Abstract
Every year about 7 million people die from of various types of cancer, making this disease responsible for 12.5% of deaths worldwide. Consequently, there is an overwhelming demand to develop new, more potent and effective, anticancer drugs. Natural products represent the most valuable source with inexhaustible reserves, in which the researchers work could identify novel active agents that may serve as the leads and scaffolds for transformation into desperately needed efficacious drugs. This paper is devoted to reviewing some of the most outstanding achievements in the application of natural products as models and precursors for anticancer agents published in the post 2000 literature. Particular emphasis is placed on the chemical modification of active principles isolated from natural products, in hope of obtaining the desirable derivatives for the treatment of different types of cancer, including pancreatic, gastric, breast, colon cancers and leukemia.
Keywords: Anticancer, natural products, pancreatic cancer, gastric cancer, breast cancer, colon cancer, leukemia
Mini-Reviews in Medicinal Chemistry
Title: Natural Products and their Analogues as Efficient Anticancer Drugs
Volume: 9 Issue: 5
Author(s): Sergiu Coseri
Affiliation:
Keywords: Anticancer, natural products, pancreatic cancer, gastric cancer, breast cancer, colon cancer, leukemia
Abstract: Every year about 7 million people die from of various types of cancer, making this disease responsible for 12.5% of deaths worldwide. Consequently, there is an overwhelming demand to develop new, more potent and effective, anticancer drugs. Natural products represent the most valuable source with inexhaustible reserves, in which the researchers work could identify novel active agents that may serve as the leads and scaffolds for transformation into desperately needed efficacious drugs. This paper is devoted to reviewing some of the most outstanding achievements in the application of natural products as models and precursors for anticancer agents published in the post 2000 literature. Particular emphasis is placed on the chemical modification of active principles isolated from natural products, in hope of obtaining the desirable derivatives for the treatment of different types of cancer, including pancreatic, gastric, breast, colon cancers and leukemia.
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Cite this article as:
Coseri Sergiu, Natural Products and their Analogues as Efficient Anticancer Drugs, Mini-Reviews in Medicinal Chemistry 2009; 9 (5) . https://dx.doi.org/10.2174/138955709788167592
DOI https://dx.doi.org/10.2174/138955709788167592 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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