Abstract
Overexpression of epidermal growth factor receptor (EGFR) is seen in a number of human tumors like prostate, colon, breast and ovarian. Their expression is correlated with vascularity and often difficult to diagnose. Though a number of active inhibitors and anticancer drugs against EGFR-tyrosine kinase are known, increase in resistance together with many side effects designate the need for new and improved treatments. Natural products and their analoges have significant contribution in the cancer drug discovery and development process. Therefore in the current review we mainly discuss design, synthesis and structural activity relationship of epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors from the natural origin.
Keywords: Epidermal growth factor receptor, Natural origin, SAR.
Anti-Cancer Agents in Medicinal Chemistry
Title:Epidermal Growth Factor Receptor (EGFR) Tyrosine Kinase Inhibitors from the Natural Origin: A Recent Perspective
Volume: 15 Issue: 8
Author(s): Harun M. Patel, Rajesh Rane, Neeta Thapliyal, Mahesh Palkar, Mahamadhanif Shaikh and Rajshekhar Karpoormath
Affiliation:
Keywords: Epidermal growth factor receptor, Natural origin, SAR.
Abstract: Overexpression of epidermal growth factor receptor (EGFR) is seen in a number of human tumors like prostate, colon, breast and ovarian. Their expression is correlated with vascularity and often difficult to diagnose. Though a number of active inhibitors and anticancer drugs against EGFR-tyrosine kinase are known, increase in resistance together with many side effects designate the need for new and improved treatments. Natural products and their analoges have significant contribution in the cancer drug discovery and development process. Therefore in the current review we mainly discuss design, synthesis and structural activity relationship of epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors from the natural origin.
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Cite this article as:
Patel M. Harun, Rane Rajesh, Thapliyal Neeta, Palkar Mahesh, Shaikh Mahamadhanif and Karpoormath Rajshekhar, Epidermal Growth Factor Receptor (EGFR) Tyrosine Kinase Inhibitors from the Natural Origin: A Recent Perspective, Anti-Cancer Agents in Medicinal Chemistry 2015; 15 (8) . https://dx.doi.org/10.2174/1871520615666150312100259
DOI https://dx.doi.org/10.2174/1871520615666150312100259 |
Print ISSN 1871-5206 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5992 |
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