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Current Nutrition & Food Science

Editor-in-Chief

ISSN (Print): 1573-4013
ISSN (Online): 2212-3881

Mini-Review Article

Current Evidence on the Effect of Dietary Polyphenols Intake on Brain Health

Author(s): Stefania D'Angelo*

Volume 16, Issue 8, 2020

Page: [1170 - 1182] Pages: 13

DOI: 10.2174/1573401316999200714160126

Price: $65

Abstract

Background: In recent years, the possibility of favorably influencing the cognitive capacity through the promotion of lifestyle modifications has been increasingly investigated. In particular, the relationship between nutritional habits and brain health has attracted special attention. Polyphenols are secondary metabolites of plants. These phytochemicals are present in vegetables, fruits, legumes, olive oil, nuts. They include several antioxidant compounds and are generally considered to be involved in defense against chronic human diseases. In recent years, there has been a growing scientific interest in their potential health benefits to the brain.

Objective: In this mini-review, we focus on the current evidence defining the position of polyphenols dietary intake in the prevention/slowdown of human neurodegenerative diseases.

Methods: A literature research was performed using the keywords “polyphenols”, “brain”, “nutrition”, individually or all together, focusing on human trials.

Results: The available clinical studies on the effect of polyphenols on cognitive functions are quite convincing. Regular dietary intake of polyphenols would seem to reduce the risk of neurodegenerative diseases. Moreover, beyond their beneficial power on the central nervous system, these phytochemicals seem also to be able to work on numerous cellular targets. They show different biological actions, that however, have to be confirmed in long-term randomized clinical trials. Currently, most data propose that a combination of phytonutrients instead of any single polyphenol is responsible for health benefits.

Conclusion: Evolving indications suggest that dietary polyphenols may exercise beneficial actions on the central nervous system, thus representing a possible tool to preserve cognitive performance. Key questions to improve the coherence and reproducibility in the development of polyphenols as a possible future therapeutic drug require a better understanding of the sources of polyphenols, their treatment and more standardized tests including bioavailability of bioactive metabolites and studies of permeability of the brain.

Keywords: Antioxidants, brain, mediterranean diet, neurodegeneration, nutraceuticals, polyphenolic-food, polyphenols.

Graphical Abstract
[1]
Gillette-Guyonnet S, Secher M, Vellas B. Nutrition and neurodegeneration: epidemiological evidence and challenges for future research. Br J Clin Pharmacol 2013; 75(3): 738-55.https://www. ncbi.nlm.nih.gov/pmc/articles/PMC3575940/
[http://dx.doi.org/10.1111/bcp.12058] [PMID: 23384081]
[2]
D’Angelo S, Lembo S, Flora F, et al. Abnormal isoaspartyl residues in erythrocyte membranes from psoriatic patients. Arch Dermatol Res 2012; 304(6): 475-9.https://scholar.google.com/scholar? hl=en&as_sdt=0%2C5&q=Abnormal+isoaspartyl+residues+in+erythrocyte+membranes+from+psoriatic+patients.&btnG=
[http://dx.doi.org/10.1007/s00403-012-1247-z] [PMID: 22648381]
[3]
D’Angelo S, Trojsi F, Salvatore A, et al. Accumulation of altered aspartyl residues in erythrocyte membrane proteins from patients with sporadic amyotrophic lateral sclerosisNeurochem Int 2013; 63(6): 626-34.https://www.sciencedirect.com/science/article/pii/S0197018613002337?via%3Dihub
[http://dx.doi.org/10.1016/j.neuint.2013.09.006] [PMID: 24044898]
[4]
Galletti P, De Bonis ML, Sorrentino A, et al. Accumulation of altered aspartyl residues in erythrocyte proteins from patients with Down’s syndrome. FEBS J 2007; 274(20): 5263-77.https://febs. onlinelibrary.wiley.com/doi/full/10.1111/j.1742-4658.2007.06048.x
[http://dx.doi.org/10.1111/j.1742-4658.2007.06048.x PMID: 17892495]
[5]
Sies H. Oxidative stress: a concept in redox biology and medicine. Redox Biol 2015; 4: 180-3.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4309861/
[http://dx.doi.org/10.1016/j.redox.2015.01.002] [PMID: 25588755]
[6]
Maritim AC, Sanders RA, Watkins JB III. Diabetes, oxidative stress, and antioxidants: a review. J Biochem Mol Toxicol 2003; 17(1): 24-38.https://pdfs.semanticscholar.org/8789/be54f9980364 005a13ccd80190451e8a3a48.pdf
[http://dx.doi.org/10.1002/jbt.10058] [PMID: 12616644]
[7]
Rybka J, Kupczyk D, Kędziora-Kornatowska K, et al. Age-related changes in an antioxidant defense system in elderly patients with essential hypertension compared with healthy controls. Redox Rep 2011; 16(2): 71-7.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC 6837520/
[http://dx.doi.org/10.1179/174329211X13002357050897 PMID: 21722415]
[8]
Goñi I, Hernández-Galiot A. Intake of nutrient and non-nutrient dietary antioxidantsontribution of macromolecular antioxidant polyphenols in an elderly mediterranean population Nutrients 2019; 11(9)E2165https://www.ncbi.nlm.nih.gov/pmc/articles/PMC 6769609/
[http://dx.doi.org/10.3390/nu11092165] [PMID: 31509947]
[9]
Gómez-Pinilla F. Brain foods: the effects of nutrients on brain function. Nat Rev Neurosci 2008; 9(7): 568-78.https://www.ncbi. nlm.nih.gov/pmc/articles/PMC2805706/
[http://dx.doi.org/10.1038/nrn2421] [PMID: 18568016]
[10]
Serra-Majem L, Roman B, Estruch R. Scientific evidence of interventions using the Mediterranean diet: a systematic review. Nutr Rev 2006; 64(2 Pt 2): S27-47.https://academic.oup.com/nutrition reviews/article/64/suppl_1/S27/2258545
[http://dx.doi.org/10.1111/j.1753-4887.2006.tb00232.x PMID: 16532897]
[11]
Scarmeas N, Stern Y, Tang MX, Mayeux R, Luchsinger JA. Mediterranean diet and risk for Alzheimer’s disease. Ann Neurol 2006; 59(6): 912-21.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC 3024594/
[http://dx.doi.org/10.1002/ana.20854] [PMID: 16622828]
[12]
Gu Y, Brickman AM, Stern Y, et al. Mediterranean diet and brain structure in a multiethnic elderly cohort. Neurology 2015; 85(20): 1744-51.
[http://dx.doi.org/10.1212/WNL.0000000000002121 PMID: 26491085]
[13]
Aboul-Enein BH, Puddy WC, Bernstein J. Ancel Benjamin Keys (1904-2004): his early works and the legacy of the modern Mediterranean diet. J Med Biogr 2020; 28(3): 139-47.
[http://dx.doi.org/10.1177/0967772017727696] [PMID: 29134858]
[14]
Tourlouki E, Polychronopoulos E, Zeimbekis A, et al. The ‘secrets’ of the long livers in Mediterranean islands: the MEDIS study. Eur J Public Health 2010; 20(6): 659-64.
[http://dx.doi.org/10.1093/eurpub/ckp192] [PMID: 19948776]
[15]
Vasto S, Scapagnini G, Rizzo C, Monastero R, Marchese A, Caruso C. Mediterranean diet and longevity in Sicily: survey in a Sicani Mountains population. Rejuvenation Res 2012; 15(2): 184-8.
[http://dx.doi.org/10.1089/rej.2011.1280] [PMID: 22533429]
[16]
Buckland G, Agudo A, Travier N, et al. Adherence to the Mediterranean diet reduces mortality in the Spanish cohort of the European Prospective Investigation into Cancer and Nutrition (EPIC-Spain). Br J Nutr 2011; 106(10): 1581-91.
[http://dx.doi.org/10.1017/S0007114511002078] [PMID: 21736834]
[17]
McNaughton SA, Bates CJ, Mishra GD. Diet quality is associated with all-cause mortality in adults aged 65 years and older. J Nutr 2012; 142(2): 320-5.
[http://dx.doi.org/10.3945/jn.111.148692] [PMID: 22190031]
[18]
Tognon G, Rothenberg E, Eiben G, Sundh V, Winkvist A, Lissner L. Does the Mediterranean diet predict longevity in the elderly? A Swedish perspective. Age (Dordr) 2011; 33(3): 439-50.
[http://dx.doi.org/10.1007/s11357-010-9193-1] [PMID: 21110231]
[19]
Crous-Bou M, Fung TT, Prescott J, et al. Mediterranean diet and telomere length in Nurses’ Health Study: population based cohort study. BMJ 2014; 349: g6674.
[http://dx.doi.org/10.1136/bmj.g6674] [PMID: 25467028]
[20]
Di Daniele N, Noce A, Vidiri MF, et al. Impact of Mediterranean diet on metabolic syndrome, cancer and longevity. Oncotarget 2017; 8(5): 8947-79.
[http://dx.doi.org/10.18632/oncotarget.13553] [PMID: 27894098]
[21]
Luciano M, Corley J, Cox SR, et al. Mediterranean-type diet and brain structural change from 73 to 76 years in a Scottish cohort. Neurology 2017; 88: 449-55.
[http://dx.doi.org/10.1212/WNL.0000000000003559]
[22]
Misirli G, Benetou V, Lagiou P, Bamia C, Trichopoulos D, Trichopoulou A. Relation of the traditional Mediterranean diet to cerebrovascular disease in a Mediterranean population. Am J Epidemiol 2012; 176(12): 1185-92.
[http://dx.doi.org/10.1093/aje/kws205] [PMID: 23186748]
[23]
Yannakoulia M, Kontogianni M, Scarmeas N. Cognitive health and Mediterranean diet: just diet or lifestyle pattern? Ageing Res Rev 2015; 20: 74-8.
[http://dx.doi.org/10.1016/j.arr.2014.10.003] [PMID: 25461244]
[24]
Zbeida M, Goldsmith R, Shimony T, Vardi H, Naggan L, Shahar DR. Mediterranean diet and functional indicators among older adults in non-Mediterranean and Mediterranean countries. J Nutr Health Aging 2014; 18(4): 411-8.
[http://dx.doi.org/10.1007/s12603-014-0003-9] [PMID: 24676323]
[25]
Sofi F, Abbate R, Gensini GF, Casini A. Accruing evidence on benefits of adherence to the Mediterranean diet on health: an updated systematic review and meta-analysis. Am J Clin Nutr 2010; 92(5): 1189-96.
[http://dx.doi.org/10.3945/ajcn.2010.29673] [PMID: 20810976]
[26]
Féart C, Samieri C, Rondeau V, et al. Adherence to a Mediterranean diet, cognitive decline, and risk of dementia. JAMA 2009; 302(6): 638-48.
[http://dx.doi.org/10.1001/jama.2009.1146] [PMID: 19671905]
[27]
Knopman DS. Mediterranean diet and late-life cognitive impairment: a taste of benefit. JAMA 2009; 302(6): 686-7.
[http://dx.doi.org/10.1001/jama.2009.1149] [PMID: 19671912]
[28]
Martín.ez-Lapiscina EH, Clavero P, Toledo E, et al. . Mediterranean diet improves cognition: the PREDIMED-NAVARRA randomised trial. J Neurol Neurosurg Psychiatry 2013; 84: 1318-25.
[http://dx.doi.org/10.1136/jnnp-2012-304792.]
[29]
Gardener S, Gu Y, Rainey-Smith SR, et al. AIBL Research Group. Adherence to a Mediterranean diet and Alzheimer’s disease risk in an Australian population. Transl Psychiatry 2012; 2e164
[http://dx.doi.org/10.1038/tp.2012.91] [PMID: 23032941]
[30]
Martínez-González MA, Salas-Salvadó J, Estruch R, Corella D, Fitó M, Ros E. PREDIMED Investigators. Benefits of the Mediterranean diet: insights From the PREDIMED study. Prog Cardiovasc Dis 2015; 58(1): 50-60.
[http://dx.doi.org/10.1016/j.pcad.2015.04.003] [PMID: 25940230]
[31]
Valls-Pedret C, Sala-Vila A, Serra-Mir M, et al. Mediterranean diet and age-related cognitive decline: a randomized clinical trial. JAMA Intern Med 2015; 175(7): 1094-103.
[http://dx.doi.org/10.1001/jamainternmed.2015.1668 PMID: 25961184]
[32]
Rajaram S, Valls-Pedret C, Cofán M, et al. The Walnuts and Healthy Aging Study (WAHA): protocol for a nutritional intervention trial with walnuts on brain aging. Front Aging Neurosci 2017; 8: 333.
[http://dx.doi.org/10.3389/fnagi.2016.00333] [PMID: 28119602]
[33]
Vasto S, Barera A, Rizzo C, Di Carlo M, Caruso C, Panotopoulos G. Mediterranean diet and longevity: an example of nutraceuticals? Curr Vasc Pharmacol 2014; 12(5): 735-8.
[http://dx.doi.org/10.2174/1570161111666131219111818 PMID: 24350926]
[34]
D’Angelo S, Scafuro M, Meccariello R. BPA and nutraceuticals, simultaneous effects on endocrine functions. Endocr Metab Immune Disord Drug Targets 2019; 19(5): 594-604.
[http://dx.doi.org/10.2174/1871530319666190101120119] [PMID: 30621569]
[35]
D’Angelo S, Tafuri D. Nutraceutical: their role in improving sports performance. Sport Sci (Travnik) 2020; 13(Suppl. 1): 7-12.
[36]
Trichopoulou A. Traditional Mediterranean diet and longevity in the elderly: a review. Public Health Nutr 2004; 7(7): 943-7.
[http://dx.doi.org/10.1079/PHN2004558] [PMID: 15482622]
[37]
Huhn S, Kharabian Masouleh S, Stumvoll M, Villringer A, Witte AV. Components of a Mediterranean diet and their impact on cognitive functions in aging. Front Aging Neurosci 2015; 7: 132.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4495334/
[http://dx.doi.org/10.3389/fnagi.2015.00132] [PMID: 26217224]
[38]
Omar SH. Mediterranean and MIND Diets Containing Olive Biophenols Reduces the Prevalence of Alzheimer’s Disease . Int J Mol Sci 2019; 20(11)E2797. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6600544/
[http://dx.doi.org/10.3390/ijms20112797] [PMID: 31181669]
[39]
D’Angelo S, Cusano P. Adherence to the Mediterranean diet in athletes. Sport Sci (Travnik) 2020; 13(Suppl. 1): 58-63.
[40]
Namsi A, Nury T, Hamdouni H, et al. Induction of Neuronal Differentiation of Murine N2a Cells by Two Polyphenols Present in the Mediterranean Diet Mimicking Neurotrophins Activities: Resveratrol and Apigenin. Diseases 2018; 6(3)E67https://www.ncbi. nlm.nih.gov/pmc/articles/PMC6165409/
[http://dx.doi.org/10.3390/diseases6030067] [PMID: 30037152]
[41]
D’Innocenzo S, Biagi C, Lanari M. Obesity and the Mediterranean Diet: A Review of Evidence of the Role and Sustainability of the Mediterranean Diet. Nutrients 2019; 11(6)E1306https://www.ncbi. nlm.nih.gov/pmc/articles/PMC6627690/
[http://dx.doi.org/10.3390/nu11061306] [PMID: 31181836]
[42]
Gardener H, Caunca MR. Mediterranean Diet in Preventing Neurodegenerative Diseases. Curr Nutr Rep 2018; 7(1): 10-20.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7212497/
[http://dx.doi.org/10.1007/s13668-018-0222-5] [PMID: 29892785]
[43]
Román GC, Jackson RE, Gadhia R, Román AN, Reis J. Mediterranean diet: The role of long-chain ω-3 fatty acids in fish; polyphenols in fruits, vegetables, cereals, coffee, tea, cacao and wine; probiotics and vitamins in prevention of stroke, age-related cognitive decline, and Alzheimer disease. Rev Neurol (Paris). 2019; 175(10): 724-41.https://www.sciencedirect.com/science/article/pii/S0035378719307738
[http://dx.doi.org/10.1016/j.neurol.2019.08.005] [PMID: 31521398]
[44]
Manach C, Scalbert A, Morand C, Rémésy C, Jiménez L. Polyphenols: food sources and bioavailability. Am J Clin Nutr 2004; 79(5): 727-47.https://academic.oup.com/ajcn/article/79/5/727/4690182
[http://dx.doi.org/10.1093/ajcn/79.5.727] [PMID: 15113710]
[45]
Kelly E, Vyas P, Weber JT. Biochemical Properties and Neuroprotective Effects of Compounds in Various Species of Berries. Molecules 2017; 23(1): 26.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5943949/
[http://dx.doi.org/10.3390/molecules23010026] [PMID: 29271934]
[46]
Figueira I, Menezes R, Macedo D, Costa I, Dos Santos CN. Polyphenols Beyond Barriers: A Glimpse into the Brain. Curr Neuropharmacol 2017; 15(4): 562-94.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5543676/
[http://dx.doi.org/10.2174/1570159X14666161026151545 PMID: 27784225]
[47]
Santhakumar AB, Battino M, Alvarez-Suarez JM. Dietary polyphenols: Structures, bioavailability and protective effects against atherosclerosis. Food Chem Toxicol 2018; 113: 49-65.https://www.sciencedirect.com/science/article/pii/S027869151830022X?via%3Dihub
[http://dx.doi.org/10.1016/j.fct.2018.01.022] [PMID: 29360556]
[48]
Williamson G. The role of polyphenols in modern nutrition. Nutr Bull 2017; 42(3): 226-35.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5601283/
[http://dx.doi.org/10.1111/nbu.12278] [PMID: 28983192]
[49]
Slemmer JE, Weber JT. Assessing Antioxidant Capacity in Brain Tissue: Methodologies and Limitations in Neuroprotective Strategies. Antioxidants 2014; 3(4): 636-48.
[http://dx.doi.org/10.3390/antiox3040636] [PMID: 26785231]
[50]
Kelsey NA, Wilkins HM, Linseman DA. Nutraceutical antioxidants as novel neuroprotective agents. Molecules 2010; 15(11): 7792-814.
[http://dx.doi.org/10.3390/molecules15117792] [PMID: 21060289]
[51]
Bensalem J, Dudonné S, Etchamendy N, et al. Polyphenols from grape and blueberry improve episodic memory in healthy elderly with lower level of memory performance: a bicentric double-blind, randomized, placebo-controlled clinical study. J Gerontol A Biol Sci Med Sci 2019; 74(7): 996-1007.
[http://dx.doi.org/10.1093/gerona/gly166] [PMID: 30032176]
[52]
Gaudreault R, Mousseau N. Mitigating Alzheimer’s disease with natural polyphenols: a review. Curr Alzheimer Res 2019; 16(6): 529-43.
[http://dx.doi.org/10.2174/1567205016666190315093520 PMID: 30873922]
[53]
Winter AN, Bickford PC. Anthocyanins and their metabolites as therapeutic agents for neurodegenerative disease. Antioxidants 2019; 8(9)E333
[http://dx.doi.org/10.3390/antiox8090333] [PMID: 31443476]
[54]
Serino A, Salazar G. Protective role of polyphenols against vascular inflammation, aging and cardiovascular disease. Nutrients 2018; 11(1)E53
[http://dx.doi.org/10.3390/nu11010053] [PMID: 30597847]
[55]
Letenneur L, Proust-Lima C, Le Gouge A, Dartigues JF, Barberger-Gateau P. Flavonoid intake and cognitive decline over a 10-year period. Am J Epidemiol 2007; 165(12): 1364-71.
[http://dx.doi.org/10.1093/aje/kwm036] [PMID: 17369607]
[56]
Kesse-Guyot E, Fezeu L, Andreeva VA, et al. Total and specific polyphenol intakes in midlife are associated with cognitive function measured 13 years later. J Nutr 2012; 142(1): 76-83.
[http://dx.doi.org/10.3945/jn.111.144428] [PMID: 22090468]
[57]
Lim SY, Kwak YS. Effect of nutrients and exhaustive exercise on brain function. J Exerc Rehabil 2019; 15(3): 341-5.
[http://dx.doi.org/10.12965/jer.1938102.051] [PMID: 31316924]
[58]
Dai Q, Borenstein AR, Wu Y, Jackson JC, Larson EB. Fruit and vegetable juices and Alzheimer’s disease: the Kame Project. Am J Med 2006; 119(9): 751-9.
[http://dx.doi.org/10.1016/j.amjmed.2006.03.045] [PMID: 16945610]
[59]
Morillas-Ruiz JM, Rubio-Perez JM, Albaladejo MD, Zafrilla P, Parra S, Vidal-Guevara ML. Effect of an antioxidant drink on homocysteine levels in Alzheimer’s patients. J Neurol Sci 2010; 299(1-2): 175-8.
[http://dx.doi.org/10.1016/j.jns.2010.08.050] [PMID: 20850133]
[60]
Weinreb O, Mandel S, Amit T, Youdim MBH. Neurological mechanisms of green tea polyphenols in Alzheimer’s and Parkinson’s diseases. J Nutr Biochem 2004; 15(9): 506-16.
[http://dx.doi.org/10.1016/j.jnutbio.2004.05.002] [PMID: 15350981]
[61]
Morzelle MC, Salgado JM, Telles M, et al. Neuroprotective Effects of Pomegranate Peel Extract after Chronic Infusion with Amyloid-β Peptide in Mice. PLoS One 2016; 11(11)e0166123
[http://dx.doi.org/10.1371/journal.pone.0166123] [PMID: 27829013]
[62]
AlMatar M, Islam MR, Albarri O, Var I, Koksal F. Pomegranate as a possible treatment in reducing risk of developing wound healing, obesity, neurodegenerative disorders, and diabetes mellitus. Mini Rev Med Chem 2018; 18(6): 507-26.
[http://dx.doi.org/10.2174/1389557517666170419114722 PMID: 28425868]
[63]
D’Angelo S, Rosa R. The impact of supplementation with pomegranate fruit (Punica granatum L.) on sport performance. Sport Sci (Travnik) 2020; 13(Suppl. 1): 29-37.
[64]
Hartman RE, Shah A, Fagan AM, et al. Pomegranate juice decreases amyloid load and improves behavior in a mouse model of Alzheimer’s disease Neurobiol Dis 2006; 24(3): 506-15.. https://www. sciencedirect.com/science/article/pii/S0969996106002038?via%3Dihub
[http://dx.doi.org/10.1016/j.nbd.2006.08.006] [PMID: 17010630]
[65]
Bookheimer SY, Renner BA, Ekstrom A, et al. Pomegranate juice augments memory and FMRI activity in middle-aged and older adults with mild memory complaints. Evid Based Complement Alternat Med 2013; 2013946298https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3736548/
[http://dx.doi.org/10.1155/2013/946298] [PMID: 23970941]
[66]
Chan A, Shea TB. Dietary supplementation with apple juice decreases endogenous amyloid-beta levels in murine brain. J Alzheimers Dis 2009; 16(1): 167-71.
[http://dx.doi.org/10.3233/JAD-2009-0959] [PMID: 19158432]
[67]
D’Angelo S, Sammartino D. Protective effect of annurca apple extract against oxidative damage in human erythrocytes. Curr Nutr Food Sci 2015; 11: 248-56.
[http://dx.doi.org/10.2174/1573401311666150610210529]
[68]
D’Angelo S, La Porta R, Napolitano M, Galletti P, Quagliuolo L, Boccellino M. Effect of Annurca apple polyphenols on human HaCaT keratinocytes proliferation. J Med Food 2012; 15(11): 1024-31. a
[http://dx.doi.org/10.1089/jmf.2012.0076] [PMID: 22892038]
[69]
D’Angelo S, Martino E, Ilisso CP, Bagarolo ML, Porcelli M, Cacciapuoti G. Pro-oxidant and pro-apoptotic activity of polyphenol extract from Annurca apple and its underlying mechanisms in human breast cancer cells. Int J Oncol 2017; 51(3): 939-48.
[http://dx.doi.org/10.3892/ijo.2017.4088] [PMID: 28766690]
[70]
D’Angelo S, Martino E, Cacciapuoti G. Effects of Annurca apple (Malus pumila cv Annurca) polyphenols on breast cancer cells. Curr Nutr Food Sci 2019; 15: 745-51.
[http://dx.doi.org/10.2174/1573401315666190206142025]
[71]
Martino E, Vuoso DC, D’Angelo S, et al. Annurca apple polyphenol extract selectively kills MDA-MB-231 cells through ROS generation, sustained JNK activation and cell growth and survival inhibition. Sci Rep 2019; 9(1): 13045.
[http://dx.doi.org/10.1038/s41598-019-49631-x] [PMID: 31506575]
[72]
D’Angelo S, Cimmino A, Raimo M, Salvatore A, Zappia V, Galletti P. Effect of reddening-ripening on the antioxidant activity of polyphenol extracts from cv. ‘Annurca’ apple fruits. J Agric Food Chem 2007; 55(24): 9977-85.
[http://dx.doi.org/10.1021/jf071773a] [PMID: 17960886]
[73]
Vuoso DC, Porcelli M, Cacciapuoti G, D’Angelo S. Biological activity of MelAnnurca flesh apple biophenols. Curr Nutr Food Sci 2020; 16(8): 1149-62.
[http://dx.doi.org/10.2174/1573401316666200217113808]
[74]
Boccellino M, Quagliuolo L, D’Angelo S. Annurca apple biophenols’ effects in combination with cisplatin on A549 cells. Curr Nutr Food Sci 2020; 16. Epub ahead of print
[http://dx.doi.org/10.2174/1573401316999200504093028]
[75]
Chan A, Remington R, Kotyla E, Lepore A, Zemianek J, Shea TB. A vitamin/nutriceutical formulation improves memory and cognitive performance in community-dwelling adults without dementia. J Nutr Health Aging 2010; 14(3): 224-30.
[76]
Rubio-Perez JM, Albaladejo MD, Zafrilla P, Vidal-Guevara ML, Morillas-Ruiz JM. Effects of an antioxidant beverage on biomarkers of oxidative stress in Alzheimer’s patients. Eur J Nutr 2016; 55(6): 2105-16.
[http://dx.doi.org/10.1007/s00394-015-1024-9] [PMID: 26298312]
[77]
Rubio-Perez JM, Morillas-Ruiz JM. Serum cytokine profile in Alzheimer’s disease patients after ingestion of an antioxidant beverage. CNS Neurol Disord Drug Targets 2013; 12(8): 1233-41.
[http://dx.doi.org/10.2174/18715273113129990075 PMID: 23844688]
[78]
Remington R, Chan A, Lepore A, Kotlya E, Shea TB. Apple juice improved behavioral but not cognitive symptoms in moderate-to-late stage Alzheimer’s disease in an open-label pilot study. Am J Alzheimers Dis Other Demen 2010; 25(4): 367-71.
[http://dx.doi.org/10.1177/1533317510363470] [PMID: 20338990]
[79]
Tavares L, Figueira I, McDougall GJ, et al. Neuroprotective effects of digested polyphenols from wild blackberry species. Eur J Nutr 2013; 52(1): 225-36.
[http://dx.doi.org/10.1007/s00394-012-0307-7] [PMID: 22314351]
[80]
Krikorian R, Shidler MD, Nash TA, et al. Blueberry supplementation improves memory in older adults. J Agric Food Chem 2010; 58(7): 3996-4000.
[http://dx.doi.org/10.1021/jf9029332] [PMID: 20047325]
[81]
Miller MG, Hamilton DA, Joseph JA, Shukitt-Hale B. Dietary blueberry improves cognition among older adults in a randomized, double-blind, placebo-controlled trial. Eur J Nutr 2018; 57(3): 1169-80.
[http://dx.doi.org/10.1007/s00394-017-1400-8] [PMID: 28283823]
[82]
Andrade PB, Grosso C, Valentao P, Bernardo J. Flavonoids in neurodegeneration: limitations and strategies to cross CNS barriers. Curr Med Chem 2016; 23(36): 4151-74.
[http://dx.doi.org/10.2174/0929867323666160809094934 PMID: 27516197]
[83]
Krikorian R, Nash TA, Shidler MD, Shukitt-Hale B, Joseph JA. Concord grape juice supplementation improves memory function in older adults with mild cognitive impairment. Br J Nutr 2010; 103(5): 730-4.
[http://dx.doi.org/10.1017/S0007114509992364] [PMID: 20028599]
[84]
Gorji N, Moeini R, Memariani Z. Almond, hazelnut and walnut, three nuts for neuroprotection in Alzheimer’s disease: A neuropharmacological review of their bioactive constituents. Pharmacol Res 2018; 129: 115-27.
[http://dx.doi.org/10.1016/j.phrs.2017.12.003] [PMID: 29208493]
[85]
Del Monaco G, Officioso A, D’Angelo S, et al. Characterization of extra virgin olive oils produced with typical Italian varieties by their phenolic profile. Food Chem 2015; 184: 220-8.
[http://dx.doi.org/10.1016/j.foodchem.2015.03.071 PMID: 25872448]
[86]
Zappia V, Galletti P, Manna C, et al. Effects of Hydroxytyrosol on Cyclosporine Nephrotoxicity.In: Preedy V, Watson R, Eds Olives and Olive Oil in Health and Disease Prevention. Oxford: Academic Press 2010; pp. 1245-52.
[http://dx.doi.org/10.1016/B978-0-12-374420-3.00136-4]
[87]
D’Angelo S, Ingrosso D, Migliardi V, et al. Hydroxytyrosol, a natural antioxidant from olive oil, prevents protein damage induced by long-wave ultraviolet radiation in melanoma cells. Free Radic Biol Med 2005; 38(7): 908-19.
[http://dx.doi.org/10.1016/j.freeradbiomed.2004.12.015 PMID: 15749387]
[88]
Czirr E, Wyss-Coray T. The immunology of neurodegeneration. J Clin Invest 2012; 122(4): 1156-63.
[http://dx.doi.org/10.1172/JCI58656] [PMID: 22466657]
[89]
Barbaro B, Toietta G, Maggio R, et al. Effects of the olive-derived polyphenol oleuropein on human health. Int J Mol Sci 2014; 15(10): 18508-24.
[http://dx.doi.org/10.3390/ijms151018508] [PMID: 25318054]
[90]
Berr C, Portet F, Carriere I, et al. Olive oil and cognition: results from the three-city study. Dement Geriatr Cogn Disord 2009; 28(4): 357-64.
[http://dx.doi.org/10.1159/000253483] [PMID: 19887798]
[91]
Simini B. Serge Renaud: from French paradox to Cretan miracle. Lancet 2000; 355(9197): 48.
[http://dx.doi.org/10.1016/S0140-6736(05)71990-5 PMID: 10615898]
[92]
Caruana M, Cauchi R, Vassallo N. Putative Role of Red Wine Polyphenols against Brain Pathology in Alzheimer’s and Parkinson’s Disease Front Nutr 2016; 3: 31.gov/pmc/articles/PMC4981604/.
[http://dx.doi.org/10.3389/fnut.2016.00031] [PMID: 27570766]
[93]
Gomes BAQ, Silva JPB, Romeiro CFR, et al. Neuroprotective Mechanisms of Resveratrol in Alzheimer’s disease: role of SIRT1. Oxid Med Cell Longev 2018; 20188152373
[http://dx.doi.org/10.1155/2018/8152373] [PMID: 30510627]
[94]
Orgogozo JM, Dartigues JF, Lafont S, et al. Wine consumption and dementia in the elderly: a prospective community study in the Bordeaux area. Rev Neurol (Paris) 1997; 153(3): 185-92.https://pdfs.semanticscholar.org/0833/94b3d6c0fe01b04bad9d97e3f7d755debfd5.pdf
[PMID: 9296132]
[95]
Truelsen T, Thudium D, Grønbaek M. Copenhagen city heart study. Amount and type of alcohol and risk of dementia: the Copenhagen City Heart Study. Neurology 2002; 59(9): 1313-9.
[http://dx.doi.org/10.1212/01.WNL.0000031421.50369.E7] [PMID: 12427876]
[96]
Sawda C, Moussa C, Turner RS. Resveratrol for Alzheimer’s disease. Ann N Y Acad Sci 2017; 1403(1): 142-9.
[http://dx.doi.org/10.1111/nyas.13431] [PMID: 28815614]
[97]
Semba RD, Ferrucci L, Bartali B, et al. Resveratrol levels and all-cause mortality in older community-dwelling adults. JAMA Intern Med 2014; 174(7): 1077-84.
[http://dx.doi.org/10.1001/jamainternmed.2014.1582 PMID: 24819981]
[98]
Moussa C, Hebron M, Huang X, et al. Resveratrol regulates neuro-inflammation and induces adaptive immunity in Alzheimer’s disease. J Neuroinflammation 2017; 14(1): 1.https://www.ncbi.nlm.nih. gov/pmc/articles/PMC5234138/
[http://dx.doi.org/10.1186/s12974-016-0779-0] [PMID: 28086917]
[99]
Krikorian R, Boespflug EL, Fleck DE, et al. Concord grape juice supplementation and neurocognitive function in human aging. J Agric Food Chem 2012; 60(23): 5736-42.
[http://dx.doi.org/10.1021/jf300277g] [PMID: 22468945]
[100]
Clinical Trials gov US National library of Medicine. Available from: . https://clinicaltrials.gov/ct2/home

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