10]
Mishra R, Kumar N, Mishra I, Sachan N. A review on anticancer activities of thiophene and its analogs. Mini Rev Med Chem 2020; 20(19): 1944-65.
[http://dx.doi.org/10.2174/1389557520666200715104555] [PMID: 32669077]
[11]
Thakur G, Bag M, Sanodiya B, et al. Chlorophytum borivilianum: A white gold for biopharmaceuticals and neutraceuticals. Curr Pharm Biotechnol 2009; 10(7): 650-66.
[http://dx.doi.org/10.2174/138920109789542084] [PMID: 19751181]
[12]
Deshwal RK, Trivedi P. Effect of kinetin on enhancement of tuberous root production of Chlorophytum borivilianum. Int J Innov Biol Chem Sci 2011; 1: 28-31.
[13]
Jagtap SD, Deokule SS, Pawar PK, Harsulkar AM. Traditional ethnomedicinal knowledge confined to the Pawra tribe of Satpura Hills, Maharashtra, India. Ethnobot Leaflets 2009; 2009(1): 12.
[14]
Meena AK, Rao MM. Folk herbal medicines used by the Meena community in Rajasthan. Asian J Tradit Med 2010; 5(1): 19-31.
[15]
Murti Y, Agrawal KK, Semwal BC, Gupta J, Gupta R. A review on novel herbal drug delivery system and its application. Curr Tradit Med 2023; 9(2): e280422204154.
[http://dx.doi.org/10.2174/2215083808666220428092638]
[16]
Murti Y, Agrawal KK. Tangeretin: A biologically potential citrus flavone. Curr Tradit Med 2022; 8(4): e040322201698.
[http://dx.doi.org/10.2174/2215083808666220304100702]
[17]
Ahuja A, Singh S. Impact of the current scenario and future perspectives for the management of oral diseases: Remarkable contribution of herbs in dentistry. Antiinfect Agents 2022; 20(5): e050422203119.
[http://dx.doi.org/10.2174/2211352520666220405124929]
[18]
Singh S, Bajpai M, Mishra P. Herbal folklore medication for liver disorders. Curr Tradit Med 2021; 7(3): 415-33.
[http://dx.doi.org/10.2174/2215083806999201112093503]
[19]
Patel K, Mishra R, Patel DK. A review on phytopharmaceutical importance of asiaticoside. J Coast Life Med 2016; 4(12): 1000-7.
[http://dx.doi.org/10.12980/jclm.4.2016J6-161]
[20]
Dhakad PK, Sharma PK, Kumar S, Kumar N, Dudhe R, Mishra R. Therapeutic role of phytoconstituents in treatment of cerebral ischemia/reperfusion injury. J Pharmacogn Phytochem 2016; 5(2): 187-94.
[21]
Giribabu N, Kumar KE, Rekha SS, Muniandy S, Salleh N. Chlorophytum borivilianum (Safed Musli) root extract prevents impairment in characteristics and elevation of oxidative stress in sperm of streptozotocin-induced adult male diabetic Wistar rats. BMC Complement Altern Med 2014; 14(1): 291.
[http://dx.doi.org/10.1186/1472-6882-14-291] [PMID: 25104050]
[22]
Patil DA. Ethnography of the drug safed: Musali in India: A review. Anc Sci Life 2001; 21(1): 51-65.
[PMID: 22557034]
[23]
Rai PK, Lalramnghinglova H. Ethnomedicinal plants of india with special reference to an indo-burma hotspot region: An overview. Ethnobot Res Appl 2011; 9: 379.
[http://dx.doi.org/10.17348/era.9.0.379-420]
[24]
Shrivastava M, Sharma P, Singh R. Microbial quality assurance of dried roots of Chlorophytum borivilianum sant F (Safed Musli). European J Med Plants 2021; 1-11.
[http://dx.doi.org/10.9734/ejmp/2021/v32i930413]
[25]
Poulsen AD, Nordal I. A phenetic analysis and revision of Guineo-Congolean rain forest taxa of Chlorophytum (Anthericaceae). Bot J Linn Soc 2005; 148(1): 1-20.
[http://dx.doi.org/10.1111/j.1095-8339.2005.00386.x]
[26]
Sisodia R. GC-MS and HPLC analysis of Chlorophytum borivilianum (safed musli) a plant from ayurveda-herbal viagra. Glob J Reprod Med 2020; 7(5): 5556723.
[http://dx.doi.org/10.19080/GJORM.2020.07.555723]
[27]
Nikam VK, Chavan PD. Chlorophytum borivilianum (Safed musli): A Review. Phcog Rev 2009; 3(5): 154-69.
[28]
Chakraborthy GS, Aeri V. Phytochemical and antimicrobial studies of Chlorophytum borivilianum. Int J Pharm Sci Drug Res 2009; 1: 110-2.
[29]
Raghavendra VB, Lokesh S, Kumar TV, Shetty HS. Compatibility of phyton with common fungicide and their role on the yield of safed musli. World J Agric Res 2005; 1(1): 62-4.
[30]
Bhat MH, Fayaz M, Kumar A, Jain AK. Phytochemical, pharmacological and nutritional profile of chlorophytum tuberosum (roxb.) baker (Safed musli): A Review. Int J Theor Appl Sci 2018; 10(1): 93-9.
[31]
Arora DK, Jain AK, Ramawat KG, Merillon JM. Chlorophytum borivilianum: An Endangered Aphrodisiac HerbBiotech Med Pla. CRC Press 2004; pp. 125-42.
[32]
Begum N, Ved DK. Botanical bases of the curative commodities. Amruth: Botanical roots of raw drugs; The Traditional Health Care. Bangalore: The MedPlan Cons Soc 2003; pp. 3-8.
[33]
Ram D, Saini PK. Effect of varieties and spacing on vegetative growth and root yield of safed musli (Chlorophytum borivilianum). Int J Plant Soil Sci 2022; 1728-36.
[http://dx.doi.org/10.9734/ijpss/2022/v34i2231553]
[34]
Maiti S, Geetha KA. Characterization, genetic improvement and cultivation of Chlorophytum borivilianum-An important medicinal plant of India. Plant Genet Resour 2005; 3(2): 264-72.
[http://dx.doi.org/10.1079/PGR200579]
[35]
Khanam Z, Singh O, Singh R, Bhat IUH. Safed musli (Chlorophytum borivilianum): A review of its botany, ethnopharmacology and phytochemistry. J Ethnopharmacol 2013; 150(2): 421-41.
[http://dx.doi.org/10.1016/j.jep.2013.08.064] [PMID: 24045177]
[36]
Roy A, Pradhan P. Access and benefit sharing scope of indian medicinal plants Biodiversity Conservation Through Access and Benefit Sharing (ABS). Cham: Springer International Publishing 2022; pp. 327-59.
[http://dx.doi.org/10.1007/978-3-031-16186-5_17]
[37]
Younas A, Riaz N, Rashid M. Multi-omics approaches for breeding in medicinal plants Sustainable Agriculture in the Era of the OMICs Revolution. Cham: Springer International Publishing 2023; pp. 165-91.
[http://dx.doi.org/10.1007/978-3-031-15568-0_8]
[38]
Nikazar S, Pezeshkpour S, Bahrololoumi S. Plant polysaccharides as suspending agents in pharmaceutical suspensions Plant Polysaccharides as Pharmaceutical Excipients. Elsevier 2023; pp. 103-24.
[http://dx.doi.org/10.1016/B978-0-323-90780-4.00016-4]
[39]
Kaur R, Arora S, Thukral AK. Enhancing Seed Germination of Chlorophytyum borivilianum Sant. Et Fernand. with PGRs, Steroidal Hormones and Zinc. Res J Seed Sci 2009; 2(2): 32-9.
[http://dx.doi.org/10.3923/rjss.2009.32.39]
[40]
Husen A. Herbs, Shrubs, and Trees of Potential Medicinal Benefits. London, England: 1st ed.; Taylor & Francis 2022; p. 472.
[http://dx.doi.org/10.1201/9781003205067]
[41]
Murashige T, Skoog F. A revised medium for rapid growth and bio assays with tobacco tissue cultures. Physiol Plant 1962; 15(3): 473-97.
[http://dx.doi.org/10.1111/j.1399-3054.1962.tb08052.x]
[42]
Purohit SD, Dave A, Kukda G. Micropropagation of safed musli (Chlorophytum borivilianum), a rare Indian medicinal herb. Plant Cell Tissue Organ Cult 1994; 39(1): 93-6.
[http://dx.doi.org/10.1007/BF00037596]
[43]
Joshi A, Ganesh R, Sharma A, Sharma GS. Plant regeneration from stem-disc derived callus cultures of Chlorophytum borivilianum. Annu Rev Plant Biol 1999; 13: 79-83.
[44]
Singh R, Sharma R, Mal G, Varshney R. A comparative analysis of saponin-enriched fraction from Silene vulgaris (Moench) Garcke, Sapindus mukorossi (Gaertn) and Chlorophytum borivilianum (Santapau and Fernandes): an in vitro hemolytic and cytotoxicity evaluation. Anim Biotechnol 2022; 33(1): 193-9.
[http://dx.doi.org/10.1080/10495398.2020.1775627] [PMID: 35105278]
[45]
Singh A, Khanuja SPS, Singh S. Agronomic practices for the production of safed musli (Chlorophytum borivilianum Santapau and Fernandes). Nat Prod Radiance 2003; 2: 308-13.
[46]
Goyal RK. Satavar and safed musli-ingredients for herbal food: An appraisal. J Nutrit HealFood Eng 2018; 8(3): 253-8.
[http://dx.doi.org/10.15406/jnhfe.2018.08.00279]
[47]
Dubey A, Bhushan D, Kawatra N. Phytochemical analysis of nardostachys jatamansi dc, Chlorophytum borivilianum (soil based) and Chlorophytum borivilianum (commercial). diet 2022; 11(1): 42-6.
[http://dx.doi.org/10.32692/IJDI-ERET/11.1.2022.2207]
[48]
Niranjan A, Tewari SK, Das B. Phytochemical and antioxidant potential of Chlorophytum borivilianum (Safed musli) under different agronomical management practices. Int J Appl Agric Res 2009; 4(1): 47-55.
[49]
Vyas R, Kesari KK, Slama P, Roychoudhury S, Sisodia R. Differential activity of antioxidants in testicular tissues following administration of Chlorophytum borivilianum in gamma-irradiated swiss albino mice. Front Pharmacol 2022; 12: 774444.
[http://dx.doi.org/10.3389/fphar.2021.774444] [PMID: 35111049]
[50]
Trivedi M, Tiwari RK. Method of enhancing seed germination in Chlorophytum sp. Int J Eng Res Technol 2016; 3(5): 21-5.
[51]
Jaiswal D, Pandey A, Agrawal M, Agrawal SB. Photosynthetic, biochemical and secondary metabolite changes in a medicinal plant chlorophytum borivillianum (safed musli) against low and high doses of UV‐B radiation. Photochem Photobiol 2023; 99(1): 45-56.
[http://dx.doi.org/10.1111/php.13672] [PMID: 35837836]
[52]
Raghavendra VB, Lokesh S, Kumar V. Disease notes or new records: First report of tuber rot of Safed musli (Chlorophytum borivilianum) caused by Fusarium solani in India. Aust J Plant Physiol 2005; 34: 275-6.
[53]
Ahir RR, Tak SK, Singh N, Verma OP. Two new diseases of medicinal plants caused by Fusarium solani. J Mycol Plant Pathol 2006; 36(1): 18-9.
[54]
Singh HB, Singh A, Tripathi A, Tiwari SK, Johri JK. Collar rot of Chlorophytum borivilianum caused by Corticium rolfsii: A new disease. Bull OEPP 2001; 31(1): 112-3.
[http://dx.doi.org/10.1111/j.1365-2338.2001.tb00977.x]
[55]
Pandey R. Root-knot disease of safed musli. Indian J Nemat 2003; 33(1): 64.
[56]
Sattar A, Alam M, Khaliq A, Shukla RS, Khanuja SPS. First report of leaf blight of Chlorophytum borivilianum caused by Colletotrichum capsici in northern India. Plant Pathol 2006; 55(2): 301.
[http://dx.doi.org/10.1111/j.1365-3059.2005.01296.x]
[57]
Mandal K, Maiti S, Saxene DR, Saxena M. A new leaf spot disease of Safed musli. J Mycol Plant Pathol 2004; 34(1): 162-3.
[58]
Oudhia P. Record of orange banded blister beetle, Zonabris pustulata Thunb. (Mylabris pustulata) (Coleoptera: Meloidae) on safed musli (Chlorophytum borivilianum). Insect Environ 2000; 6: 138.
[59]
Phurailatpam K, Geetha KA, Gajbhiye NA, Saravanan R, Maiti S. Comparative study of Chlorophytum borivilianum sant. & fernand. and chlorophytum arundinaceum baker-two ‘safed musli’ species used as vital tonics in Indian system of medicine. Phytomorphology 2009; 59(1): 77.
[60]
Mathew PM, Thomas KJ. Cytological studies on Chlorophytum. New Bot 1974; 1: 34-45.
[61]
Baldwin JT Jr, Speese BM. Cytogeography of Chlorophytum in Liberia. Am J Bot 1951; 38(2): 153-6.
[http://dx.doi.org/10.1002/j.1537-2197.1951.tb14807.x]
[62]
Kanchan SD, Geeta KS. Parthenin-A pretreatment reagent for chromosomes. Curr Sci 1977; 46: 354-5.
[63]
Boraiah G. Cytology of Chlorophytum attenuatum Baker and Chlorophytum undulatum Wall. Mysore J Agric Sci 1967; 1: 294-5.
[64]
Thomas KJ. Cytogenetic investigations on the genus C. II. Reciprocal translocation in somatic chromosomes of C. heynei Baker (Chlorophytum heyneanum Wall.). Cytologia 1960; 25: 97-100.
[http://dx.doi.org/10.1508/cytologia.25.97]
[65]
Sarkar AK, Datta N, Chatterjee U. Confirmation on a basic number for the genus Launaea Cass. Sci Cult 1973; 39: 95-6.
[66]
Naik VN. Erroneous report of the basic chromosome number in Chlorophytum. Sci Cult 1977; 43: 260-1.
[67]
Tiwari PN. Effect of fertility levels on yield and quality of safed musli (Chlorophytum borivilianum). Crop Res 2006; 32(3): 554-5.
[68]
Wagle A, Kelkar GD, Heble MR. Biotechnology: Secondary Metabolites. Oxford and IBH Publishing Co.Pvt. Ltd. 2000; pp. 219-20.
[69]
Dev M, Rawat S, Kumar S. Status and population diversity of plant-parasitic nematodes in medicinal plants of uttarakhand. Indian J Nematol; Off Publ Nematological Soc 2022; 52(2): 276-86.
[http://dx.doi.org/10.5958/0974-4444.2022.00032.4]
[70]
Narasimhan S, Govindarajan R, Madhavan V, et al. Action of (2-->1)Fructo-oligopolysaccharide fraction of Chlorophytum borivilianum against Streptozotocin-induced oxidative stress. Planta Med 2006; 72(15): 1421-4.
[http://dx.doi.org/10.1055/s-2006-951705] [PMID: 17051465]
[71]
Kothari SK, Reddy PS. Response of safed musli (Chlorophytum borivilianum Santapau and Fernandes) to methods of planting, spacing, harvesting age and cropping system. Curr Res Med Aromat Plants 2009; 31(4): 302-7.
[72]
Devon TK, Scott AI. Handbook of Naturally Occurring Compounds: Terpenes. San Diego, CA: Academic Press 1972; Vol. 2.
[73]
Thakur M, Dixit VK. Fructan: The polymer with unexplored potential. Ind Pharm 2005; 4(40): 7-12.
[74]
Tandon M, Shukla YN. Sapogenins from Asparagus adscendens and Chlorophytum arundinaceum. J Indian Chem Soc 1999; 69: 893.
[75]
Li XC, Wang DZ, Yang CR. Steroidal saponins from Chlorophytum malayense. Phytochemistry 1990; 29(12): 3893-8.
[http://dx.doi.org/10.1016/0031-9422(90)85354-I]
[76]
Kaushik N. Saponins of Chlorophytum Species. Phytochem Rev 2005; 4(2-3): 191-6.
[http://dx.doi.org/10.1007/s11101-005-2607-5]
[77]
Kumar A, Nandi SK, Chandra B, Pal M. Conservation of some himalayan medicinal plants using biotechnological approaches. Indian For 2004; 130: 187-99.
[78]
Tandon M, Shukla YN. Arundinoside B, a new acylated glucoside from Chlorophytum arundinaceum. J Indian Chem Soc 1996; 35: 988-9.
[79]
Tandon M, Shukla YN. Arundinoside A- a new spirostane from Chlorophytum arundinaceum. J Indian Chem Soc 1997; 74: 56-8.
[80]
Shi A, Ganesh R, Sharma A, Audichya P. Sapogenine content determination in Chlorophytum borivilianum L. BioNature 2000; 20: 47-9.
[81]
Fukuda N, Tanaka H, Shoyama Y. Isolation of the pharmacologically active saponin ginsenoside Rb1 from ginseng by immunoaffinity column chromatography. J Nat Prod 2000; 63(2): 283-5.
[http://dx.doi.org/10.1021/np990356s] [PMID: 10691730]
[82]
Acharya D, Mitaine-Offer AC, Kaushik N, Miyamoto T, Lacaille-Dubois MA. Furostanol glycosides from the roots of Chlorophytum borivilianum. Planta Med 2007; 73(9)
[http://dx.doi.org/10.1055/s-2007-987210]
[83]
Estrada A, Katselis GS, Laarveld B, Barl B. Isolation and evaluation of immunological adjuvant activities of saponins from Polygala senega L. Comp Immunol Microbiol Infect Dis 2000; 23(1): 27-43.
[http://dx.doi.org/10.1016/S0147-9571(99)00020-X] [PMID: 10660256]
[84]
Sparg SG, Light ME, van Staden J. Biological activities and distribution of plant saponins. J Ethnopharmacol 2004; 94(2-3): 219-43.
[http://dx.doi.org/10.1016/j.jep.2004.05.016] [PMID: 15325725]
[85]
Bruneton J. Pharmacognosy Phytochemistry. Medicinal Plants. New York, NY: Springer 1995.
[86]
Kumar KA, Chitra V, Leela Krishna V, Soujanya J. Evaluation of immunomodulatory effect of hydroalcoholic root extract of Chlorophytum arundinaeceum Baker in mice. Int J Pharm Pharm Sci 2011; 3: 355-9.
[87]
Patel DK, Kumar R, Prasad SK, Hemalatha S. Pharmacologically screened aphrodisiac plant-A review of current scientific literature. Asian Pac J Trop Biomed 2011; 1(1): S131-8.
[http://dx.doi.org/10.1016/S2221-1691(11)60140-8]
[88]
Deore SL, Baviskar BA, Rangari AS. Rapid and high yield extraction method for saponins from safed musli. Pharmacogn J 2015; 7(4): 210-4.
[http://dx.doi.org/10.5530/pj.2015.4.1]
[89]
Sharma OP, Kumar N, Singh B, Bhat TK. An improved method for thin layer chromatographic analysis of saponins. Food Chem 2012; 132(1): 671-4.
[http://dx.doi.org/10.1016/j.foodchem.2011.10.069] [PMID: 26434348]
[90]
Barve KH, Laddha KS, Jayakumar B. Extraction of saponins from safed musli. Pharmacogn J 2010; 2(13): 561-4.
[http://dx.doi.org/10.1016/S0975-3575(10)80060-4]
[91]
Thakur M, Dixit VK. Effect of Chlorophytum borivilianum on androgenic & sexual behavior of male rats. Indian Drugs 2006; 43: 300-6.
[92]
Panda SK, Si SC, Bhatnagar SP. Studies on hypoglycaemic and analgesic activities of Chlorophytum borivilianum Sant and Ferz. J Nat Rem 2007; 7: 31-6.
[93]
Visavadiya NP, Narasimhacharya AVRL. Ameliorative effect of Chlorophytum borivilianum root on lipid metabolism in hyperlipaemic rats. Clin Exp Pharmacol Physiol 2007; 34(3): 244-9.
[http://dx.doi.org/10.1111/j.1440-1681.2007.04579.x] [PMID: 17250646]
[94]
Kenjale RD, Shah RK, Sathaye SS. Anti-stress and anti-oxidant effects of roots of Chlorophytum borivilianum (Santa Pau & Fernandes). Indian J Exp Biol 2007; 45(11): 974-9.
[PMID: 18072542]
[95]
Thakur M, Bhargava S, Dixit VK. Immunomodulatory activity of Chlorophytum borivilianum Sant. F. Evid Based Complement Alternat Med 2007; 4(4): 419-23.
[http://dx.doi.org/10.1093/ecam/nel094] [PMID: 18227908]
[96]
Deore SL, Khadabadi SS. Antiinflammatory and antioxidant activity of Chlorophytum borivilianum root extracts. Asian J Chem 2008; 20: 983-6.
[97]
Kenjale R, Shah R, Sathaye S. Effects ofChlorophytum borivilianum on sexual behaviour and sperm count in male rats. Phytother Res 2008; 22(6): 796-801.
[http://dx.doi.org/10.1002/ptr.2369] [PMID: 18412148]
[98]
Thakur M, Loeppert R, Praznik W, Dixit V. Effect of Some Ayurvedic Vajikaran Rasayana Herbs on Heat Induced Testicular Damage in Male Albino Rats. J Complement Integr Med 2008; 5(1)
[http://dx.doi.org/10.2202/1553-3840.1112]
[99]
Deore SL, Khadabadi SS. Screening of antistress properties of Chlorophytum borivilianum tuber. Pharmacologyonline 2009; 1: 320-8.
[100]
Thakur M, Bhargava S, Praznik W, Loeppert R, Dixit VK. Effect of Chlorophytum borivilianum Santapau and Fernandes on sexual dysfunction in hyperglycemic male rats. Chin J Integr Med 2009; 15(6): 448-53.
[http://dx.doi.org/10.1007/s11655-009-0448-6] [PMID: 20082251]
[101]
Mujeeb M, Khan SA, Ali M, Mall A, Ahmad A. Antidiabetic activity of the aqueous extract of Chlorophytum borivilianum L. in streptozotocin induced-hyperglycemic rats: A preliminary study. J Pharm Res 2009; 2: 5-53.
[102]
Kumar M, Meena P, Verma S, Kumar M, Kumar A. Anti-tumour, anti-mutagenic and chemomodulatory potential of Chlorophytum borivilianum. Asian Pac J Cancer Prev 2010; 11(2): 327-34.
[PMID: 20843110]
[103]
Deore SL, Khadabadi SS. Effect of Chlorophytum borivilianum on adjuvant induced arthritis in rats. Ann Biol Res 2010; 1: 36-40.
[104]
Thakur M, Connellan P, Deseo MA, Morris C, Dixit VK. Immunomodulatory polysaccharide from Chlorophytum borivilianum roots. Evid Based Complement Alternat Med 2011; 2011: 1-7.
[http://dx.doi.org/10.1093/ecam/neq012] [PMID: 21792363]
[105]
Panda SK, Das D, Tripathy NK. Studies on anti-ulcer activity of root tubers of Chlorophytum borivilianum Santapau and Fernandes. Int J Pharm Sci Rev Res 2011; 9: 65-8.
[106]
Thakur M, Thompson D, Connellan P, Deseo MA, Morris C, Dixit VK. Improvement of penile erection, sperm count and seminal fructose levels in vivo and nitric oxide release in vitro by ayurvedic herbs. Andrologia 2011; 43(4): 273-7.
[http://dx.doi.org/10.1111/j.1439-0272.2010.01068.x] [PMID: 21486409]
[107]
Visavadiya NP, Narasimhacharya AVRL. Ameliorative effects of herbal combinations in hyperlipidemia. Oxid Med Cell Longev 2011; 2011: 1-8.
[http://dx.doi.org/10.1155/2011/160408] [PMID: 21941605]
[108]
Panda SK, Das D, Tripathy NK. Anti-inflammatory potential of Chlorophytum borivilianum Sant and Fern. root tubers. J Glob Trends Pharm Sci 2011; 2: 242-51.
[109]
Panda SK, Das D, Tripathy NK. A study on antipyretic activity of Chlorophytum borivilianum Sant. and Fern. root tubers. Int J Pharm Res Dev 2011; 3: 153-6.
[110]
Sharma SK, Kumar M. Hepatoprotective effect of Chlorophytum borivilianum root extract against arsenic intoxication. Pharmacologyonline 2011; 3: 1021-32.
[111]
Mahajan GK, Mahajan AY, Mahajan RT. Efficacy of aphrodisiac plants towards improvement in semen quality and motility in infertile males. J Complement Integr Med 2012; 9(1): 1-12.
[http://dx.doi.org/10.1515/1553-3840.1520] [PMID: 22499723]
[112]
McCarthy CG, Alleman RJ, Bell ZW, Bloomer RJ. A dietary supplement containing Chlorophytum borivilianum and velvet bean improves sleep quality in men and women. Integr Med Insights 2012; 7: IMI.S9720.
[http://dx.doi.org/10.4137/IMI.S9720] [PMID: 22778558]
[113]
Sharma G, Kumar M. Antioxidant and modulatory role of Chlorophytum borivilianum against arsenic induced testicular impairment. J Environ Sci 2012; 24(12): 2159-65.
[http://dx.doi.org/10.1016/S1001-0742(11)61019-X] [PMID: 23534213]
[114]
Govindarajan R, Sreevidya N, Vijayakumar M. In vitro antioxidant activity of ethanolic extract of Chlorophytum borivilianum. Nat Prod Sci 2005; 11: 165-9.
[115]
Dabur R, Gupta A, Mandal TK, et al. Antimicrobial activity of some Indian medicinal plants. Afr J Tradit Complement Altern Med 2008; 4(3): 313-8.
[http://dx.doi.org/10.4314/ajtcam.v4i3.31225] [PMID: 20161895]
[116]
Deore SL, Khadabadi SS. In vitro antimicrobial studies of Chlorophytum borivilianum (liliaceae) root extracts. Asian J Microbiol Biotechnol Environ Sci 2007; 9: 807-9.
[117]
Chakraborthy GS. Antioxidant activity of the successive extracts of Chlorophytum borivilianum leaves. Asian J Chem 2008; 20: 5782-4.
[118]
Chakraborthy GS. Antimicrobial activity of Chlorophytum borivilianum leaves. Indian Drugs 2009; 46: 61-3.
[119]
Deore SL, Khadabadi SS. Larvicidal activity of the saponin fractions of Chlorophytum borivilianum santapau and Fernandes. J Entomol Nematol 2009; 1: 64-6.
[120]
Visavadiya NP, Soni B, Dalwadi N, Madamwar D. Chlorophytum borivilianum as potential terminator of free radicals in various in vitro oxidation systems. Drug Chem Toxicol 2010; 33(2): 173-82.
[http://dx.doi.org/10.3109/01480540903311068] [PMID: 20307144]
[121]
Panda SK, Das D, Tripathy NK. Evaluation of anthelmintic activity of Chlorophytum borivilianum Santapau and Fernandes. Int J Pharm Biomed Res 2011; 2: 676-9.
[122]
Sundaram S, Dwivedi P, Purwar S. Antibacterial activities of crude extracts of Chlorophytum borivilianum to bacterial pathogens. Res J Med Plant 2011; 5(3): 343-7.
[http://dx.doi.org/10.3923/rjmp.2011.343.347]
[123]
Sriram S, Meena V, Kavitha Srilakshmi J. Evaluation of antibacterial activity of Chlorophytum borivilianum against selected pathogens. J Res Antimicrob 2012; 1: 028-31.
[124]
Roselin P, Raj MS. In vitro testing of the antibacterial activity of root extracts of Chlorophytum borivilianum against organisms causing postnatal infections. RRJoHS 2012; 1: 24-31.
[125]
Goswami SK, Manoj Kumar P, Jamwal R, Dethe S, Agarwal A, Mohammed Naseeruddin I. Screening for Rho-kinase 2 inhibitory potential of Indian medicinal plants used in management of erectile dysfunction. J Ethnopharmacol 2012; 144(3): 483-9.
[http://dx.doi.org/10.1016/j.jep.2012.07.045] [PMID: 23043981]
[126]
Pawankumar G, Shiradkar M. Evaluation of synergistic effect of Chlorophytum borivilianum extract on transdermal delivery of Pramipexole with its mechanism of action. Adv Appl Sci Res 2012; 3: 261-7.
[127]
Khatri P, Rana JS, Sindhu A, Jamdagni P. Effect of additives on enhanced in-vitro shoot multiplication and their functional group identification of Chlorophytum borivilianum Sant. Et Fernand. SN Appl Sci 2019; 1(9): 1105.
[http://dx.doi.org/10.1007/s42452-019-1118-8]
[128]
Nandal R. Formulation development and characterization of ointments containing Bambusa arundinacea extract and Chlorophytum borivilianum extract. Int J Med Pharma Sci 2022; 12(10): 01-5.
[http://dx.doi.org/10.31782/IJMPS.2022.121001]
[129]
Devi P, Singh M, Mehla R. H M A. Effect of Chlorophytum borivilianum supplementation on milk production, composition and fatty acid profile in crossbred cows during hot-humid season. Trop Anim Health Prod 2021; 53(2): 300.
[http://dx.doi.org/10.1007/s11250-021-02747-7] [PMID: 33931798]
[130]
P R, T P, S M. Ethnomedicinal plants and novel formulations used by Hooralis tribe in Sathyamangalam forests, Western Ghats of Tamil Nadu, India. J Med Plants Res 2013; 7(28): 2083-97.
[http://dx.doi.org/10.5897/JMPR2013.5074]
[131]
Rai MK. Ethno-medical studies of patalkot and tamiya (distt. Chhindwara) m. P. - plants used as tonic. Anc Sci Life 1987; 7(2): 119-21.
[PMID: 22557600]
[132]
Poonam K, Singh GS. Ethnobotanical study of medicinal plants used by the Taungya community in Terai Arc Landscape, India. J Ethnopharmacol 2009; 123(1): 167-76.
[http://dx.doi.org/10.1016/j.jep.2009.02.037] [PMID: 19429357]
[133]
Upadhyay B. Parveen, Dhaker AK, Kumar A. Ethnomedicinal and ethnopharmaco-statistical studies of Eastern Rajasthan, India. J Ethnopharmacol 2010; 129(1): 64-86.
[http://dx.doi.org/10.1016/j.jep.2010.02.026] [PMID: 20214972]
[134]
Narasimhan S, Govindarajan R, Vijayakumar M, Mehrotra S. Free radical scavenging potential of Chlorophytum tuberosum baker. J Ethnopharmacol 2006; 104(3): 423-5.
[http://dx.doi.org/10.1016/j.jep.2005.09.029] [PMID: 16271837]
[135]
Sainkhediya J, Ray S. Studies on the threatened ethnomedicinal plants used by tribals of harda district of M.P., India. Int J Sci Res 2014; 3(12): 2590-3.
[136]
Kaundal A, Devi RR. Infertility treatment using herbal drugs: A Review. Eur J Pharm Med Res 2016; 3(7): 194-201.

Rights & Permissions Print Cite
Article Metrics
5
2
© 2024 Bentham Science Publishers | Privacy Policy