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Current Medicinal Chemistry

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ISSN (Online): 1875-533X

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Review Article

Targeting Mitochondria for the Prevention and Treatment of Nonalcoholic Fatty Liver Disease: Polyphenols as a Non-pharmacological Approach

Author(s): Jaime Zapata, Mauricio Castro-Sepulveda, Sandra Soto-Alarcon, Daniela Alvarez, Andres Bustamante, Guiselle Villarroel, Arturo Gallardo, Diego Fernando Garcia-Diaz, Rodrigo Valenzuela and Francisca Echeverria*

Volume 30, Issue 26, 2023

Published on: 08 November, 2022

Page: [2977 - 2995] Pages: 19

DOI: 10.2174/0929867329666221007115809

Price: $65

Abstract

Scope: Nonalcoholic fatty liver disease (NAFLD) has a high and growing prevalence globally. Mitochondria are fundamental in regulating cell energy homeostasis. Nevertheless, mitochondria control mechanisms can be exceeded in this context of energy overload. Damaged mitochondria worsen NAFLD progression. Diet and lifestyle changes are the main recommendations for NAFLD prevention and treatment. Some polyphenols have improved mitochondrial function in different NAFLD and obesity models.

Objective: The study aims to discuss the potential role of polyphenols as a nonpharmacological approach targeting mitochondria to prevent and treat NAFLD, analyzing the influence of polyphenols' chemical structure, limitations and clinical projections.

Methods: In vivo and in vitro NAFLD models were considered. Study searches were performed using the following keywords: nonalcoholic fatty liver disease, liver steatosis, mitochondria, mitochondrial activity, mitochondrial dynamics, mitochondrial dysfunction, mitochondrial morphology, mitochondrial cristae, fusion, fission, polyphenols, flavonoids, anthocyanins, AND/OR bioactive compounds.

Conclusion: Polyphenols are a group of diverse bioactive molecules whose bioactive effects are highly determined by their chemical structure. These bioactive compounds could offer an interesting non-pharmacological approach to preventing and treating NAFLD, regulating mitochondrial dynamics and function. Nevertheless, the mitochondria' role in subjects with NAFLD treatment is not fully elucidated. The dosage and bioavailability of these compounds should be addressed when studied.

Keywords: Bioactive compounds, liver steatosis, mitochondrial dysfunction, obesity, phenolic compounds.

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