SATE Pronucleotide Approaches: An Overview
This review depicts in vitro and in vivo results obtained with nucleotide prodrugs (pronucleotides) bearing S-acyl-2-thioethyl (SATE) groups as esterase-labile phosphate protections. New developments are illustrated by the design of mononucleoside mixed phosphoester derivatives leading to the selective intracellular delivery of the corresponding 5'-mononucleotide through two different enzyme-mediated activation steps.
Keywords: antiviral; bioconversion; esterase; nucleotide; phosphoamidase; phosphoramidate; phosphotriester; prodrug
Document Type: Review Article
Affiliations: UMR 5625 CNRS-UM II,Universite Montpellier II, cc 008, place E. Bataillon, 34095 Montpellier cedex 05, France.
Publication date: 01 May 2004
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