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Current HIV Research

Editor-in-Chief

ISSN (Print): 1570-162X
ISSN (Online): 1873-4251

The CD4C/HIVNef Transgenic Model of AIDS

Author(s): Paul Jolicoeur

Volume 9, Issue 7, 2011

Page: [524 - 530] Pages: 7

DOI: 10.2174/157016211798842062

Price: $65

Abstract

CD4C/HIVNef Tg mice express HIV-1 Nef in relevant target cells through the regulatory sequences of the human CD4 gene. These mice develop a severe disease showing many characteristics of human AIDS. A summary of the results obtained with these Tg mice is presented.

Keywords: HIV-1, Nef, mouse model, AIDS, SIV, HIVAN, CD4C/HIVNef, Transgene, Tg DC, AIDS-LIKE DISEASE


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