Abstract
Baculovirus is an effective vector for gene delivery into various mammalian cells, including chondrocytes and mesenchymal stem cells, and has been employed for diverse applications. By gene delivery and expression of the growth factor, recombinant baculovirus has been shown to modulate the differentiation state of the cells and stimulates the production of extracellular matrix and tissue formation, hence repairing the damaged cartilage and bone in vivo. This article reviews the studies pertaining to the applications of baculovirus-mediated gene delivery in cartilage and bone tissue engineering and discusses recent progress, future applications and potential hurdles.
Keywords: Baculovirus, bone, cartilage, gene therapy, tissue engineering
Current Gene Therapy
Title: Baculovirus as a Gene Delivery Vector for Cartilage and Bone Tissue Engineering
Volume: 10 Issue: 3
Author(s): Chin-Yu Lin, Chia-Hsin Lu, Wen-Yi Luo, Yu-Han Chang, Li-Yu Sung, Hsin-Yi Chiu and Yu-Chen Hu
Affiliation:
Keywords: Baculovirus, bone, cartilage, gene therapy, tissue engineering
Abstract: Baculovirus is an effective vector for gene delivery into various mammalian cells, including chondrocytes and mesenchymal stem cells, and has been employed for diverse applications. By gene delivery and expression of the growth factor, recombinant baculovirus has been shown to modulate the differentiation state of the cells and stimulates the production of extracellular matrix and tissue formation, hence repairing the damaged cartilage and bone in vivo. This article reviews the studies pertaining to the applications of baculovirus-mediated gene delivery in cartilage and bone tissue engineering and discusses recent progress, future applications and potential hurdles.
Export Options
About this article
Cite this article as:
Lin Chin-Yu, Lu Chia-Hsin, Luo Wen-Yi, Chang Yu-Han, Sung Li-Yu, Chiu Hsin-Yi and Hu Yu-Chen, Baculovirus as a Gene Delivery Vector for Cartilage and Bone Tissue Engineering, Current Gene Therapy 2010; 10 (3) . https://dx.doi.org/10.2174/156652310791321242
DOI https://dx.doi.org/10.2174/156652310791321242 |
Print ISSN 1566-5232 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5631 |
Call for Papers in Thematic Issues
Programmed Cell Death Genes in Oncology: Pioneering Therapeutic and Diagnostic Frontiers (BMS-CGT-2024-HT-45)
Programmed Cell Death (PCD) is recognized as a pivotal biological mechanism with far-reaching effects in the realm of cancer therapy. This complex process encompasses a variety of cell death modalities, including apoptosis, autophagic cell death, pyroptosis, and ferroptosis, each of which contributes to the intricate landscape of cancer development and ...read more
Related Journals
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Potential Replication of Induced Pluripotent Stem Cells for Craniofacial Reconstruction
Current Stem Cell Research & Therapy Apis mellifera Proteomics: Where Will the Future Bee?
Current Proteomics Non-viral Delivery Systems for the Application in p53 Cancer Gene Therapy
Current Medicinal Chemistry Management of the Low Cardiac Output Syndrome Following Surgery for Congenital Heart Disease
Current Cardiology Reviews The Human L1 Element: A Potential Biomarker in Cancer Prognosis, Current Status and Future Directions
Current Molecular Medicine Mechanical Circulatory Support of the Critically Ill Child Awaiting Heart Transplantation
Current Cardiology Reviews Cell Therapy Using Induced Pluripotent Stem Cells or Somatic Stem Cells: This is the Question
Current Stem Cell Research & Therapy Scaffolds for Bone Regeneration: State of the Art
Current Pharmaceutical Design Stem Cells in Skeletal Tissue Engineering: Technologies and Models
Current Stem Cell Research & Therapy Self-assembly of Functional Molecular Shuttles Based on Organic Conjugated Molecules
Current Organic Chemistry Cardiovascular Complications in Patients with Klinefelter’s Syndrome
Current Pharmaceutical Design Remote Control of Pulmonary Blood Flow
Current Cardiology Reviews Robotic Assisted Surgery in Gynecology: Current Insights and Future Perspectives
Recent Patents on Biotechnology Complications of the Chest Wall and the Respiratory System After Surgery and Functional Performance
Current Respiratory Medicine Reviews Tetralogy of Fallot and Hypoplastic Left Heart Syndrome – Complex Clinical Phenotypes Meet Complex Genetic Networks
Current Genomics RNA-Mediated Therapeutics: From Gene Inactivation to Clinical Application
Current Topics in Medicinal Chemistry Therapeutic Potential of N-Acetylcysteine for Wound Healing, Acute Bronchiolitis, and Congenital Heart Defects
Current Drug Metabolism Cardiovascular Diseases in Pregnancy - A Brief Overview
Current Cardiology Reviews Conserved Molecular Players for Axon Guidance and Angiogenesis
Current Protein & Peptide Science Normal Ventricular Functional Reference Parameters on Magnetic Resonance Imaging in Healthy Children
Current Medical Imaging