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Current Organic Chemistry

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ISSN (Print): 1385-2728
ISSN (Online): 1875-5348

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Review Article

Synthetic Update on Antimicrobial Potential of Novel Pyrazole Derivatives: A Review

Author(s): Sucheta Singh, Sumit Tahlan, Kuldeep Singh and Prabhakar Kumar Verma*

Volume 28, Issue 5, 2024

Published on: 08 March, 2024

Page: [325 - 345] Pages: 21

DOI: 10.2174/0113852728292094240216045039

Price: $65

Abstract

Heterocyclic compounds containing nitrogen and their derivatives have been a rich source of medicines. Pyrazole, a five-membered ring structure, offers a variety of functionalities as well as stereo-chemical complexity. Studies conducted over the past 10 years revealed that an increasing amount of research has been performed on different pyrazole derivatives and their physiological and pharmacological activities. The objective of these studies is to uncover the full potential of pyrazole derivatives by elucidating the many druglike properties and their link between the structure and mode of action. Here, we discuss different ways of synthesizing pyrazole derivatives. Due to recent advances in synthetic medicinal chemistry, this class of compounds can be readily developed and becomes a viable target for the discovery of novel drugs.

Keywords: Pyrazole derivatives, antibacterial, antifungal, antimicrobial, heterocyclic compounds, ring structure.

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