Nanoceria Anti-inflammatory and Antimicrobial Nanodrug: Cellular and Molecular Mechanism of Action

Title:Nanoceria Anti-inflammatory and Antimicrobial Nanodrug: Cellular and Molecular Mechanism of Action

Volume: 31

Author(s): Natália Cristina Gomes-da-Silva, Luana Barbosa Corrêa, Mariana Martínez González, Álefe Roger Silva França, Luciana Magalhães Rebelo Alencar, Elaine Cruz Rosas, Eduardo Ricci-Junior, Tawanny Kayonara Borges Aguiar, Pedro Filho Noronha Souza and Ralph Santos-Oliveira*

Affiliation:

• Brazilian Nuclear Energy Commission, Nuclear Engineering Institute, Laboratory of Nanoradiopharmacy and Synthesis of New Radiopharmaceuticals, Rio de Janeiro, 21941906, RJ, Brazil
• Rio de Janeiro State University, Laboratory of Radiopharmacy and Nanoradiopharmaceuticals, Rio de Janeiro, 23070200, RJ, Brazil.

Keywords: inflammation, antimicrobial resistance, nanodrugs, bacterial infection, nanotechnology

Abstract: Introduction: Nanoceria is a well-known nanomaterial with various properties, including antioxidant, proangiogenic, and therapeutic effects. Despite its potential, there are still aspects that require further exploration, particularly its anti-inflammatory and antimicrobial activities.

Method: The global demand for novel anti-inflammatory and antimicrobial drugs underscores the significance of understanding nanoceria in both contexts. In this study, we evaluated the effect of nanoceria on macrophage polarization to better understand its anti-inflammatory effects. Additionally, we investigated the mechanism of action of nanoceria against Cryptococcus neoformans (ATCC 32045), Candida parapsilosis (ATCC 22019), Candida krusei (ATCC 6258), and Candida albicans.

Result: The results demonstrated that nanoceria can polarize macrophages toward an anti-inflammatory profile, revealing the cellular mechanisms involved in the anti-inflammatory response. Concerning the antimicrobial effect, it was observed that nanoceria have a more pronounced impact on Candida parapsilosis, leading to the formation of pronounced pores on the surface of this species.

Conclusion: Finally, biochemical analysis revealed transitory alterations, mainly in liver enzymes. The data support the use of nanoceria as a potential anti-inflammatory and antimicrobial drug and elucidate some of the mechanisms involved, shedding light on the properties of this nanodrug.

Cite this article as:

Gomes-da-Silva Cristina Natália, Corrêa Barbosa Luana, González Martínez Mariana, Silva França Roger Álefe, Rebelo Alencar Magalhães Luciana, Rosas Cruz Elaine, Ricci-Junior Eduardo, Borges Aguiar Kayonara Tawanny, Noronha Souza Pedro Filho and Santos-Oliveira Ralph*, Nanoceria Anti-inflammatory and Antimicrobial Nanodrug: Cellular and Molecular Mechanism of Action, Current Medicinal Chemistry 2024; 31 () . https://dx.doi.org/10.2174/0109298673285605231229112525

DOI https://dx.doi.org/10.2174/0109298673285605231229112525	Print ISSN 0929-8673
Publisher Name Bentham Science Publisher	Online ISSN 1875-533X