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Current Indian Science

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ISSN (Print): 2210-299X
ISSN (Online): 2210-3007

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Review Article

Advancement of Nanocarriers-based Therapeutics for Effective Management of Colorectal Cancer

Author(s): Sumel Ashique*, Ashish Garg, Prashant Kumar, Neeraj Mishra, Afzal Hussain, Aakash Upadhyay, Shubneesh Kumar and Arshad Farid

Volume 1, 2023

Published on: 17 August, 2023

Article ID: e290523217410 Pages: 14

DOI: 10.2174/2210299X01666230529120441

open_access

Abstract

Background: Colorectal cancer is still challenging for scientists and healthcare professionals. Conventional treatment methods are associated with various limitations in clinical bed and patient compliance. However, novel nanocarrier-based approaches have opened a new window for improved therapy and a new future perspective.

Introduction: Cancer is the deadliest disease globally and is challenging to healthcare systems. Colorectal cancer (CRC) is the third most common cancer in the world, affecting all age groups and is the most common cancer in 23 countries, as per the World Health Organization (WHO).

Methods: In this review, we addressed the nanocarrier-based strategic treatment of colorectal cancer, along with major findings, limitations, and future perspectives. For this, we thoroughly reviewed several literatures downloaded from prime sources, such as google scholar, Web of Science, PubMed, and Publon. To filter the exact data needed, we used keywords alone or in combination. Various relevant articles were obtained from the reference section of the selected papers.

Result and Discussion: It is necessary to have an effective and targeted treatment option to control CRC other than available remedies. Nanotechnology has been widely used to diagnose and treat several cancer types. Advances in nanomedicine and phytonanomedicine have promoted novel identification methods to treat colorectal cancer patients. There are several nanocarriers recommended for clinical purposes. However, to date, only a few clinically approved nanocarriers can load anticancer moieties and selectively bind to cancer cells. Some nanocarriers transport and release treatments to the target colorectal area but provide few benefits.

Conclusion: In this review, various nanoparticles (NPs) with unique properties have been discussed in relation to managing colorectal cancer, along with major outcomes of clinical trials and successful patents published so far.

Keywords: Colorectal cancer, Nanocarriers, Phytomedicines, Clinical trials, Patents.

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