Captopril, an Angiotensin-Converting Enzyme Inhibitor, Induced Pulmonary Infiltration with Eosinophilia

Kouki WATANABE; Kazutaka NISHIMURA; Masahiro SHIODE; Michihito SEKIYA; Shuntarou IKEDA; Yoshikazu INOUE; Chiaki IWANAGA

doi:10.2169/internalmedicine.35.142

Kouki WATANABE, Kazutaka NISHIMURA, Masahiro SHIODE, Michihito SEKIYA, Shuntarou IKEDA, Yoshikazu INOUE, Chiaki IWANAGA

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Keywords: lymphocyte stimulation test, skin patch test, bronchoalveolar lavage, transbronchial lung biopsy

JOURNAL FREE ACCESS

1996 Volume 35 Issue 2 Pages 142-145

DOI https://doi.org/10.2169/internalmedicine.35.142

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Abstract

In this study, we investigated the association between the drug-induced pulmonary infiltration with eosinophilia (PIE) syndrome in a patient with hypertension and the angiotensin-converting enzyme inhibitor (ACE-I) captopril. Although the patient developed diffuse lung field infiltrates accompanied by productive cough and striking peripheral eosinophilia, these symptoms disappeared after termination of the administration of captopril, pronase and cephalexine. Furthermore, the results of the peripheral lymphocyte stimulation test, skin patch test and provocation test under informed consent showed a positive reaction only for captopril. Therefore, this patient was diagnosed as captopril-induced PIE syndrome.
(Internal Medicine 35: 142-145, 1996)

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