Abstract
HIV-specific protease inhibitors are fundamental antiviral drugs for people with HIV/AIDS. Hologram quantitative structure-activity relationships (HQSAR) were conducted on a class of 82 protease inhibitors. The final model obtained was used to predict the potency of 17 test set compounds. The predicted values were in good agreement with the experimental results.
Keywords: HIV, AIDS, Enzyme Inhibitors, QSAR, HQSAR
Letters in Drug Design & Discovery
Title: Hologram Quantitative Structure-Activity Relationships for a Class of Inhibitors of HIV-1 Protease
Volume: 4 Issue: 5
Author(s): Leonardo G. Ferreira, Andrei Leitao, Carlos A. Montanari and Adriano D. Andricopulo
Affiliation:
Keywords: HIV, AIDS, Enzyme Inhibitors, QSAR, HQSAR
Abstract: HIV-specific protease inhibitors are fundamental antiviral drugs for people with HIV/AIDS. Hologram quantitative structure-activity relationships (HQSAR) were conducted on a class of 82 protease inhibitors. The final model obtained was used to predict the potency of 17 test set compounds. The predicted values were in good agreement with the experimental results.
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Cite this article as:
Ferreira G. Leonardo, Leitao Andrei, Montanari A. Carlos and Andricopulo D. Adriano, Hologram Quantitative Structure-Activity Relationships for a Class of Inhibitors of HIV-1 Protease, Letters in Drug Design & Discovery 2007; 4 (5) . https://dx.doi.org/10.2174/157018007780867825
DOI https://dx.doi.org/10.2174/157018007780867825 |
Print ISSN 1570-1808 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-628X |
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