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Current Analytical Chemistry

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ISSN (Print): 1573-4110
ISSN (Online): 1875-6727

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Review Article

Analytical Methods for the Determination of Atypical Antipsychotic Drugs - An Update

Author(s): Vasanti Suvarna* and Adishri Raut

Volume 19, Issue 2, 2023

Published on: 27 December, 2022

Page: [147 - 175] Pages: 29

DOI: 10.2174/1573411019666221124091026

Price: $65

Abstract

Atypical antipsychotics have gained incredible attention over the last decade and are widely prescribed for short-term and chronic treatment of various psychopathological diseases, including schizophrenia, mania, delirium, bipolar disorder, depression, autism spectrum disorder, and affective disorders. Due to their better clinical profile and therapeutic benefits, atypical antipsychotics have become a better choice for psychopathological treatment and management. However, their usage is associated with peripheral side effects and metabolic diseases impacting the quality of life of patients. In the sight of these circumstances, strategic development of analytical methods to isolate atypical antipsychotics from a variety of formulations and biological samples and identify and quantify them with great sensitivity and accuracy is of great importance in clinical and forensic settings. In the present review, we have summarized and discussed various analytical methods reported in the literature over the last decade in various formulations and biological samples, highlighting analytical trends to the analysts in the field of atypical antipsychotics.

Keywords: Atypical antipsychotics, liquid chromatography, hyphenated techniques, schizophrenia, analytical method, bipolar disorder.

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