Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
ISSN-L : 0918-2918
CASE REPORTS
Immunohistochemical Findings of an Autopsied Lung Specimen from a Patient with Pandemic Influenza (A/H1N1pdm) Virus Infection
Jiro FujitaHajime HigaMasato AzumaMeika KinKoichiro KakazuMasahiko ToumeIwao NakazatoHaley L CashFutoshi HigaMasao TateyamaYutaka TsutsumiYuji Ohtsuki
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JOURNAL OPEN ACCESS

2012 Volume 51 Issue 5 Pages 507-512

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Abstract

A 24-year-old female presented with fever and dry cough. Influenza A virus infection was suspected and the patient was treated with neuraminidase inhibitors. Five days after diagnosis, the patient developed persistent fever and dyspnea, and was diagnosed with severe pneumonia. Despite intensive treatment, the pneumonia worsened and the patient died 14 days after admission. At autopsy, a diffuse alveolar damage (DAD) pattern was observed. Immunohistochemical evaluation indicated severe epithelial damage, resulting in successive regeneration of alveolar type II cells followed by marked proliferation of smooth muscle cells and an increase of collagen fibers at the tip of alveolar orifices.

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© 2012 by The Japanese Society of Internal Medicine
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