Insights on the Structure of Amyloid Fibrils from Site-Directed Mutagenesis

Title: Insights on the Structure of Amyloid Fibrils from Site-Directed Mutagenesis

Volume: 16 Issue: 12

Author(s): Daniel Henrique do Amaral Correa and Carlos Henrique Inacio Ramos

Affiliation:

Keywords: Amyloid fibrils, protein folding, site-directed mutagenesis, intermediate, apomyoglobin

Abstract: To test the hypothesis that the ability to form ordered β-rich amyloid fibers with identical structures is a generic property of proteins we present a study on the overall structures of fibers formed by apomyoglobin mutants that either stabilize or destabilize the native state or the intermediate. Our results indicate that, at least at the macroscopic level, ordered β-rich amyloid fibers have similar structures.

Cite this article as:

Correa do Amaral Daniel Henrique and Inacio Ramos Henrique Carlos, Insights on the Structure of Amyloid Fibrils from Site-Directed Mutagenesis, Protein & Peptide Letters 2009; 16 (12) . https://dx.doi.org/10.2174/092986609789839223