Abstract
Apoptosis of bronchial epithelial cells and the phagocytic clearance of these cells by alveolar macrophages (a process termed efferocytosis) are integral processes leading to repair of airway epithelial injury. Efferocytosis allows for the removal of apoptotic material with minimal inflammation and prevents the development of secondary necrosis and ongoing inflammation. Defective efferocytosis and the increased presence of apoptotic cells have been identified in the airways of subjects with chronic obstructive pulmonary disease (COPD). There are three major potential causes for this accumulation of apoptotic cells: (i) increased apoptosis per se as a result of an increase in apoptotic mediators, (ii) defects in the recognition of apoptotic cells by AM and (iii) failure to clear the unwanted cells by the process of efferocytosis. The implications of these processes in COPD and novel treatment strategies aimed at improving clearance of apoptotic cells form the focus of the present review.
Keywords: Alveolar macrophage, apoptosis, collectin, COPD, efferocytosis, phagocytosis, tobacco smoke, protease, granzyme, perforin, oxidative stress, Mannose receptor
Current Drug Targets
Title: Airway Clearance of Apoptotic Cells in COPD
Volume: 12 Issue: 4
Author(s): Violet R.S. Mukaro and Sandra Hodge
Affiliation:
Keywords: Alveolar macrophage, apoptosis, collectin, COPD, efferocytosis, phagocytosis, tobacco smoke, protease, granzyme, perforin, oxidative stress, Mannose receptor
Abstract: Apoptosis of bronchial epithelial cells and the phagocytic clearance of these cells by alveolar macrophages (a process termed efferocytosis) are integral processes leading to repair of airway epithelial injury. Efferocytosis allows for the removal of apoptotic material with minimal inflammation and prevents the development of secondary necrosis and ongoing inflammation. Defective efferocytosis and the increased presence of apoptotic cells have been identified in the airways of subjects with chronic obstructive pulmonary disease (COPD). There are three major potential causes for this accumulation of apoptotic cells: (i) increased apoptosis per se as a result of an increase in apoptotic mediators, (ii) defects in the recognition of apoptotic cells by AM and (iii) failure to clear the unwanted cells by the process of efferocytosis. The implications of these processes in COPD and novel treatment strategies aimed at improving clearance of apoptotic cells form the focus of the present review.
Export Options
About this article
Cite this article as:
R.S. Mukaro Violet and Hodge Sandra, Airway Clearance of Apoptotic Cells in COPD, Current Drug Targets 2011; 12 (4) . https://dx.doi.org/10.2174/138945011794751609
DOI https://dx.doi.org/10.2174/138945011794751609 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
Call for Papers in Thematic Issues
New drug therapy for eye diseases
Eyesight is one of the most critical senses, accounting for over 80% of our perceptions. Our quality of life might be significantly affected by eye disease, including glaucoma, diabetic retinopathy, dry eye, etc. Although the development of microinvasive ocular surgery reduces surgical complications and improves overall outcomes, medication therapy is ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Different Lifestyles in Young Women From Urban and Rural Areas May Explain Different Cardiovascular Risk
Vascular Disease Prevention (Discontinued) Porphyromonas Gingivalis Antigenic Determinants - Potential Targets for the Vaccine Development against Periodontitis
Infectious Disorders - Drug Targets Aptamers: Selection, Modification and Application to Nervous System Diseases
Current Medicinal Chemistry High Altitude Hypoxia
Current Proteomics Neurotransplantation Therapy and Cerebellar Reserve
CNS & Neurological Disorders - Drug Targets Diagnostic and Therapeutic Nanoparticles in Cardiovascular Diseases
Current Pharmaceutical Design Clinical Grade Stem Cell Culture
Recent Patents on Regenerative Medicine In vitro Study of Furazano[3,4-b]quinoxaline 1-Oxides as Potential ΝΟ Releasing Agents
Letters in Drug Design & Discovery Caldesmon as a Therapeutic Target for Proliferative Vascular Diseases
Mini-Reviews in Medicinal Chemistry Neuroprotective Effects of Estrogens: Cross-Talk Between Estrogen and Intracellular Insulin Signalling
Infectious Disorders - Drug Targets Diagnosis and Treatment of Dyslipidaemias in Athletes
Current Vascular Pharmacology Repeated Restraint and Nerve Growth Factor Administration in Male and Female Mice: Effect on Sympathetic and Cardiovascular Mediators of the Stress Response
Current Neurovascular Research The Role of Statins in the Activation of Heme Oxygenase-1 in Cardiovascular Diseases
Current Drug Targets Heart Failure in Acute Ischemic Stroke
Current Cardiology Reviews A Variant in the Endoglin Gene is Associated with the Development of Sporadic Intracranial Aneurysms
Current Neurovascular Research Should We be Concerned About the Inflammatory Response to Endovascular Procedures?
Current Vascular Pharmacology Inflammation: A Link Between Hypertension and Atherosclerosis
Current Hypertension Reviews Blood Coagulation and the Risk of Atherothrombosis
Current Genomics Thiazolidinediones and Type 2 Diabetes: From Cellular Targets to Cardiovascular Benefit
Current Drug Targets Cerebrovascular Amyloidosis and Dementia
Current Medicinal Chemistry - Immunology, Endocrine & Metabolic Agents