Abstract
Activation-induced cell death (AICD) is an active process. T and B lymphocytes undergo AICD as an auto-regulatory mechanism for the body to remove unwanted activated cells after making appropriate use of them. Recent studies have shown that brain microglia and astrocytes also undergo apoptosis upon inflammatory activation. Caspase-11 has been demonstrated to play a central role in the apoptosis of both microglia and astrocytes following inflammatory activation; inflammatory stimuli induce neuroglial apoptosis through caspases-11, -1, and -3. Thus, inflammatory signals that activate neuroglia may also initiate internal death program, in which caspases play a crucial role. Caspases may be a target for the modulation of neuroglial AICD that has implications in neurodegenerative diseases.
Keywords: apoptosis, caspase, microglia, astrocyte, nitric oxide, inflammation, signal transduction, neurodegenerative diseases
Current Enzyme Inhibition
Title: Role of Caspases in Activation-Induced Cell Death of Neuroglia
Volume: 1 Issue: 1
Author(s): Kyoungho Suk
Affiliation:
Keywords: apoptosis, caspase, microglia, astrocyte, nitric oxide, inflammation, signal transduction, neurodegenerative diseases
Abstract: Activation-induced cell death (AICD) is an active process. T and B lymphocytes undergo AICD as an auto-regulatory mechanism for the body to remove unwanted activated cells after making appropriate use of them. Recent studies have shown that brain microglia and astrocytes also undergo apoptosis upon inflammatory activation. Caspase-11 has been demonstrated to play a central role in the apoptosis of both microglia and astrocytes following inflammatory activation; inflammatory stimuli induce neuroglial apoptosis through caspases-11, -1, and -3. Thus, inflammatory signals that activate neuroglia may also initiate internal death program, in which caspases play a crucial role. Caspases may be a target for the modulation of neuroglial AICD that has implications in neurodegenerative diseases.
Export Options
About this article
Cite this article as:
Suk Kyoungho, Role of Caspases in Activation-Induced Cell Death of Neuroglia, Current Enzyme Inhibition 2005; 1 (1) . https://dx.doi.org/10.2174/1573408052952757
DOI https://dx.doi.org/10.2174/1573408052952757 |
Print ISSN 1573-4080 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6662 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
LPS-induced Murine Neuroinflammation Model: Main Features and Suitability for Pre-clinical Assessment of Nutraceuticals
Current Neuropharmacology Mechanisms of Mononuclear Phagocyte Recruitment in Alzheimers Disease
CNS & Neurological Disorders - Drug Targets From the Oxygen to the Organ Protection: Erythropoietin as Protagonist in Internal Medicine
Cardiovascular & Hematological Agents in Medicinal Chemistry Basic Approaches in Therapy of Multiple Sclerosis (MS) and Related Diseases: Current Achievement and Prospective
Central Nervous System Agents in Medicinal Chemistry Vaccine Development for Alzheimers Disease
Current Pharmaceutical Design Brain Arrhythmias Induced by Amyloid Beta and Inflammation: Involvement in Alzheimer’s Disease and Other Inflammation-related Pathologies
Current Alzheimer Research Impact of MCP -1 in Atherosclerosis
Current Pharmaceutical Design Recognition and Function of HumanγδT Cells: Application for Tumor Immunotherapy
Current Immunology Reviews (Discontinued) Nanotechnology in Therapeutics – Current Technologies and Applications
Current Nanoscience Advances in Fish Cytokine Biology Give Clues to the Evolution of a Complex Network
Current Pharmaceutical Design Microbiota Regulation of Inflammatory Bowel Disease
Inflammation & Allergy - Drug Targets (Discontinued) From the Molecular Mechanism to Pre-clinical Results: Anti-epileptic Effects of Fingolimod
Current Neuropharmacology Editorial: [Hot Topic: Central Nervous System Drugs in the Treatment of Neurological Disorders]
Central Nervous System Agents in Medicinal Chemistry A Closer Look to Polyesters: Properties, Synthesis, Characterization, and Particle Drug Delivery Applications
Nanoscience & Nanotechnology-Asia The Discovery of CDP323, a Potent Alpha4 Integrin Antagonist
Current Immunology Reviews (Discontinued) In Vivo Imaging of the Diseased Nervous System: An Update
Current Pharmaceutical Design Citicoline and Retinal Ganglion Cells: Effects on Morphology and Function
Current Neuropharmacology Clients and Oncogenic Roles of Molecular Chaperone gp96/grp94
Current Topics in Medicinal Chemistry Critical Questions for Preclinical Trials on Safety and Efficacy of Vascular Endothelial Growth Factor-Based Therapeutic Angiogenesis for Ischemic Stroke
CNS & Neurological Disorders - Drug Targets Integrin α4β7 Antagonists: Activities, Mechanisms of Action and Therapeutic Prospects
Current Immunology Reviews (Discontinued)