New Hydrogen Donor: A Facile Method for the Removal of Hydrogenolysable Protecting Groups in Peptide Synthesis.

D.   Channe   Gowda; B.      Mahesh

Abstract

Removal of some commonly used protecting groups in peptide synthesis by catalytic transfer hydrogenation employing hydrazinium monoformate and 10%Pd on carbon is described. This method is equally competitive with other methods in deblocking most of the commonly used protecting groups in peptide synthesis. tert-Butyl derived and base labile protecting groups were completely stable under these conditions. This is more effective than hydrazine or formic acid.

Keywords: catalytic transfer hydrogenation, hydrazinium monoformate, new hydrogen donor, deprotection

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Protein & Peptide Letters

Title: New Hydrogen Donor: A Facile Method for the Removal of Hydrogenolysable Protecting Groups in Peptide Synthesis.

Volume: 9 Issue: 3

Author(s): D. Channe Gowda and B. Mahesh

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Keywords: catalytic transfer hydrogenation, hydrazinium monoformate, new hydrogen donor, deprotection

Abstract: Removal of some commonly used protecting groups in peptide synthesis by catalytic transfer hydrogenation employing hydrazinium monoformate and 10%Pd on carbon is described. This method is equally competitive with other methods in deblocking most of the commonly used protecting groups in peptide synthesis. tert-Butyl derived and base labile protecting groups were completely stable under these conditions. This is more effective than hydrazine or formic acid.

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Gowda Channe D. and Mahesh B., New Hydrogen Donor: A Facile Method for the Removal of Hydrogenolysable Protecting Groups in Peptide Synthesis., Protein & Peptide Letters 2002; 9 (3) . https://dx.doi.org/10.2174/0929866023408733