Abstract
Increasing evidence suggests that stress signaling pathways emanating from the endoplasmic reticulum (ER) are important to the pathogenesis of both type 1 and type 2 diabetes. Recent observations indicate that ER stress signaling participates in maintaining the ER homeostasis of pancreatic β-cells. Either a high level of ER stress or defective ER stress signaling in β-cells may cause an imbalance in ER homeostasis and lead to β-cell apoptosis and autoimmune response. In addition, it has been suggested that ER stress attributes to insulin resistance in patients with type 2 diabetes. It is necessary to study the relationship between ER stress and diabetes in order to develop new therapeutic approaches to diabetes based on drugs that block the ER stress-mediated cell-death pathway and insulin resistance.
Keywords: PKR-like ER kinase (PERK), Wolcott-Rallison Syndrome, EIF2AK3 gene, pro-apoptotic factors, JNK-inhibitory peptide
Current Molecular Medicine
Title: Endoplasmic Reticulum Stress-Induced Apoptosis and Autoimmunity in Diabetes
Volume: 6 Issue: 1
Author(s): Kathryn L. Lipson, Sonya G. Fonseca and Fumihiko Urano
Affiliation:
Keywords: PKR-like ER kinase (PERK), Wolcott-Rallison Syndrome, EIF2AK3 gene, pro-apoptotic factors, JNK-inhibitory peptide
Abstract: Increasing evidence suggests that stress signaling pathways emanating from the endoplasmic reticulum (ER) are important to the pathogenesis of both type 1 and type 2 diabetes. Recent observations indicate that ER stress signaling participates in maintaining the ER homeostasis of pancreatic β-cells. Either a high level of ER stress or defective ER stress signaling in β-cells may cause an imbalance in ER homeostasis and lead to β-cell apoptosis and autoimmune response. In addition, it has been suggested that ER stress attributes to insulin resistance in patients with type 2 diabetes. It is necessary to study the relationship between ER stress and diabetes in order to develop new therapeutic approaches to diabetes based on drugs that block the ER stress-mediated cell-death pathway and insulin resistance.
Export Options
About this article
Cite this article as:
Lipson L. Kathryn, Fonseca G. Sonya and Urano Fumihiko, Endoplasmic Reticulum Stress-Induced Apoptosis and Autoimmunity in Diabetes, Current Molecular Medicine 2006; 6 (1) . https://dx.doi.org/10.2174/156652406775574613
DOI https://dx.doi.org/10.2174/156652406775574613 |
Print ISSN 1566-5240 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5666 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Synthesis and Biological Evaluation of the Salicylamide and Salicylic Acid Derivatives as Anti-Estrogen Agents
Medicinal Chemistry Editorial (Thematic Issue: Linkage of Neurodegenerative Disorders with Other Health Issues – Volume II)
CNS & Neurological Disorders - Drug Targets subject Index To Volume 2
Current Topics in Medicinal Chemistry Aqueous Extract of Anabasis aretioides Ameliorates Streptozotocininduced Diabetes Mellitus in Rats
The Natural Products Journal Chitosan and Its Use in Design of Insulin Delivery System
Recent Patents on Drug Delivery & Formulation How Immune-inflammatory Processes Link CNS and Psychiatric Disorders: Classification and Treatment Implications
CNS & Neurological Disorders - Drug Targets Electrochemical Detection and Sensing of Reactive Oxygen Species
Current Organic Chemistry Azole Antimycotics - A Highway to New Drugs or a Dead End?
Current Medicinal Chemistry Bacteriophage - A Common Divergent Therapeutic Approach for Alzheimer's Disease and Type II Diabetes Mellitus
CNS & Neurological Disorders - Drug Targets Traumatic Brain Injury as a Risk Factor for Alzheimer’s Disease: Is Inflammatory Signaling a Key Player?
Current Alzheimer Research Impact of Red Wine Consumption on Cardiovascular Health
Current Medicinal Chemistry Clinical Proteomics in Application to Predictive Diagnostics and Personalized Treatment of Diabetic Patients
Current Proteomics Neonatal Withdrawal Reactions Following Late in Utero Exposure to Antidepressant Medications
Current Women`s Health Reviews Electroporation Gene Therapy: New Developments In Vivo and In Vitro
Current Gene Therapy Conduction Disorders: The Value of Surface ECG
Current Cardiology Reviews Clinical Trials for Acute Kidney Injury: Design Challenges and Possible Solutions
Current Drug Targets Dysregulated Pathway Identification of Alzheimer's Disease Based on Internal Correlation Analysis of Genes and Pathways
Combinatorial Chemistry & High Throughput Screening Role of Thrombin Activatable Fibrinolysis Inhibitor in Endocrine and Cardiovascular Disorders: An Update
Recent Patents on Endocrine, Metabolic & Immune Drug Discovery Interleukin -17 Serum Levels and Polymorphisms in Acute Kidney Injury Patients
Endocrine, Metabolic & Immune Disorders - Drug Targets Ethosomes and Transfersomes: Principles, Perspectives and Practices
Current Drug Delivery