Abstract
Recent studies suggest that overproduction of reactive oxygen and nitrogen species (ROS/RNS), lowered antioxidant defense of the body. Oxidative stress is damaging to DNA, lipids, proteins and many more vital macromolecules. Consequences of oxidative stress thought to contribute to the development of a wide range of diseases including Alzheimer's disease, Parkinson's disease, diabetes, rheumatoid arthritis, neurodegeneration in motor neuron diseases and many cancer types. Melatonin (MLT) is a powerful antioxidant with a particular role in the protection of nuclear and mitochondrial DNA. To find an improved antioxidant activity, developments of novel synthetic analogues are under investigation. These studies may offer a new progress and approach in antioxidant drug development as well as antioxidant chemistry. Therefore, we have been synthesizing novel MLT derivatives and investigating their antioxidant capacities. This review gives a brief knowledge about the MLT based analogue indole derivatives as potential antioxidants.
Keywords: Antioxidant, free radical, melatonin, indole, synthesis
Current Drug Delivery
Title:Melatonin and Synthetic Analogs as Antioxidants
Volume: 10 Issue: 1
Author(s): Sibel Suzen
Affiliation:
Keywords: Antioxidant, free radical, melatonin, indole, synthesis
Abstract: Recent studies suggest that overproduction of reactive oxygen and nitrogen species (ROS/RNS), lowered antioxidant defense of the body. Oxidative stress is damaging to DNA, lipids, proteins and many more vital macromolecules. Consequences of oxidative stress thought to contribute to the development of a wide range of diseases including Alzheimer's disease, Parkinson's disease, diabetes, rheumatoid arthritis, neurodegeneration in motor neuron diseases and many cancer types. Melatonin (MLT) is a powerful antioxidant with a particular role in the protection of nuclear and mitochondrial DNA. To find an improved antioxidant activity, developments of novel synthetic analogues are under investigation. These studies may offer a new progress and approach in antioxidant drug development as well as antioxidant chemistry. Therefore, we have been synthesizing novel MLT derivatives and investigating their antioxidant capacities. This review gives a brief knowledge about the MLT based analogue indole derivatives as potential antioxidants.
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Cite this article as:
Suzen Sibel, Melatonin and Synthetic Analogs as Antioxidants, Current Drug Delivery 2013; 10 (1) . https://dx.doi.org/10.2174/1567201811310010013
DOI https://dx.doi.org/10.2174/1567201811310010013 |
Print ISSN 1567-2018 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5704 |
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