Abstract
There is now convincing experimental evidence documenting acute and transient actions of steroid hormones in the vasculature. Steroids can rapidly activate signalling cascades within endothelial and smooth muscle cells that seem to bypass the classical, genomic receptor. Activation of these signalling cascades, involving alterations in intracellular Ca2 and MAPK activity, leads to changes in membrane potential and/or Ca2 fluxes through L-type channels. In addition to stimulating NO production acutely in endothelial cells, chronic exposure to 17b-oestradiol may activate expression of eNOS via a genomic receptor(s).
Keywords: Rapid non genomic vasodilator actions, oestrogens, sex steroids, intracellular Ca2, MAPK activity, oestradiol, non genomic actions
Current Medicinal Chemistry
Title: Rapid Non-genomic Vasodilator Actions of Oestrogens and Sex Steroids
Volume: 7 Issue: 5
Author(s): Dietrich O. Ruehlmann and Giovanni E. Mann
Affiliation:
Keywords: Rapid non genomic vasodilator actions, oestrogens, sex steroids, intracellular Ca2, MAPK activity, oestradiol, non genomic actions
Abstract: There is now convincing experimental evidence documenting acute and transient actions of steroid hormones in the vasculature. Steroids can rapidly activate signalling cascades within endothelial and smooth muscle cells that seem to bypass the classical, genomic receptor. Activation of these signalling cascades, involving alterations in intracellular Ca2 and MAPK activity, leads to changes in membrane potential and/or Ca2 fluxes through L-type channels. In addition to stimulating NO production acutely in endothelial cells, chronic exposure to 17b-oestradiol may activate expression of eNOS via a genomic receptor(s).
Export Options
About this article
Cite this article as:
Ruehlmann O. Dietrich and Mann E. Giovanni, Rapid Non-genomic Vasodilator Actions of Oestrogens and Sex Steroids, Current Medicinal Chemistry 2000; 7 (5) . https://dx.doi.org/10.2174/0929867003375038
DOI https://dx.doi.org/10.2174/0929867003375038 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
Call for Papers in Thematic Issues
Advances in Medicinal Chemistry: From Cancer to Chronic Diseases.
The broad spectrum of the issue will provide a comprehensive overview of emerging trends, novel therapeutic interventions, and translational insights that impact modern medicine. The primary focus will be diseases of global concern, including cancer, chronic pain, metabolic disorders, and autoimmune conditions, providing a broad overview of the advancements in ...read more
Approaches to the treatment of chronic inflammation
Chronic inflammation is a hallmark of numerous diseases, significantly impacting global health. Although chronic inflammation is a hot topic, not much has been written about approaches to its treatment. This thematic issue aims to showcase the latest advancements in chronic inflammation treatment and foster discussion on future directions in this ...read more
Cellular and Molecular Mechanisms of Non-Infectious Inflammatory Diseases: Focus on Clinical Implications
The Special Issue covers the results of the studies on cellular and molecular mechanisms of non-infectious inflammatory diseases, in particular, autoimmune rheumatic diseases, atherosclerotic cardiovascular disease and other age-related disorders such as type II diabetes, cancer, neurodegenerative disorders, etc. Review and research articles as well as methodology papers that summarize ...read more
Chalcogen-modified nucleic acid analogues
Chalcogen-modified nucleosides, nucleotides and oligonucleotides have been of great interest to scientific research for many years. The replacement of oxygen in the nucleobase, sugar or phosphate backbone by chalcogen atoms (sulfur, selenium, tellurium) gives these biomolecules unique properties resulting from their altered physical and chemical properties. The continuing interest in ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Plasticity of T Cell Differentiation and Cytokine Signature: A Double-Edged Sword for Immune Responses
Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry (Discontinued) Amino Acid Transporter-Targeted Radiotracers for Molecular Imaging in Oncology
Current Medicinal Chemistry On Electromagnetic Ablation of Biological Tissues: A Review
Recent Patents on Electrical Engineering Modulation of Tumour-Related Signaling Pathways by Natural Pentacyclic Triterpenoids and their Semisynthetic Derivatives
Current Medicinal Chemistry Mechanism of Action of Novel Glibenclamide Derivatives on Potassium and Calcium Channels for Insulin Secretion
Current Drug Targets Exploitation of the 3-Quinolinecarbonitrile Template for Src Tyrosine Kinase Inhibitors
Current Topics in Medicinal Chemistry Protein Kinase C Isozymes: Memory Therapeutic Potential
Current Drug Targets - CNS & Neurological Disorders Dietary Fat and Hypertension: A Novel Approach Through the Proteolytic Regulatory Enzymes of the Renin-Angiotensin-System
Cardiovascular & Hematological Agents in Medicinal Chemistry Biological Predictors of Aging and Potential of FTIR to Study Age-related Diseases and Aging Metabolic Fingerprint
Current Metabolomics Selection of Lung Cancer-Specific Landscape Phage for Targeted Drug Delivery
Combinatorial Chemistry & High Throughput Screening 4-Hydroxy-3-methoxyphenyl Substituted 3-methyl-tetrahydroquinoline Derivatives Obtained Through Imino Diels-Alder Reactions as Potential Antitumoral Agents
Letters in Drug Design & Discovery Systemic and Biophase Bioavailability and Pharmacokinetics of Nanoparticulate Drug Delivery Systems
Current Drug Delivery Pharmacogenetics Strategies: From Candidate Genes to Whole-Genome Association Analysis. Exploratory or Confirmatory Studies?
Current Pharmacogenomics and Personalized Medicine Molecular Imaging of Breast Cancer: Role of RGD Peptides
Mini-Reviews in Medicinal Chemistry High Mobility Group Box 1 Protein as a Potential Drug Target for Infection- and Injury-Elicited Inflammation
Inflammation & Allergy - Drug Targets (Discontinued) PET Imaging of Multidrug Resistance in Tumors Using 18F-Fluoropaclitaxel
Current Topics in Medicinal Chemistry Current Status of Thalidomide and CC-5013 in the Treatment of Metastatic Prostate Cancer
Anti-Cancer Agents in Medicinal Chemistry True Antisense Oligonucleotides with Modified Nucleotides Restricted in the Nconformation
Current Topics in Medicinal Chemistry Conference Report (3<sup>rd</sup> GTC Congress Report on Ubiquitin & Drug Discovery Feb 25-26, Palms Casino Resort, Las Vegas, NV, USA)
CNS & Neurological Disorders - Drug Targets Update on COX-2 Selective Inhibitors: Chemical Classification, Side Effects and their Use in Cancers and Neuronal Diseases
Current Topics in Medicinal Chemistry