Abstract
Background: Despite the significant developments made in the field of diagnosis and treatment modalities of cancer during the last two decades, it still remains one of the most life threatening diseases killing 8.2 million people annually across the globe. It has been well-established that development of chemoresistance in cancer cells is the major cause of failure of chemotherapeutic agents in clinic. Most of the chemotherapeutic agents currently being used activate NF-κB and NF-κB regulated gene products in cancer cells and induce drug resistance. Increasing lines of evidences suggest that NF-κB blockers have high potential in decreasing drug resistance and sensitize cancer cells to chemotherapeutic agents.
Methods: A through literature search was carried out in pubmed to identify natural NF-κB inhibitors that possess high potential in sensitizing cancer cells.
Results: Our literature search retrived a number of NF-κB inhibitors that have been identified during the last several years. Notably, the inhibitors obtained from Mother Nature such as curcumin, tocotrienol, resveratrol, garcinol etc. are found to be highly safe, efficacious and inexpensive. Many preclinical and clinical studies have revealed that these agents can block the activation of NF-κB in cancer cells to overcome drug resistance and make them sensitive to chemotherapeutic agents.
Conclusion: Both basic and clinical research revealed that constitutive activation of NF-κB is the prime reason for inducing drug resistance in cancer cells. This comprehensive review scientifically evaluates the chemosensitizing potential of these natural agents which serve as potent NF-κB blockers, based on evidence based literature.
Keywords: Cancer, chemoresistance, NF-κB, chemosensitization, natural products.
Current Pharmaceutical Design
Title:NF-κB Blockers Gifted by Mother Nature: Prospectives in Cancer Cell Chemosensitization
Volume: 22 Issue: 27
Author(s): Javadi Monisha, Ganesan Padmavathi, Nand Kishor Roy, Anindita Deka, Devivasha Bordoloi, Anand Anip and Ajaikumar B. Kunnumakkara
Affiliation:
Keywords: Cancer, chemoresistance, NF-κB, chemosensitization, natural products.
Abstract: Background: Despite the significant developments made in the field of diagnosis and treatment modalities of cancer during the last two decades, it still remains one of the most life threatening diseases killing 8.2 million people annually across the globe. It has been well-established that development of chemoresistance in cancer cells is the major cause of failure of chemotherapeutic agents in clinic. Most of the chemotherapeutic agents currently being used activate NF-κB and NF-κB regulated gene products in cancer cells and induce drug resistance. Increasing lines of evidences suggest that NF-κB blockers have high potential in decreasing drug resistance and sensitize cancer cells to chemotherapeutic agents.
Methods: A through literature search was carried out in pubmed to identify natural NF-κB inhibitors that possess high potential in sensitizing cancer cells.
Results: Our literature search retrived a number of NF-κB inhibitors that have been identified during the last several years. Notably, the inhibitors obtained from Mother Nature such as curcumin, tocotrienol, resveratrol, garcinol etc. are found to be highly safe, efficacious and inexpensive. Many preclinical and clinical studies have revealed that these agents can block the activation of NF-κB in cancer cells to overcome drug resistance and make them sensitive to chemotherapeutic agents.
Conclusion: Both basic and clinical research revealed that constitutive activation of NF-κB is the prime reason for inducing drug resistance in cancer cells. This comprehensive review scientifically evaluates the chemosensitizing potential of these natural agents which serve as potent NF-κB blockers, based on evidence based literature.
Export Options
About this article
Cite this article as:
Monisha Javadi, Padmavathi Ganesan, Roy Kishor Nand, Deka Anindita, Bordoloi Devivasha, Anip Anand and Kunnumakkara B. Ajaikumar, NF-κB Blockers Gifted by Mother Nature: Prospectives in Cancer Cell Chemosensitization, Current Pharmaceutical Design 2016; 22 (27) . https://dx.doi.org/10.2174/1381612822666160609110231
DOI https://dx.doi.org/10.2174/1381612822666160609110231 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
Call for Papers in Thematic Issues
"Tuberculosis Prevention, Diagnosis and Drug Discovery"
The Nobel Prize-winning discoveries of Mycobacterium tuberculosis and streptomycin have enabled an appropriate diagnosis and an effective treatment of tuberculosis (TB). Since then, many newer diagnosis methods and drugs have been saving millions of lives. Despite advances in the past, TB is still a leading cause of infectious disease mortality ...read more
?Revolutionizing Cancer Treatment: Nano-Therapeutics Targeting Tumor Microenvironment?
This thematic issue explores the forefront of cancer treatment, centering on the groundbreaking potential of nano-therapeutics meticulously designed to target the tumor microenvironment. At its core, the issue aims to unravel the latest advancements in nanotechnology, showcasing innovative materials, formulations, and delivery systems that hold promise for redefining cancer therapeutics. ...read more
Current Pharmaceutical challenges in the treatment and diagnosis of neurological dysfunctions
Neurological dysfunctions (MND, ALS, MS, PD, AD, HD, ALS, Autism, OCD etc..) present significant challenges in both diagnosis and treatment, often necessitating innovative approaches and therapeutic interventions. This thematic issue aims to explore the current pharmaceutical landscape surrounding neurological disorders, shedding light on the challenges faced by researchers, clinicians, and ...read more
Emerging and re-emerging diseases
Faced with a possible endemic situation of COVID-19, the world has experienced two important phenomena, the emergence of new infectious diseases and/or the resurgence of previously eradicated infectious diseases. Furthermore, the geographic distribution of such diseases has also undergone changes. This context, in turn, may have a strong relationship with ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Radiosensitization of Prostate Cancer by Soy Isoflavones
Current Cancer Drug Targets Study on Adsorption and Sustained Release of Eucommia ulmoides Oliv. Leaf Extracts on Activated Carbon
Current Drug Delivery The Therapeutic Potential of Small Activating RNAs for Colorectal Carcinoma
Current Gene Therapy Role of Active Drug Transporters in Refractory Multiple Myeloma
Current Topics in Medicinal Chemistry Purification and Characterization of a Novel Peroxidase from Bitter Gourd (Momordica charantia)
Protein & Peptide Letters Biomedical Applications of Gold Nanoparticles
Current Topics in Medicinal Chemistry Dehydroepiandrosterone and Its Derivatives: Potentially Novel Anti-Proliferative and Chemopreventive Agents
Current Pharmaceutical Design CASC15: A Tumor-Associated Long Non-Coding RNA
Current Pharmaceutical Design Aminolevulinic Acid Derivatives and Liposome Delivery as Strategies for Improving 5-Aminolevulinic Acid- Mediated Photodynamic Therapy
Current Medicinal Chemistry Cervical Cancer Diagnosis: Insights into Biochemical Biomarkers and Imaging Techniques
Combinatorial Chemistry & High Throughput Screening ABC Transporters in Multidrug Resistance and Pharmacokinetics, and Strategies for Drug Development
Current Pharmaceutical Design Inflammation and Pancreatic Cancer: Recent Development with Focusing on Potential New Drug Targets
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry The Contractile Properties of Airway Smooth Muscle: How their Defects can be Linked to Asthmatic Airway Hyperresponsiveness?
Current Respiratory Medicine Reviews Differentiation-Inducing Therapy for Solid Tumors
Current Pharmaceutical Design Histone Deacetylase Inhibitors and Anticancer Therapy
Current Medicinal Chemistry - Anti-Cancer Agents Sentinel Lymph Node Mapping in Early Stage Endometrial Cancer Patients in Low-Resource Settings
Current Women`s Health Reviews Future Prospect of RNA Interference for Cancer Therapies
Current Drug Targets Structures Required of Polyphenols for Inhibiting Advanced Glycation end Products Formation
Current Drug Metabolism Gold Nanoparticles - Synthesis and Applications in Cancer Management
Recent Patents on Materials Science Rhenium-188 and Copper-67 Radiopharmaceuticals for the Treatment of Bladder Cancer
Mini-Reviews in Medicinal Chemistry