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Current Medicinal Chemistry

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ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

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Perspective

First Approval of Elacestrant as a Selective Estrogen Receptor Degrader for the Treatment of Metastatic Breast Cancer

Author(s): Surya K. De*

Volume 31, Issue 7, 2024

Published on: 15 June, 2023

Page: [791 - 795] Pages: 5

DOI: 10.2174/0929867330666230504152352

Abstract

Elacestrant was approved by the US FDA on January 27, 2023, for treating postmenopausal women or adult men with estrogen receptor (ER)-positive, HER2- negative, ESR1-mutated advanced or metastatic breast cancer with disease progression prior to using at least one line of endocrine therapy. In this short perspective, physicochemical properties, dosage and administration, mechanism of action, pharmacodynamics, pharmacokinetics, drug interaction, and treatment-related adverse reactions of elacestrant are summarized.

Keywords: Selective estrogen receptor degraders, elacestrant, giredestrant, fulvestrant tamoxifen, endocrine therapy, estrogen receptor 1 gene.

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