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Current Protein & Peptide Science

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ISSN (Print): 1389-2037
ISSN (Online): 1875-5550

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Review Article

Recent Advances in Molecular Imprinting for Proteins on Magnetic Microspheres

Author(s): Jing Zhang, Shujie Yuan, Shujuan Beng, Wenhui Luo, Xiaoqun Wang, Lei Wang and Can Peng*

Volume 25, Issue 4, 2024

Published on: 04 January, 2024

Page: [286 - 306] Pages: 21

DOI: 10.2174/0113892037277894231208065403

Price: $65

Abstract

The separation of proteins in biological samples plays an essential role in the development of disease detection, drug discovery, and biological analysis. Protein imprinted polymers (PIPs) serve as a tool to capture target proteins specifically and selectively from complex media for separation purposes. Whereas conventional molecularly imprinted polymer is time-consuming in terms of incubation studies and solvent removal, magnetic particles are introduced using their magnetic properties for sedimentation and separation, resulting in saving extraction and centrifugation steps. Magnetic protein imprinted polymers (MPIPs), which combine molecularly imprinting materials with magnetic properties, have emerged as a new area of research hotspot. This review provides an overview of MPIPs for proteins, including synthesis, preparation strategies, and applications. Moreover, it also looks forward to the future directions for research in this emerging field.

Keywords: Protein imprinting, magnetic molecularly imprinted polymers, magnetic microspheres, selective separation, drug discovery, magnetic particles.

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