Abstract
Phospholipases A2 homologues are found in the venom of Crotalinae snakes, being their main action related to myonecrosis induction. Although many studies on these toxins had already been performed, their mechanism of action remains unclear. Here, important aspects about these toxins are reviewed, including their correct biological assembly and how essential is the natural substitution D49K for their catalytic inactivity.
Keywords: Phospholipase A2 homologues, snake venom, oligomeric conformation, quaternary structure, myotoxicity, X-ray crystallography
Protein & Peptide Letters
Title: The Intriguing Phospholipases A2 Homologues: Relevant Structural Features on Myotoxicity and Catalytic Inactivity
Volume: 16 Issue: 8
Author(s): Juliana I. dos Santos, Carlos A.H. Fernandes, Angelo J. Magro and Marcos R.M. Fontes
Affiliation:
Keywords: Phospholipase A2 homologues, snake venom, oligomeric conformation, quaternary structure, myotoxicity, X-ray crystallography
Abstract: Phospholipases A2 homologues are found in the venom of Crotalinae snakes, being their main action related to myonecrosis induction. Although many studies on these toxins had already been performed, their mechanism of action remains unclear. Here, important aspects about these toxins are reviewed, including their correct biological assembly and how essential is the natural substitution D49K for their catalytic inactivity.
Export Options
About this article
Cite this article as:
dos Santos I. Juliana, Fernandes A.H. Carlos, Magro J. Angelo and Fontes R.M. Marcos, The Intriguing Phospholipases A2 Homologues: Relevant Structural Features on Myotoxicity and Catalytic Inactivity, Protein & Peptide Letters 2009; 16 (8) . https://dx.doi.org/10.2174/092986609788923310
DOI https://dx.doi.org/10.2174/092986609788923310 |
Print ISSN 0929-8665 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5305 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Influence of Drugs on Mild Cognitive Impairment in Parkinson’s Disease:
Evidence from the PACOS Study
Current Neuropharmacology Graphical Abstracts
Inflammation & Allergy - Drug Targets (Discontinued) Stress Echocardiography
Current Pharmaceutical Design Ebola and Marburg Viruses: Pathogenesis and Development of Countermeasures
Current Molecular Medicine The Use of Ghrelin and Ghrelin Receptor Agonists as a Treatment for Animal Models of Disease: Efficacy and Mechanism
Current Pharmaceutical Design Evaluation of Endothelial (dys)Function, Left Ventricular Structure and Function in Patients with Chronic Kidney Disease
Current Vascular Pharmacology Cognitive Decline as a Consequence of Essential Hypertension
Current Pharmaceutical Design Scope and Limitations of The Co-Drug Approach to Topical Drug Delivery
Current Pharmaceutical Design An Exceptional Case of Atrial Fibrillation Arrhythmia Induced by Etoposide
Current Drug Safety New Antihypertensive Drugs Under Development
Current Medicinal Chemistry Effect of Depression on Self-Management Behaviors and Health Outcomes in Adults with Type 2 Diabetes
Current Diabetes Reviews A Comprehensive Review on Phytochemistry and Pharmacological Effects of Stinging Nettle (Urtica dioica)
Current Traditional Medicine Medication-Induced Nephrotoxicity in Older Patients
Current Drug Metabolism Invasive aspergillosis: adjunctive combination therapy
Mini-Reviews in Medicinal Chemistry Nanocrystalline ZnO: A Competent and Reusable Catalyst for the Preparation of Pharmacology Relevant Heterocycles in the Aqueous Medium
Current Green Chemistry The Relationship Between 24-Hour Indicators and Mortality in Patients with Exertional Heat Stroke
Endocrine, Metabolic & Immune Disorders - Drug Targets The Role of Corticosteroids in Sepsis and Acute Respiratory Distress Syndrome
Current Respiratory Medicine Reviews Antiplatelet Treatment in Ischemic Stroke Treatment
Current Topics in Medicinal Chemistry The Immunosuppressive Role of Adenosine A2A Receptors in Ischemia Reperfusion Injury and Islet Transplantation
Current Diabetes Reviews Midazolam Plus Haloperidol as Adjuvant Analgesics to Morphine in Opium Dependent Patients: A Randomized Clinical Trial
Current Drug Abuse Reviews