Abstract
The course of Kabachnik-Fields reaction in the synthesis of 3-substituted quinoline-based α-aminophosphonates under microwave irradiation has been investigated. Some unexpected monoester hydrogen phosphonate derivatives, obtained along with diethyl phosphonates by reaction of quinoline-3-carboxaldehyde and aniline as well as 3- aminoquinoline and benzaldehyde, respectively, with diethyl phosphite, have been analyzed and discussed.
Keywords: α-Aminophosphonate, quinoline, microwave-assisted reaction, Kabachnik-Fields reaction
Letters in Organic Chemistry
Title: Unexpected Course of Kabachnik-Fields Reaction in the Microwave Synthesis of Quinoline-Based α-Aminophosphonates
Volume: 6 Issue: 1
Author(s): Marina Juribasic, Laura Stella, Zeljko Marinic, Marijana Vinkovic, Pietro Traldi and Ljerka Tusek-Bozic
Affiliation:
Keywords: α-Aminophosphonate, quinoline, microwave-assisted reaction, Kabachnik-Fields reaction
Abstract: The course of Kabachnik-Fields reaction in the synthesis of 3-substituted quinoline-based α-aminophosphonates under microwave irradiation has been investigated. Some unexpected monoester hydrogen phosphonate derivatives, obtained along with diethyl phosphonates by reaction of quinoline-3-carboxaldehyde and aniline as well as 3- aminoquinoline and benzaldehyde, respectively, with diethyl phosphite, have been analyzed and discussed.
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Cite this article as:
Juribasic Marina, Stella Laura, Marinic Zeljko, Vinkovic Marijana, Traldi Pietro and Tusek-Bozic Ljerka, Unexpected Course of Kabachnik-Fields Reaction in the Microwave Synthesis of Quinoline-Based α-Aminophosphonates, Letters in Organic Chemistry 2009; 6 (1) . https://dx.doi.org/10.2174/157017809787003142
DOI https://dx.doi.org/10.2174/157017809787003142 |
Print ISSN 1570-1786 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6255 |
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