Systemic Sarcoidosis with Thyroid Involvement

Hideyuki Okuma; Koshi Hashimoto; Xin Wang; Noriaki Ohkiba; Nozomi Murooka; Norikazu Akizuki; Takeshi Inazawa; Yoshihiro Ogawa

doi:10.2169/internalmedicine.8324-16

CASE REPORTS

Systemic Sarcoidosis with Thyroid Involvement

Hideyuki Okuma, Koshi Hashimoto, Xin Wang, Noriaki Ohkiba, Nozomi Murooka, Norikazu Akizuki, Takeshi Inazawa, Yoshihiro Ogawa

Author information

Hideyuki Okuma
Department of Endocrinology and Metabolism, Kashiwa City Kashiwa Hospital, Japan
Department of Molecular Endocrinology and Metabolism, Tokyo Medical and Dental University, Japan
Koshi Hashimoto
Department of Molecular Endocrinology and Metabolism, Tokyo Medical and Dental University, Japan
Department of Preemptive Medicine and Metabolism, Tokyo Medical and Dental University, Japan
Xin Wang
Department of Endocrinology and Metabolism, Kashiwa City Kashiwa Hospital, Japan
Noriaki Ohkiba
Department of Endocrinology and Metabolism, Kashiwa City Kashiwa Hospital, Japan
Nozomi Murooka
Department of Endocrinology and Metabolism, Kashiwa City Kashiwa Hospital, Japan
Norikazu Akizuki
Department of Respiratory Medicine, Kashiwa City Kashiwa Hospital, Japan
Takeshi Inazawa
Department of Endocrinology and Metabolism, Kashiwa City Kashiwa Hospital, Japan
Yoshihiro Ogawa
Department of Molecular Endocrinology and Metabolism, Tokyo Medical and Dental University, Japan

Keywords: thyroid sarcoidosis, thyroid needle biopsy

JOURNAL OPEN ACCESS

2017 Volume 56 Issue 16 Pages 2181-2186

DOI https://doi.org/10.2169/internalmedicine.8324-16

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Abstract

A 66-year-old woman, who was diagnosed with iritis, visited our hospital due to general malaise. A blood analysis revealed hypercalcemia. Computed tomography revealed mediastinal and hilar lymph node hyperplasia. Moreover, ⁶⁷Gallium scintigraphy demonstrated strong accumulation in the lesions, suggesting sarcoidosis. A core needle biopsy (CNB) of the hypoechoic areas of the thyroid was performed because the patient refused to undergo a bronchoscopic examination. The scattering of slightly acidophilic epithelioid cell granulomas was observed in the pathological examination of the biopsy specimen. Based on this finding, the patient was diagnosed with sarcoidosis. Although sarcoidosis rarely involves the thyroid gland, in the present case, thyroid CNB was an alternative diagnostic method that allowed a pathological diagnosis to be obtained.

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