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Letters in Drug Design & Discovery

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ISSN (Print): 1570-1808
ISSN (Online): 1875-628X

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Research Article

The Therapeutic Potential of Panax Ginseng and Ginger on Postsurgical Adhesion Band Formation

Author(s): Seyedeh Elnaz Nazari, Ghazaleh Khalili-Tanha, Leila Mobasheri, Fereshteh Asgharzadeh, Hamideh Naimi, Moein Eskandari, Mohammad-Mostafa Askarnia-Faal, Seyed Mahdi Hassanian Mehr, Masoumeh Gharib, Hamid Reza Ghorbani, Mohsen Aliakbarian, Gordon A Ferns, Majid Khazaei* and Amir Avan*

Volume 20, Issue 10, 2023

Published on: 25 August, 2022

Page: [1585 - 1592] Pages: 8

DOI: 10.2174/1570180819666220630094320

Price: $65

Abstract

Background: Peritoneal adhesions (PA) are a common complication of abdominal operations. Previous studies indicate that inhibition of inflammation and fibrosis at sites of peritoneal damage may prevent the development of intra-abdominal adhesions. Zingiber officinalis Roscoe (ginger) and Panax ginseng (P. ginseng) are herbal products with antioxidant and anti-inflammatory effects that can have restorative properties.

Objective: This research aimed to examine the impact of ginger and P. ginseng on prevention of PA in a rat model after surgery.

Methods: Following a laparotomy, the wall of the cecum was rubbed to induce intra-abdominal adherence in Wistar rats. Ginger (400mg/kg) and P. ginseng (500mg/kg) were orally adminstered to the animals. The animals were sacrificed on the 10th day after surgery, and the Nair and Leach scoring system was used to assess adhesion. The microscopic histology of the induced cecal adhesions was evaluated. An enzyme-linked immunosorbent assay (ELISA) was used to determined tissue levels of transforming growth factor-beta (TGF-β) on homogenized PA tissue. Real-time PCR was performed to quantify the mRNA expression of IL-1β, TNF-α, Col 1a1, and Col 3a1 in rat tissue.

Results: The adhesion score and histopathological rating based on the Nair and Leach scoring criteria showed lower adhesion scores in the group of rats treated with P. ginseng compared to the control group (p<0.05). Treatment with ginger and P. ginseng was associated with reduced tissue level of TGF-β and mRNA expression of TNF-α and IL-1β. The gene expression level of Col 1a1 and Col 3a1 were markedly decreased in the P. ginseng group.

Conclusion: The study's outcome recommends that P. ginseng could be an effective agent for preventing the PA and inflammation during the post-operative stage.

Keywords: Postoperative adhesions, panax ginseng, ginger, inflammation, fibrosis, microscopic histology.

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