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Current Medicinal Chemistry

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ISSN (Online): 1875-533X

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Review Article

The Effect of Statins on the Differentiation and Function of Central Nervous System Cells

Author(s): Sajjad Chamani, Leila Mobasheri, Shadi Zerehpoosh, Ali Naghizadeh, Alice P. McCloskey, Manfredi Rizzo, Tannaz Jamialahmadi and Amirhossein Sahebkar*

Volume 31, Issue 11, 2024

Published on: 12 May, 2023

Page: [1348 - 1360] Pages: 13

DOI: 10.2174/0929867330666230308121645

Price: $65

Abstract

Statins (3-hydroxy-3-methylglutaryl-CoA reductase inhibitors) reduce plasma cholesterol and improve endothelium-dependent vasodilation, inflammation, and oxidative stress. The effect of statins on the central nervous system (CNS), particularly on cognition and neurological disorders such as cerebral ischemic stroke, multiple sclerosis (MS), and Alzheimer’s disease (AD), has received increasing attention in recent years, both within the scientific community and in the media. This review aims to provide an updated discussion on the effects of statins on the differentiation and function of various nervous system cells, including neurons and glial cells. Additionally, the mechanisms of action and how different types of statins enter the CNS will be discussed.

Keywords: Statins, neurodegeneration, pleiotropic effect, central nervous system, inflammation, plasma cholesterol.

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