Abstract
Antimitotic agents have been the most successful pharmacological agents for the treatment of cancer. The term "antimitotic agent" has traditionally been synonymous with tubulin-targeting compounds, but as a consequence of the large number of new compounds and mechanisms that have been identified recently, a much broader definition is currently needed. This review attempts to provide a broad overview of compounds and their cognate protein targets which result in a block in mitosis. Focus has been placed on agents that act directly on the mitotic machinery rather than on targets further upstream such as growth factor receptors.
Keywords: Microtubules, Paclitaxel, Epothilone A, malignant glioma cell lines, tubulin interacting agents, Vinca Alkaloids
Current Drug Targets
Title: Antimitotic Agents of Natural Origin
Volume: 7 Issue: 3
Author(s): Advait Nagle, Wooyoung Hur and Nathanael S. Gray
Affiliation:
Keywords: Microtubules, Paclitaxel, Epothilone A, malignant glioma cell lines, tubulin interacting agents, Vinca Alkaloids
Abstract: Antimitotic agents have been the most successful pharmacological agents for the treatment of cancer. The term "antimitotic agent" has traditionally been synonymous with tubulin-targeting compounds, but as a consequence of the large number of new compounds and mechanisms that have been identified recently, a much broader definition is currently needed. This review attempts to provide a broad overview of compounds and their cognate protein targets which result in a block in mitosis. Focus has been placed on agents that act directly on the mitotic machinery rather than on targets further upstream such as growth factor receptors.
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Cite this article as:
Nagle Advait, Hur Wooyoung and Gray S. Nathanael, Antimitotic Agents of Natural Origin, Current Drug Targets 2006; 7 (3) . https://dx.doi.org/10.2174/138945006776054933
DOI https://dx.doi.org/10.2174/138945006776054933 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
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