Synthetic Protocols, Structural Activity Relationship, and Biological Activity of Piperazine and its Derivatives

Title:Synthetic Protocols, Structural Activity Relationship, and Biological Activity of Piperazine and its Derivatives

Volume: 20

Author(s): Md Faizan, Rajnish Kumar*, Avijit Mazumder, Salahuddin, Neelima Kukreti, Arvind Kumar and MVNL Chaitanya

Affiliation:

• Noida Institute of Engineering and Technology (Pharmacy Institute), Greater Noida-201310, India

Keywords: Piperazine, pharmacological activity, structural rigidity, bioavailability, affinity, specificity, structure-activity relationship.

Abstract: The versatile basic structure of piperazine allows for the development and production of newer bioactive molecules that can be used to treat a wide range of diseases. Piperazine derivatives are unique and can easily be modified for the desired pharmacological activity. The two opposing nitrogen atoms in a six-membered piperazine ring offer a large polar surface area, relative structural rigidity, and more acceptors and donors of hydrogen bonds. These properties frequently result in greater water solubility, oral bioavailability, and ADME characteristics, as well as improved target affinity and specificity. Various synthetic protocols have been reported for piperazine and its derivatives. In this review, we focused on recently published synthetic protocols for the synthesis of the piperazine and its derivatives. The structure-activity relationship concerning different biological activities of various piperazine-containing drugs was also highlighted to provide a good understanding to researchers for future research on piperazines.

Cite this article as:

Faizan Md, Kumar Rajnish*, Mazumder Avijit, Salahuddin , Kukreti Neelima, Kumar Arvind and Chaitanya MVNL, Synthetic Protocols, Structural Activity Relationship, and Biological Activity of Piperazine and its Derivatives, Medicinal Chemistry 2024; 20 () . https://dx.doi.org/10.2174/0115734064304396240415110015