An Autopsy Case of Lepidic Pulmonary Metastasis from Cholangiocarcinoma

Yohsuke Nagayoshi; Kazuko Yamamoto; Satoru Hashimoto; Keiko Hisatomi; Seiji Doi; Seiji Nagashima; Hirokazu Kurohama; Masahiro Ito; Takahiro Takazono; Shigeki Nakamura; Taiga Miyazaki; Shigeru Kohno

doi:10.2169/internalmedicine.55.5972

CASE REPORTS

An Autopsy Case of Lepidic Pulmonary Metastasis from Cholangiocarcinoma

Yohsuke Nagayoshi, Kazuko Yamamoto, Satoru Hashimoto, Keiko Hisatomi, Seiji Doi, Seiji Nagashima, Hirokazu Kurohama, Masahiro Ito, Takahiro Takazono, Shigeki Nakamura, Taiga Miyazaki, Shigeru Kohno

Author information

Yohsuke Nagayoshi
Department of Respiratory Medicine, National Hospital Organization Nagasaki Medical Center, Japan
Department of Molecular Microbiology and Immunology, Nagasaki University Graduate School of Biomedical Sciences, Japan
Kazuko Yamamoto
Department of Respiratory Medicine, National Hospital Organization Nagasaki Medical Center, Japan
Department of Molecular Microbiology and Immunology, Nagasaki University Graduate School of Biomedical Sciences, Japan
Satoru Hashimoto
Department of Respiratory Medicine, National Hospital Organization Nagasaki Medical Center, Japan
Keiko Hisatomi
Department of Respiratory Medicine, National Hospital Organization Nagasaki Medical Center, Japan
Seiji Doi
Department of Respiratory Medicine, National Hospital Organization Nagasaki Medical Center, Japan
Seiji Nagashima
Department of Respiratory Medicine, National Hospital Organization Nagasaki Medical Center, Japan
Hirokazu Kurohama
Department of Pathology, National Hospital Organization Nagasaki Medical Center, Japan
Masahiro Ito
Department of Pathology, National Hospital Organization Nagasaki Medical Center, Japan
Takahiro Takazono
Department of Molecular Microbiology and Immunology, Nagasaki University Graduate School of Biomedical Sciences, Japan
Shigeki Nakamura
Department of Molecular Microbiology and Immunology, Nagasaki University Graduate School of Biomedical Sciences, Japan
Taiga Miyazaki
Department of Molecular Microbiology and Immunology, Nagasaki University Graduate School of Biomedical Sciences, Japan
Shigeru Kohno
Department of Molecular Microbiology and Immunology, Nagasaki University Graduate School of Biomedical Sciences, Japan

Keywords: lepidic growth, lung metastasis, cholangiocarcinoma

JOURNAL OPEN ACCESS

2016 Volume 55 Issue 19 Pages 2849-2853

DOI https://doi.org/10.2169/internalmedicine.55.5972

Details

Abstract

We herein report the first case of pulmonary metastasis with lepidic growth that originated from cholangiocarcinoma. A 77-year-old man was admitted to our hospital due to exertional dyspnea and liver dysfunction. Computed tomography showed widespread infiltration and a ground-glass opacity in the lung and dilation of the intrahepatic bile duct. The pulmonary lesion progressed rapidly, and the patient died of respiratory failure. Cholangiocarcinoma and lepidic pulmonary metastasis were pathologically diagnosed by an autopsy. Lepidic pulmonary growth is an atypical pattern of metastasis, and immunopathological staining is useful to distinguish pulmonary metastasis from extrapulmonary cancer and primary pulmonary adenocarcinoma.

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