Pneumonitis Induced by Ou-gon (Scullcap)

Kei TAKESHITA; Yoshifumi SAISHO; Kumi KITAMURA; Noriko KABURAGI; Tomohiro FUNABIKI; Toshiyuki INAMURA; Yoshitaka OYAMADA; Koichiro ASANO; Kazuhiro YAMAGUCHI

doi:10.2169/internalmedicine.40.764

Kei TAKESHITA, Yoshifumi SAISHO, Kumi KITAMURA, Noriko KABURAGI, Tomohiro FUNABIKI, Toshiyuki INAMURA, Yoshitaka OYAMADA, Koichiro ASANO, Kazuhiro YAMAGUCHI

Author information

Kei TAKESHITA
the Department of Medicine, Keio University School of Medicine
Yoshifumi SAISHO
the Department of Medicine, Keio University School of Medicine
Kumi KITAMURA
the Department of Medicine, Keio University School of Medicine
Noriko KABURAGI
the Department of Medicine, Keio University School of Medicine
Tomohiro FUNABIKI
the Department of Medicine, Keio University School of Medicine
Toshiyuki INAMURA
the Department of Medicine, Keio University School of Medicine
Yoshitaka OYAMADA
the Department of Medicine, Keio University School of Medicine
Koichiro ASANO
the Department of Medicine, Keio University School of Medicine
Kazuhiro YAMAGUCHI
the Department of Medicine, Keio University School of Medicine

Keywords: herb medicine, drug-induced pneumonitis

JOURNAL FREE ACCESS

2001 Volume 40 Issue 8 Pages 764-768

DOI https://doi.org/10.2169/internalmedicine.40.764

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Abstract

A 53-year-old Japanese man with recurrent interstitial pneumonia was referred to us. The patient had taken a traditional herb medicine, otsu-ji-to, before the onset of pneumonia. A provocation test for each herbal ingredient contained in otsu-ji-to revealed that the pneumonitis had been induced by ou-gon (scullcap). Lymphocytosis with the CD8+ T-cell subset predominance was found in the bronchoalveolar lavage fluid and lymphocytic alveolitis was noted in the transbronchial lung biopsy specimen after the provocation test. Ou-gon, or scullcap, should be included in the list of drugs with definite causal association with pneumonitis.
(Internal Medicine 40: 764-768, 2001)

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