Abstract
Quercetin (QC) is a typical plant flavonoid, possesses diverse pharmacologic effects including antiinflammatory, antioxidant, anti-cancer, anti-anaphylaxis effects and against aging. However, the application of QC in pharmaceutical field is limited due to its poor solubility, low bioavailability, poor permeability and instability. To improve the bioavailability of QC, numerous approaches have been undertaken, involving the use of promising drug delivery systems such as inclusion complexes, liposomes, nanoparticles or micelles, which appear to provide higher solubility and bioavailability. Enhanced bioavailability of QC in the near future is likely to bring this product to the forefront of therapeutic agents for treatment of human disease.
Keywords: Bioavilability, formulations, inclusion complexes, liposomes, micelles, nanoparticles, prodrug, quercetin, solubility.
Current Medicinal Chemistry
Title:Bioavailability of Quercetin: Problems and Promises
Volume: 20 Issue: 20
Author(s): X. Cai, Z. Fang, J. Dou, A. Yu and G. Zhai
Affiliation:
Keywords: Bioavilability, formulations, inclusion complexes, liposomes, micelles, nanoparticles, prodrug, quercetin, solubility.
Abstract: Quercetin (QC) is a typical plant flavonoid, possesses diverse pharmacologic effects including antiinflammatory, antioxidant, anti-cancer, anti-anaphylaxis effects and against aging. However, the application of QC in pharmaceutical field is limited due to its poor solubility, low bioavailability, poor permeability and instability. To improve the bioavailability of QC, numerous approaches have been undertaken, involving the use of promising drug delivery systems such as inclusion complexes, liposomes, nanoparticles or micelles, which appear to provide higher solubility and bioavailability. Enhanced bioavailability of QC in the near future is likely to bring this product to the forefront of therapeutic agents for treatment of human disease.
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Cite this article as:
Cai X., Fang Z., Dou J., Yu A. and Zhai G., Bioavailability of Quercetin: Problems and Promises, Current Medicinal Chemistry 2013; 20 (20) . https://dx.doi.org/10.2174/09298673113209990120
DOI https://dx.doi.org/10.2174/09298673113209990120 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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