Abstract
The low molecular weight GTP-binding protein RhoA regulates many cellular events, including cell migration, organization of the cytoskeleton, cell adhesion, progress through the cell cycle and gene expression. Physical forces influence these cellular processes in part by regulating RhoA activity through mechanotransduction of cell adhesion molecules (e.g. integrins, cadherins, Ig superfamily molecules). RhoA activity is regulated by guanine nucleotide exchange factors (GEFs) and GTPase activating proteins (GAPs) that are themselves regulated by many different signaling pathways. Significantly, the engagement of many cell adhesion molecules can affect RhoA activity in both positive and negative ways. In this brief review, we consider how RhoA activity is regulated downstream from cell adhesion molecules and mechanical force. Finally, we highlight the importance of mechanotransduction signaling to RhoA in normal cell biology as well as in certain pathological states.
Keywords: Actin, adhesion, cytoskeleton, GTPase, force, mechanotransduction, RhoA.
Current Molecular Medicine
Title:Regulation of RhoA Activity by Adhesion Molecules and Mechanotransduction
Volume: 14 Issue: 2
Author(s): R.J. Marjoram, E.C. Lessey and K. Burridge
Affiliation:
Keywords: Actin, adhesion, cytoskeleton, GTPase, force, mechanotransduction, RhoA.
Abstract: The low molecular weight GTP-binding protein RhoA regulates many cellular events, including cell migration, organization of the cytoskeleton, cell adhesion, progress through the cell cycle and gene expression. Physical forces influence these cellular processes in part by regulating RhoA activity through mechanotransduction of cell adhesion molecules (e.g. integrins, cadherins, Ig superfamily molecules). RhoA activity is regulated by guanine nucleotide exchange factors (GEFs) and GTPase activating proteins (GAPs) that are themselves regulated by many different signaling pathways. Significantly, the engagement of many cell adhesion molecules can affect RhoA activity in both positive and negative ways. In this brief review, we consider how RhoA activity is regulated downstream from cell adhesion molecules and mechanical force. Finally, we highlight the importance of mechanotransduction signaling to RhoA in normal cell biology as well as in certain pathological states.
Export Options
About this article
Cite this article as:
Marjoram R.J., Lessey E.C. and Burridge K., Regulation of RhoA Activity by Adhesion Molecules and Mechanotransduction, Current Molecular Medicine 2014; 14 (2) . https://dx.doi.org/10.2174/1566524014666140128104541
DOI https://dx.doi.org/10.2174/1566524014666140128104541 |
Print ISSN 1566-5240 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5666 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Nucleobase Modifications in Peptide Nucleic Acids
Current Topics in Medicinal Chemistry Frontier Lipid-Based Carrier Systems for Drug Targeting: A Laconic Review on Niosomes
Pharmaceutical Nanotechnology The Amyloid Cascade Hypothesis in Alzheimer’s Disease: It’s Time to Change Our Mind
Current Neuropharmacology Diabetes and Chronic Heart Failure: From Diabetic Cardiomyopathy to Therapeutic Approach
Endocrine, Metabolic & Immune Disorders - Drug Targets Chronic Hepatitis C in HIV-Infected Patients: Those Who More Need Therapy are Those Who Respond Less
Infectious Disorders - Drug Targets Structural Bioinformatics: Methods, Concepts and Applications to Blood Coagulation Proteins
Current Protein & Peptide Science Functional Neuroimaging Biomarkers in Migraine: Diagnostic, Prognostic and Therapeutic Implications
Current Medicinal Chemistry A traditional Chinese Medicine, YXQN, Reduces Amyloid-induced Cytotoxicity by Inhibiting Aβ42 Aggregation and Fibril Formation
Current Pharmaceutical Design Failure of Immune Homeostasis - The Consequences of Under and Over Reactivity
Current Drug Targets - Immune, Endocrine & Metabolic Disorders Patents in Targets and Drugs for Unbalanced Cytokine and Chemokine Network Mediated Disorders
Recent Patents on Inflammation & Allergy Drug Discovery Preface- Novel Targets for CNS Anti-Inflammatory Drug Development Interfering with Eicosanoid Formation
Current Medicinal Chemistry - Anti-Inflammatory & Anti-Allergy Agents Xanthine Derivatives as Agents Affecting Non-dopaminergic Neuroprotection in Parkinson’s Disease
Current Medicinal Chemistry Astrocytic Adrenoceptors: A Major Drug Target in Neurological and Psychiatric Disorders?
Current Drug Targets - CNS & Neurological Disorders Rhodanine as a Privileged Scaffold in Drug Discovery
Current Medicinal Chemistry Advances in Studies on Neurodegenerative Diseases and their Treatments
Current Topics in Medicinal Chemistry Role of Gut Microbiota in Human Health and Diseases
Current Nutrition & Food Science Neuroplasticity and its Relevance to Psychiatric Disorders
Current Psychopharmacology Alzheimers Disease: An Overview of Current and Emerging Therapeutic Strategies
Current Topics in Medicinal Chemistry Identification of Nuclear Proteins in Soybean Under Flooding Stress using Proteomic Technique
Protein & Peptide Letters Meldrum's Acid in Organic Synthesis, an Outlook to Reaction Media
Current Organic Chemistry