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Endocrine, Metabolic & Immune Disorders - Drug Targets

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ISSN (Print): 1871-5303
ISSN (Online): 2212-3873

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Research Article

Association of Anxiety and Depressive Symptoms with Thyroid Hormone Concentrations in Patients with Primary Bone Tumors

Author(s): Man Ao, Kun Xu, Yujun Pan, Shuping Wang and Guoquan Fu*

Volume 24, Issue 8, 2024

Published on: 06 November, 2023

Page: [902 - 908] Pages: 7

DOI: 10.2174/0118715303238500231101051257

Price: $65

Abstract

Background: Timely identification and intervention of psychological disorders bear significant import in ameliorating the ensuing therapeutic trajectories in primary bone tumor patients. Moreover, perturbations in thyroxine and thyroid-stimulating hormone (TSH) levels have been linked to manifestations of depressive and anxiety-related symptoms. However, the precise interplay governing the nexus of anxiety, depression, and the levels of thyroxine and TSH within the context of primary bone tumor patients remains presently unexplored.

Objective: The objective of this study is to investigate the potential correlation between the hypothalamus- pituitary-thyroxine (HPT) axis and the depressive as well as anxious states observed in patients afflicted with bone tumors.

Methods: Patients with primary bone tumors were required to accept the assessments of anxiety and depressive symptoms as well as thyroid axis hormone concentrations. The depressive and anxiety symptoms were assessed using the Hamilton Depression Rating Scale (HAMD) and the Hamilton Anxiety Scale (HAMA) score. During each follow-up, peripheral venous blood samples were collected for subsequent analysis using radioimmunoassay methods to measure serum- free T3, free T4, and TSH levels, with the calculated free T3 to free T4 ratio indicating peripheral free T4 to free T3 conversion. Tests for trend were conducted to assess thyroid axis hormone concentrations, HAMA scores, and HAMD scores, while the correlation between HAMA or HAMD scores and thyroid axis hormone concentrations was examined through univariate regression analyses.

Results: The study included 30 primary bone tumor patients. Initial high HAMA and HAMD scores decreased over a year after surgery (P < 0.05), reflecting diminishing anxiety and depression. TSH levels reduced postoperatively, contrasting with increased free-T3 and free-T4 levels (p < 0.01). Multivariate analysis affirmed that positive correlations were noted between TSH and anxiety/depression scores, while free-T3 correlated negatively, adjusted for demographic factors (p < 0.05). No significant associations emerged between HAMA/HAMD scores and free-T4 or free-T3 to free-T4 ratio (p > 0.05).

Conclusion: The early identification of the low T3 syndrome could prove instrumental in both intervening and preventing adverse emotional states associated with primary bone tumors.

Keywords: Primary bone tumors, thyroid hormone concentrations, anxiety and depressive symptoms, TSH, psychological disorders, hypothalamus-pituitary-thyroxine (HPT).

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[1]
De Salvo, S.; Pavone, V.; Coco, S.; Dell’Agli, E.; Blatti, C.; Testa, G. Benign Bone Tumors: An Overview of What We Know Today. J. Clin. Med., 2022, 11(3), 699.
[http://dx.doi.org/10.3390/jcm11030699] [PMID: 35160146]
[2]
Shao, R.; Wang, Y.; Li, L.; Dong, Y.; Zhao, J.; Liang, W. Bone tumors effective therapy through functionalized hydrogels: Current developments and future expectations. Drug Deliv., 2022, 29(1), 1631-1647.
[http://dx.doi.org/10.1080/10717544.2022.2075983] [PMID: 35612368]
[3]
Arrigoni, F.; Bruno, F.; Zugaro, L.; Natella, R.; Cappabianca, S.; Russo, U.; Papapietro, V.R.; Splendiani, A.; Di Cesare, E.; Masciocchi, C.; Barile, A. Developments in the management of bone metastases with interventional radiology. Acta Biomed., 2018, 89(1-S), 166-174.
[http://dx.doi.org/10.23750/abm.v89i1-S.7020] [PMID: 29350645]
[4]
Ise, M.; Nakata, E.; Katayama, Y.; Hamada, M.; Kunisada, T.; Fujiwara, T.; Nakahara, R.; Takihira, S.; Sato, K.; Akezaki, Y.; Senda, M.; Ozaki, T. Prevalence of psychological distress and its risk factors in patients with primary bone and soft tissue tumors. Healthcare (Basel), 2021, 9(5), 566.
[http://dx.doi.org/10.3390/healthcare9050566] [PMID: 34065006]
[5]
Kennifer, S.L.; Alexander, S.C.; Pollak, K.I.; Jeffreys, A.S.; Olsen, M.K.; Rodriguez, K.L.; Arnold, R.M.; Tulsky, J.A. Negative emotions in cancer care: Do oncologists’ responses depend on severity and type of emotion? Patient Educ. Couns., 2009, 76(1), 51-56.
[http://dx.doi.org/10.1016/j.pec.2008.10.003] [PMID: 19041211]
[6]
Martins, A.; Whelan, J.S.; Bennister, L.; Fern, L.A.; Gerrand, C.; Onasanya, M.; Storey, L.; Wells, M.; Windsor, R.; Woodford, J.; Taylor, R.M. Qualitative study exploring patients experiences of being diagnosed and living with primary bone cancer in the UK. BMJ Open, 2019, 9(9), e028693.
[http://dx.doi.org/10.1136/bmjopen-2018-028693] [PMID: 31551374]
[7]
Maki, Y.; Horiuchi, K.; Okamoto, T. Fatigue and quality of life among thyroid cancer survivors without persistent or recurrent disease. Endocr. Connect., 2022, 11(2), e210506.
[http://dx.doi.org/10.1530/EC-21-0506] [PMID: 35107083]
[8]
Varella, A.C.; Benseñor, I.M.; Janovsky, C.C.P.S.; Goulart, A.C.; Birck, M.G.; Santos, I.S.; Brunoni, A.R.; Lotufo, P.A. Thyroid‐stimulating hormone levels and incident depression: Results from the ELSA‐Brasil study. Clin. Endocrinol. (Oxf.), 2021, 94(5), 858-865.
[http://dx.doi.org/10.1111/cen.14407] [PMID: 33386609]
[9]
Bai, R.; Liu, S.; Zhao, Y.; Cheng, Y.; Li, S.; Lai, A.; Xie, Z.; Xu, X.; Lu, Z.; Xu, J. Depressive and anxiety disorders in systemic lupus erythematosus patients without major neuropsychiatric manifestations. J. Immunol. Res., 2016, 2016, 1-7.
[http://dx.doi.org/10.1155/2016/2829018] [PMID: 27747246]
[10]
Zheng, Y.; Zhao, J.; Phillips, M.; Liu, J.; Cai, M.; Sun, S.; Huang, M. Validity and reliability of the chinese hamilton depression rating scale. Br. J. Psychiatry, 1988, 152(5), 660-664.
[http://dx.doi.org/10.1192/bjp.152.5.660] [PMID: 3167442]
[11]
Wysokiński, A.; Kłoszewska, I. Level of thyroid-stimulating hormone (TSH) in patients with acute schizophrenia, unipolar depression or bipolar disorder. Neurochem. Res., 2014, 39(7), 1245-1253.
[http://dx.doi.org/10.1007/s11064-014-1305-3] [PMID: 24723220]
[12]
Brownlie, B.E.; Rae, A.M.; Walshe, J.W.; Wells, J.E. Psychoses associated with thyrotoxicosis - ‘thyrotoxic psychosis.’ A report of 18 cases, with statistical analysis of incidence. Eur. J. Endocrinol., 2000, 142(5), 438-444.
[http://dx.doi.org/10.1530/eje.0.1420438] [PMID: 10802519]
[13]
Dunlap, D.B. Thyroid Function Tests.Clinical Methods: The History, Physical, and Laboratory Examinations, 3rd ed.; Butterworths: Boston, 1990.
[14]
Duval, F.; Mokrani, M.C.; Erb, A.; Gonzalez Lopera, F.; Alexa, C.; Proudnikova, X.; Butucaru, I. Chronobiological hypothalamic–pituitary–thyroid axis status and antidepressant outcome in major depression. Psychoneuroendocrinology, 2015, 59, 71-80.
[http://dx.doi.org/10.1016/j.psyneuen.2015.05.005] [PMID: 26036452]
[15]
Thana, K.; Sikorskii, A.; Lehto, R.; Given, C.; Wyatt, G. Burden and psychological symptoms among caregivers of patients with solid tumor cancers. Eur. J. Oncol. Nurs., 2021, 52, 101979.
[http://dx.doi.org/10.1016/j.ejon.2021.101979] [PMID: 34058683]
[16]
Butow, P.N.; Best, M.C.; Davies, G.; Schlub, T.; Napier, C.E.; Bartley, N.; Ballinger, M.L.; Juraskova, I.; Meiser, B.; Goldstein, D.; Biesecker, B.; Thomas, D.M. Psychological impact of comprehensive tumor genomic profiling results for advanced cancer patients. Patient Educ. Couns., 2022, 105(7), 2206-2216.
[http://dx.doi.org/10.1016/j.pec.2022.01.011] [PMID: 35153126]
[17]
Castro-Figueroa, E.M.; Acevedo, K.I.; Peña-Vargas, C.I.; Torres-Blasco, N.; Flores, I.; Colón-Echevarria, C.B.; Maldonado, L.; Rodríguez, Z.; Aquino-Acevedo, A.N.; Jim, H.; Lazaro, M.I.; Armaiz-Peña, G.N. Depression, anxiety, and social environmental adversity as potential modulators of the immune tumor microenvironment in breast cancer patients. Med. Sci. (Basel), 2021, 9(2), 46.
[http://dx.doi.org/10.3390/medsci9020046] [PMID: 34205709]
[18]
Dong, H.J.; Larsson, B.; Dragioti, E.; Bernfort, L.; Levin, L.Å.; Gerdle, B. Factors associated with life satisfaction in older adults with chronic pain (PainS65+). J. Pain Res., 2020, 13, 475-489.
[http://dx.doi.org/10.2147/JPR.S234565] [PMID: 32184652]
[19]
Eslami-Amirabadi, M.; Sajjadi, S.A. The relation between thyroid dysregulation and impaired cognition/behaviour: An integrative review. J. Neuroendocrinol., 2021, 33(3), e12948.
[http://dx.doi.org/10.1111/jne.12948] [PMID: 33655583]
[20]
Chou, F.; Reome, E.; Davis, P. Impact on length of stay and readmission rates when converting oral to long-acting injectable antipsychotics in schizophrenia or schizoaffective disorder. Ment. Health Clin., 2016, 6(5), 254-259.
[http://dx.doi.org/10.9740/mhc.2016.09.254] [PMID: 29955479]
[21]
Sullivan, G.M.; Hatterer, J.A.; Herbert, J.; Chen, X.; Roose, S.P.; Attia, E.; Mann, J.J.; Marangell, L.B.; Goetz, R.R.; Gorman, J.M. Low levels of transthyretin in the CSF of depressed patients. Am. J. Psychiatry, 1999, 156(5), 710-715.
[http://dx.doi.org/10.1176/ajp.156.5.710] [PMID: 10327903]
[22]
Bauer, M.S.; Whybrow, P.C.; Winokur, A. Rapid cycling bipolar affective disorder. I. Association with grade I hypothyroidism. Arch. Gen. Psychiatry, 1990, 47(5), 427-432.
[http://dx.doi.org/10.1001/archpsyc.1990.01810170027005] [PMID: 2109970]
[23]
Pilhatsch, M.; Winter, C.; Nordström, K.; Vennström, B.; Bauer, M.; Juckel, G. Increased depressive behaviour in mice harboring the mutant thyroid hormone receptor alpha 1. Behav. Brain Res., 2010, 214(2), 187-192.
[http://dx.doi.org/10.1016/j.bbr.2010.05.016] [PMID: 20580649]
[24]
Hennemann, G.; Docter, R.; Friesema, E.C.H.; de Jong, M.; Krenning, E.P.; Visser, T.J. Plasma membrane transport of thyroid hormones and its role in thyroid hormone metabolism and bioavailability. Endocr. Rev., 2001, 22(4), 451-476.
[http://dx.doi.org/10.1210/edrv.22.4.0435] [PMID: 11493579]
[25]
Hu, G.; Yu, S.; Yuan, C.; Hong, W.; Wang, Z.; Zhang, R.; Wang, D.; Li, Z.; Yi, Z.; Fang, Y. Gene expression signatures differentiating major depressive disorder from subsyndromal symptomatic depression. Aging (Albany NY), 2021, 13(9), 13124-13137.
[http://dx.doi.org/10.18632/aging.202995] [PMID: 33971621]

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