Abstract
Imidazoles are one of the most promising and vigorously pursued areas of contemporary antifungal chemotherapy depicting broad spectrum and potent activity. They have relatively simple molecular nucleus, which is amenable to many structural modifications. These agents have several favorable properties such as excellent bioavailability, good tissue penetrability and permeability and a relatively low incidence of adverse and toxic effects. They have been found effective in the treatment of various infectious diseases. This paper is an attempt to review the therapeutic potential of imidazoles as antifungal with an updated account on their development.
Keywords: Antifungal agent, Antimycotic agent, Imidazole, Structure-Activity Relationship study.
Mini-Reviews in Medicinal Chemistry
Title:Imidazoles as Potential Antifungal Agents: A Review
Volume: 13 Issue: 11
Author(s): Nidhi Rani, Ajay Sharma, Girish Kumar Gupta and Randhir Singh
Affiliation:
Keywords: Antifungal agent, Antimycotic agent, Imidazole, Structure-Activity Relationship study.
Abstract: Imidazoles are one of the most promising and vigorously pursued areas of contemporary antifungal chemotherapy depicting broad spectrum and potent activity. They have relatively simple molecular nucleus, which is amenable to many structural modifications. These agents have several favorable properties such as excellent bioavailability, good tissue penetrability and permeability and a relatively low incidence of adverse and toxic effects. They have been found effective in the treatment of various infectious diseases. This paper is an attempt to review the therapeutic potential of imidazoles as antifungal with an updated account on their development.
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Cite this article as:
Rani Nidhi, Sharma Ajay, Gupta Kumar Girish and Singh Randhir, Imidazoles as Potential Antifungal Agents: A Review, Mini-Reviews in Medicinal Chemistry 2013; 13 (11) . https://dx.doi.org/10.2174/13895575113139990069
DOI https://dx.doi.org/10.2174/13895575113139990069 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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