Heterocyclic Compounds as MDR Modulators

Title: Heterocyclic Compounds as MDR Modulators

Volume: 8 Issue: 2

Author(s): Gyorgy Hajos, Katalin Jemnitz, Zsuzsanna Riedl, Daniella Takacs and Zsuzsa Veres

Affiliation:

Keywords: MDR modulation, Heterocyclic, Imidazole, Quinoline, Tetrahydroisoquinoline, Phenothiazine, multidrug resistance (MDR), Pglycoprotein (P-gp), protozoan parasite, Nbenzylpiperazine, doxorubicin, 99mTc-tetrofosmin, fluorescence activity, paclitaxel, vincristine, colon carcinoma, cruciferous vegetables, fumitremorgin, mitoxanthrone, tissue polypeptide antigen-A, rhodamine, cyclosporine, tariquidar, anthranylamine, zosuquidar, severe combined immunodeficient (SCID), C6 glioblastoma cell, clomipramine, piperazine, dioxaphosphinane

Abstract: A survey on MDR modulators containing heterocyclic moiety in the chemical structure for the past 20 years is provided. The discussion of the particular active compound is classified according to the heterocyclic rings involved. The most important biological results are also summarized.

Cite this article as:

Hajos Gyorgy, Jemnitz Katalin, Riedl Zsuzsanna, Takacs Daniella and Veres Zsuzsa, Heterocyclic Compounds as MDR Modulators, Letters in Drug Design & Discovery 2011; 8 (2) . https://dx.doi.org/10.2174/157018011794183815