Abstract
Derivatization of cyclodextrins (CDs) demands creative chemistry and sound analytical characterization. Structural characterization of solid cyclodextrins and their inclusion compounds places strong reliance on X-ray diffraction (XRD) analysis. In this review, following introductory remarks on the role of single crystal XRD and the under-utilized power of powder XRD, a survey of crystal structures of pure CD hosts and CD inclusion compounds carried out during the last six years is presented. The entries range from simple alkylated derivatives to elegant multi-substituted target CD molecules, with and without included guests. For the majority of the entries described, the main structural features gleaned by XRD methods are outlined and their relevance to applications is highlighted.
Keywords: Crystal packing, derivatized cyclodextrins, host conformation, host design, isostructurality, powder X-ray diffraction, single crystal X-ray diffraction, supramolecular structures
Current Organic Chemistry
Title: Structural Aspects of Crystalline Derivatized Cyclodextrins and Their Inclusion Complexes
Volume: 15 Issue: 6
Author(s): Mino R. Caira
Affiliation:
Keywords: Crystal packing, derivatized cyclodextrins, host conformation, host design, isostructurality, powder X-ray diffraction, single crystal X-ray diffraction, supramolecular structures
Abstract: Derivatization of cyclodextrins (CDs) demands creative chemistry and sound analytical characterization. Structural characterization of solid cyclodextrins and their inclusion compounds places strong reliance on X-ray diffraction (XRD) analysis. In this review, following introductory remarks on the role of single crystal XRD and the under-utilized power of powder XRD, a survey of crystal structures of pure CD hosts and CD inclusion compounds carried out during the last six years is presented. The entries range from simple alkylated derivatives to elegant multi-substituted target CD molecules, with and without included guests. For the majority of the entries described, the main structural features gleaned by XRD methods are outlined and their relevance to applications is highlighted.
Export Options
About this article
Cite this article as:
R. Caira Mino, Structural Aspects of Crystalline Derivatized Cyclodextrins and Their Inclusion Complexes, Current Organic Chemistry 2011; 15 (6) . https://dx.doi.org/10.2174/138527211794518862
DOI https://dx.doi.org/10.2174/138527211794518862 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
Call for Papers in Thematic Issues
Advances of Heterocyclic Chemistry with Pesticide Activity
Global food safety and security will continue to be a global concern for the next 50 years and beyond. Plant diseases have had a significant impact on food safety and security throughout the entire food chain, from primary production to consumption. While conventional chemical pesticides have been traditionally used for ...read more
Carbohydrates conversion in biofuels and bioproducts
Biomass pretreatment, hydrolysis, and saccharification of carbohydrates, and sugars bioconversion in biofuels and bioproducts within a biorefinery framework. Carbohydrates derived from woody biomass, agricultural wastes, algae, sewage sludge, or any other lignocellulosic feedstock are included in this issue. Simulation, techno-economic analysis, and life cycle analysis of a biorefinery process are ...read more
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
Chemistry and Biology of Carbohydrates
Carbohydrates are one of the most abundant natural products and are considered to be extremely important biomolecules for their ever-increasing impact on chemistry and biology. Their role in several important biological processes, notably energy storage, transport, modulation of protein function, intercellular adhesion, malignant transformation, signal transduction, viral, and bacterial cell ...read more
Related Journals
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Derivatives of Procaspase-Activating Compound 1 (PAC-1) and their Anticancer Activities
Current Medicinal Chemistry Lentiviral Vectors: A Versatile Tool to Fight Cancer
Current Molecular Medicine Phage Display Applications for Molecular Imaging
Current Pharmaceutical Biotechnology Somatostatin, Somatostatin Analogs and Somatostatin Receptor Dynamics in the Biology of Cancer Progression
Current Molecular Medicine Focal Adhesion Kinase as a Cancer Therapy Target
Anti-Cancer Agents in Medicinal Chemistry Effects of Iron Chelation in Osteosarcoma
Current Cancer Drug Targets How Do Microtubule-Targeted Drugs Work? An Overview
Current Cancer Drug Targets Oxidovanadium(IV) Complex Disrupts Mitochondrial Membrane Potential and Induces Apoptosis in Pancreatic Cancer Cells
Anti-Cancer Agents in Medicinal Chemistry Polyoxometalates in Biomedicine: Update and Overview
Current Medicinal Chemistry Modular Protein Engineering in Emerging Cancer Therapies
Current Pharmaceutical Design SUMOylation Modulates CFTR Biogenesis: Is the Pathway Druggable?
Current Drug Targets Hyaluronan/Hyaladherins - a Promising Axis for Targeted Drug Delivery in Cancer
Current Drug Delivery Nanotechnology Enabled Drug Delivery Systems for Bone and Cartilage Regeneration
Recent Patents on Biomedical Engineering (Discontinued) The Genetic Landscapes of Inflammation-Driven Gastrointestinal Tract Cancers
Current Pharmaceutical Design PEGylated Peptide-Based Imaging Agents for Targeted Molecular Imaging
Current Protein & Peptide Science Recent Developments in the Field of Tumor-Inhibiting Metal Complexes
Current Pharmaceutical Design Immunomodulation and Anti-inflammatory Roles of Polyphenols as Anticancer Agents
Anti-Cancer Agents in Medicinal Chemistry Evaluation of the Anticancer Activities of the Plant Alkaloids Sanguinarine and Chelerythrine in Human Breast Adenocarcinoma Cells
Anti-Cancer Agents in Medicinal Chemistry Development and Uses of Offline and Web-Searchable Metabolism Databases - The Case of Benzo[a]pyrene
Current Drug Metabolism A Rationale for the Use of Proton Pump Inhibitors as Antineoplastic Agents
Current Pharmaceutical Design