Abstract
In 1977 the neuropeptide FMRFamide was isolated from the clam, Macrocallista nimbosa. Since then several hundred FMRFamide-related peptides (FaRPs) have been isolated from invertebrate animals. Precursors to the FaRPs likely arose in the cnidarians. With the transition to a bilateral body plan FaRPs became a fixture in the invertebrate phyla. They have come to play a critical role as neurotransmitters, neuromodulators, and neurohormones. FaRPs regulate a variety of body functions including, feeding, digestion, circulation, reproduction, movement. The evolution of the molecular form and function of these omnipresent peptides will be considered.
Keywords: FMRFamide, FaRPs, cnidaria, platyhelminthes, nematoda, annelida, mollusca, arthropoda.
Protein & Peptide Letters
Title:Invertebrate FMRFamide Related Peptides
Volume: 20 Issue: 6
Author(s): Kevin G. Krajniak
Affiliation:
Keywords: FMRFamide, FaRPs, cnidaria, platyhelminthes, nematoda, annelida, mollusca, arthropoda.
Abstract: In 1977 the neuropeptide FMRFamide was isolated from the clam, Macrocallista nimbosa. Since then several hundred FMRFamide-related peptides (FaRPs) have been isolated from invertebrate animals. Precursors to the FaRPs likely arose in the cnidarians. With the transition to a bilateral body plan FaRPs became a fixture in the invertebrate phyla. They have come to play a critical role as neurotransmitters, neuromodulators, and neurohormones. FaRPs regulate a variety of body functions including, feeding, digestion, circulation, reproduction, movement. The evolution of the molecular form and function of these omnipresent peptides will be considered.
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Cite this article as:
Krajniak Kevin G., Invertebrate FMRFamide Related Peptides, Protein & Peptide Letters 2013; 20 (6) . https://dx.doi.org/10.2174/0929866511320060005
DOI https://dx.doi.org/10.2174/0929866511320060005 |
Print ISSN 0929-8665 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5305 |
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