Abstract
In this study, a nonlinear quantitative structure-activity relationship model for the prediction of the IC50 of trisubstituted thiazoles as Cdc7 kinase inhibitors was developed by the gene expression programming (GEP). This model is based on five descriptors which were selected from the descriptors’ pool by heuristic method (HM). GEP rendered a good correlation between the experimental and predicted log (IC50) values with a correlation coefficient and a mean error of 0.85 and 0.22 for the training set, 0.84 and 0.39 for the testing set, respectively. The results indicate that this QSAR model has good predictive capability and it points to further optimization opportunities for Cdc7 kinase inhibitors.
Keywords: Gene expression programming, IC50, kinase inhibitors, quantitative structure activity relationship, cell division cycle 7, trisubstituted thiazoles.
Letters in Drug Design & Discovery
Title:Studies on the IC50 of Trisubstituted Thiazoles as Cdc7 Kinase Inhibitors
Volume: 13 Issue: 1
Author(s): Huazhen Yang, Xun Liu, Zhiling Ye, Fucheng Song, Lianhua Cui, Zhuang Yu, Hongzong Si and Honglin Zhai
Affiliation:
Keywords: Gene expression programming, IC50, kinase inhibitors, quantitative structure activity relationship, cell division cycle 7, trisubstituted thiazoles.
Abstract: In this study, a nonlinear quantitative structure-activity relationship model for the prediction of the IC50 of trisubstituted thiazoles as Cdc7 kinase inhibitors was developed by the gene expression programming (GEP). This model is based on five descriptors which were selected from the descriptors’ pool by heuristic method (HM). GEP rendered a good correlation between the experimental and predicted log (IC50) values with a correlation coefficient and a mean error of 0.85 and 0.22 for the training set, 0.84 and 0.39 for the testing set, respectively. The results indicate that this QSAR model has good predictive capability and it points to further optimization opportunities for Cdc7 kinase inhibitors.
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Cite this article as:
Yang Huazhen, Liu Xun, Ye Zhiling, Song Fucheng, Cui Lianhua, Yu Zhuang, Si Hongzong and Zhai Honglin, Studies on the IC50 of Trisubstituted Thiazoles as Cdc7 Kinase Inhibitors, Letters in Drug Design & Discovery 2016; 13 (1) . https://dx.doi.org/10.2174/1570180812999150713144215
DOI https://dx.doi.org/10.2174/1570180812999150713144215 |
Print ISSN 1570-1808 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-628X |
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