Thalamic Hyperperfusion in Verbal Hallucination of Parkinsonian Patients

Hideaki Matsui; Kazuto Nishinaka; Takafumi Miyoshi; Narihiro Hara; Masaya Oda; Tamotsu Kubori; Fukashi Udaka

doi:10.2169/internalmedicine.46.0191

ORIGINAL ARTICLES

Thalamic Hyperperfusion in Verbal Hallucination of Parkinsonian Patients

Hideaki Matsui, Kazuto Nishinaka, Takafumi Miyoshi, Narihiro Hara, Masaya Oda, Tamotsu Kubori, Fukashi Udaka

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Keywords: Parkinson's disease, verbal hallucination, three-dimensional stereotactic surface projection (3D-SSP), single photon emission computed tomography (SPECT)

JOURNAL OPEN ACCESS

2007 Volume 46 Issue 21 Pages 1765-1769

DOI https://doi.org/10.2169/internalmedicine.46.0191

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Abstract

Objective We compared brain perfusion image using 3D-SSP analysis of ¹²³I-IMP SPECT between Parkinson's disease patients with auditory verbal hallucination and those without auditory hallucination.
Methods Eighty-three cases with Parkinson's disease were studied. In 6 of these patients, auditory hallucination was noted. Among them, four cases had verbal hallucination and two other cases had elementary hallucination. Auditory hallucination was not found in the other 77 cases.
Results Right thalamic perfusion was significantly increased in the verbal hallucination group compared to the group that lacked auditory hallucination.
Conclusion In Parkinson's disease, the right thalamic hyperactive state may be related to verbal hallucination.

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