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Current Cancer Drug Targets

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ISSN (Print): 1568-0096
ISSN (Online): 1873-5576

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Mini-Review Article

Pathological Implications of Mucin Signaling in Metastasis

Author(s): Suresh Sulekha Dhanisha and Chandrasekharan Guruvayoorappan*

Volume 23, Issue 8, 2023

Published on: 11 May, 2023

Page: [585 - 602] Pages: 18

DOI: 10.2174/1568009623666230320121332

Price: $65

Abstract

The dynamic mucosal layer provides a selective protective barrier for the epithelial cells lining the body cavities. Diverse human malignancies exploit their intrinsic role to protect and repair epithelia for promoting growth and survival. Aberrant expression of mucin has been known to be associated with poor prognosis of many cancers. However, the emergence of new paradigms in the study of metastasis recognizes the involvement of MUC1, MUC4, MUC5AC, MUC5B, and MUC16 during metastasis initiation and progression. Hence mucins can be used as an attractive target in future diagnostic and therapeutic strategies. In this review, we discuss in detail about mucin family and its domains and the role of different mucins in regulating cancer progression and metastasis. In addition, we briefly discuss insights into mucins as a therapeutic agent.

Keywords: Mucin family, mucin domains, secretory mucins, transmembrane mucins, metastasis, biomarkers, therapeutic targets.

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Graphical Abstract

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