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Current Protein & Peptide Science

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ISSN (Print): 1389-2037
ISSN (Online): 1875-5550

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Mini-Review Article

Molecular Players at the Sorting Stations of Malaria Parasite ‘Plasmodium falciparum’

Author(s): Jasweer Kaur, Prakash Chandra Mishra and Rachna Hora*

Volume 25, Issue 6, 2024

Published on: 23 February, 2024

Page: [427 - 437] Pages: 11

DOI: 10.2174/0113892037282522240130090156

Price: $65

Abstract

The apicomplexan pathogenic parasite ‘Plasmodium falciparum’ (Pf) is responsible for most of the malaria related mortality. It resides in and refurbishes the infected red blood cells (iRBCs) for its own survival and to suffice its metabolic needs. Remodeling of host erythrocytes involves alteration of physical and biochemical properties of the membrane and genesis of new parasite induced structures within the iRBCs. The generated structures include knobs and solute ion channels on the erythrocyte surface and specialized organelles i.e. Maurer’s clefts (MCs) in the iRBC cytosol. The above processes are mediated by exporting a large repertoire of proteins to the host cell, most of which are transported via MCs, the sorting stations in parasitized erythrocytes. Information about MC biogenesis and the molecules involved in maintaining MC architecture remains incompletely elucidated. Here, we have compiled a list of experimentally known MC resident proteins, several of which have roles in maintaining its architecture and function. Our short review covers available data on the domain organization, orthologues, topology and specific roles of these proteins. We highlight the current knowledge gaps in our understanding of MCs as crucial organelles involved in parasite biology and disease pathogenesis.

Keywords: Malaria, Plasmodium falciparum, Maurer’s cleft, exported proteins, protein trafficking, PEXEL.

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Graphical Abstract

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