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Current Medicinal Chemistry

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ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

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Review Article

Lipophagy: A Potential Therapeutic Target for Diabetic Nephropathy

Author(s): Ming Yang, Panai Song, Li Zhao and Xi Wang*

Volume 30, Issue 16, 2023

Published on: 04 October, 2022

Page: [1875 - 1886] Pages: 12

DOI: 10.2174/0929867329666220727113129

Price: $65

Abstract

Diabetic nephropathy (DN) is a serious complication of diabetes mellitus and one of the main causes of end-stage renal disease (ESRD). There are many factors causing the progression of DN. Lipid metabolism disorder is a common clinical manifestation of DN, and ectopic renal lipid deposition was recently proposed as a key factor promoting the development of DN. Lipophagy is a newly discovered type of selective autophagy that can remove excessive lipids in cells to maintain lipid homeostasis. Recently, abnormalities in lipophagy have also been implicated in the progression of DN. Here, we discuss the formation of lipid droplets, describe lipophagy and its key regulatory signals, summarize the current research progress of lipophay in DN, and finally propose that lipophagy may be a potential target for the treatment of DN.

Keywords: Diabetic nephropathy (DN), lipophagy, lipid droplet, lipid homeostasis, autophagy, kidney.

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