Mechanisms of the Quorum Sensing Systems of Pseudomonas aeruginosa: Host and Bacteria

Title:Mechanisms of the Quorum Sensing Systems of Pseudomonas aeruginosa: Host and Bacteria

Volume: 31

Author(s): Diana Flores-Percino, Estefanie Osorio-Llanes, Yanireth Sepulveda, Jairo Castellar-López, Ricardo Belón Madera, Wendy Rosales, Carlos Mario Meléndez and Evelyn Mendoza-Torres*

Affiliation:

• Faculty of Health Sciences, Grupo de Investigación Avanzada en Biomedicina, Universidad Libre Seccional Barranquilla, Barranquilla, Colombia

Keywords: Quorum sensing, Pseudomonas aeruginosa, LasI/R system, virulence genes, Host cell.

Abstract: Quorum-sensing is a communication mechanism between bacteria with the ability to activate signaling pathways in the bacterium and in the host cells. Pseudomonas aeruginosa is a pathogen with high clinical relevance due to its vast virulence factors repertory and wide antibiotic resistance mechanisms. Due to this, it has become a pathogen of interest for developing new antimicrobial agents in recent years. P. aeruginosa has three major QS systems that regulate a wide gene range linked with virulence factors, metabolic regulation, and environment adaption. Consequently, inhibiting this communication mechanism would be a strategy to prevent the pathologic progression of the infections caused by this bacterium. In this review, we aim to overview the current studies about the signaling mechanisms of the QS system of P. aeruginosa and its effects on this bacterium and the host.

Cite this article as:

Flores-Percino Diana, Osorio-Llanes Estefanie, Sepulveda Yanireth, Castellar-López Jairo, Belón Madera Ricardo, Rosales Wendy, Meléndez Mario Carlos and Mendoza-Torres Evelyn*, Mechanisms of the Quorum Sensing Systems of Pseudomonas aeruginosa: Host and Bacteria, Current Medicinal Chemistry 2024; 31 () . https://dx.doi.org/10.2174/0929867331666230821110440