Abstract
Because of low immunogenicity, ease of modification, and inherent biosafety, peptides have been well recognized as vehicles to deliver therapeutic agents to targeted regions with improved pharmacokinetic characteristics. Enzyme-responsive self-assembled peptides (ERSAPs) show superiority over their naive forms due to their enhanced targeting efficacy and long-retention property. In this review, we have summarized recent advances in the therapeutic application of ERSAPs, mainly focusing on their self-therapeutic properties and potential as vehicles to deliver different drugs.
Keywords: Peptides, enzyme-responsive, supramolecular, in situ self-assembly, drug delivery, ERSAP.
Current Drug Delivery
Title:Advances in Enzyme-responsive Supramolecular In situ Self-assembled Peptide for Drug Delivery
Volume: 21
Author(s): Wentao Xu, Xiaowen Qin, Yang Liu, Jun Chen and Yuguang Wang*
Affiliation:
- College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou, Zhejiang, 310014, China
Keywords: Peptides, enzyme-responsive, supramolecular, in situ self-assembly, drug delivery, ERSAP.
Abstract: Because of low immunogenicity, ease of modification, and inherent biosafety, peptides have been well recognized as vehicles to deliver therapeutic agents to targeted regions with improved pharmacokinetic characteristics. Enzyme-responsive self-assembled peptides (ERSAPs) show superiority over their naive forms due to their enhanced targeting efficacy and long-retention property. In this review, we have summarized recent advances in the therapeutic application of ERSAPs, mainly focusing on their self-therapeutic properties and potential as vehicles to deliver different drugs.
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Cite this article as:
Xu Wentao, Qin Xiaowen, Liu Yang, Chen Jun and Wang Yuguang*, Advances in Enzyme-responsive Supramolecular In situ Self-assembled Peptide for Drug Delivery, Current Drug Delivery 2024; 21 () . https://dx.doi.org/10.2174/1567201820666230726151607
DOI https://dx.doi.org/10.2174/1567201820666230726151607 |
Print ISSN 1567-2018 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5704 |
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